{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T18:51:43Z","timestamp":1792349503982,"version":"4.4.0"},"reference-count":10,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Whether younger age independently predicts biochemical recurrence (BCR) after radical prostatectomy (RP) remains controversial because previous studies have included heterogeneous pathological stages and treatment populations. We aimed to determine whether age independently predicts BCR following RP in patients with organ\u2010confined, node\u2010negative, margin\u2010negative (pT2N0R0) prostate cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed a retrospective multicenter cohort study of 4223 patients with pT2N0R0 prostate cancer treated with RP. Patients were stratified into \u2264\u200955 years (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009875; including 223 aged &lt;\u200950 years) and &gt;\u200955 years (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093348). BCR was defined as a confirmed prostate\u2010specific antigen level \u2265\u20090.2\u2009ng\/mL. Kaplan\u2013Meier analyses, multivariable Cox regression, restricted cubic spline modeling, subgroup analyses, and sensitivity analyses were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Younger patients had lower PSA levels, lower Grade Group, and lower crude BCR rates than older patients (3.8% vs. 5.9%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018). However, younger age was not independently associated with BCR after adjustment for clinicopathological variables (hazard ratio 0.52, 95% confidence interval 0.26\u20131.04;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.075). Higher PSA and Grade Group 3\u20135 independently predicted recurrence (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Age analyzed continuously, alternative age thresholds, restricted cubic spline modeling, and subgroup analyses consistently demonstrated no significant association between age and BCR. Limitations include the retrospective design, relatively short follow\u2010up, and use of BCR as a surrogate endpoint.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among men with pT2N0R0 prostate cancer treated with RP, age was not a statistically significant independent predictor of BCR, although a clinically meaningful effect cannot be excluded. Postoperative risk stratification should rely on established pathological factors rather than age alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70268","type":"journal-article","created":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T18:35:59Z","timestamp":1792348559000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Age Does Not Independently Predict Biochemical Recurrence in Prostate Cancer Following Radical Prostatectomy: A Comparative Analysis of 4223 pT2N0R0 Patients"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9380-8492","authenticated-orcid":false,"given":"Mehdi","family":"Kardoust Parizi","sequence":"first","affiliation":[{"name":"Department of Urology, Austrian Comprehensive Cancer Center Medical University of Vienna Vienna Austria"},{"name":"Department of Urology, Shariati Hospital Tehran University of Medical Sciences Tehran Iran"},{"name":"Uro\u2010Oncology Research Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre I.","family":"Karakiewicz","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montreal Health Center Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2911-7627","authenticated-orcid":false,"given":"Piotr","family":"Chlosta","sequence":"additional","affiliation":[{"name":"Department of Urology Jagiellonian University Medical College Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Nyir\u00e1dy","sequence":"additional","affiliation":[{"name":"Department of Urology Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Fazekas","sequence":"additional","affiliation":[{"name":"Department of Urology Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4073-6584","authenticated-orcid":false,"given":"Pawel","family":"Rajwa","sequence":"additional","affiliation":[{"name":"Department of Urology, Austrian Comprehensive Cancer Center Medical University of Vienna Vienna Austria"},{"name":"Second Department of Urology Centre of Postgraduate Medical Education Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6627-6179","authenticated-orcid":false,"given":"Shahrokh F.","family":"Shariat","sequence":"additional","affiliation":[{"name":"Department of Urology, Austrian Comprehensive Cancer Center Medical University of Vienna Vienna Austria"},{"name":"Department of Urology Weill Cornell Medicine New York New York USA"},{"name":"Department of Urology University of Texas Southwestern Dallas Texas USA"},{"name":"College of Medical Health Technologies Al\u2010Turath University Baghdad Iraq"},{"name":"Hourani Center for Applied Scientific Research Al\u2010Ahliyya Amman University Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,18]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"229","article-title":"Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"74","author":"Bray F.","year":"2024","journal-title":"CA: A Cancer Journal for Clinicians"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.eururo.2024.03.027","article-title":"EAU\u2010EANM\u2010ESTRO\u2010ESUR\u2010ISUP\u2010SIOG Guidelines on Prostate Cancer\u20142024 Update. Part I: Screening, Diagnosis, and Local Treatment With Curative Intent","volume":"86","author":"Cornford P.","year":"2024","journal-title":"European Urology"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.euf.2019.06.004","article-title":"Biochemical Recurrence in Prostate Cancer: The European Association of Urology Prostate Cancer Guidelines Panel Recommendations","volume":"6","author":"Van den Broeck T.","year":"2020","journal-title":"European Urology Focus"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.eururo.2024.04.010","article-title":"EAU\u2010EANM\u2010ESTRO\u2010ESUR\u2010ISUP\u2010SIOG Guidelines on Prostate Cancer. Part II\u20142024 Update: Treatment of Relapsing and Metastatic Prostate Cancer","volume":"86","author":"Tilki D.","year":"2024","journal-title":"European Urology"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1056\/NEJMoa1603144","article-title":"Inherited DNA\u2010Repair Gene Mutations in Men With Metastatic Prostate Cancer","volume":"375","author":"Pritchard C. C.","year":"2016","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nrurol.2014.91","article-title":"Prostate Cancer in Young Men: An Important Clinical Entity","volume":"11","author":"Salinas C. A.","year":"2014","journal-title":"Nature Reviews Urology"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/j.juro.2007.07.016","article-title":"Impact of Patient Age on Biochemical Recurrence Rates Following Radical Prostatectomy","volume":"178","author":"Magheli A.","year":"2007","journal-title":"Journal of Urology"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1093\/jjco\/hyt017","article-title":"Impact of Advanced Age on Biochemical Recurrence After Radical Prostatectomy in Japanese Men According to Pathological Stage","volume":"43","author":"Masuda H.","year":"2013","journal-title":"Japanese Journal of Clinical Oncology"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0090-4295(99)00168-5","article-title":"Age as a Prognostic Factor for Disease Recurrence After Radical Prostatectomy","volume":"54","author":"\u00d6bek C.","year":"1999","journal-title":"Urology"},{"key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/pros.24087","article-title":"Early\u2010Onset Prostate Cancer is Associated With Increased Risks of Disease Progression and Cancer\u2010Specific Mortality","volume":"81","author":"Shih H.\u2010J.","year":"2021","journal-title":"Prostate"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.70268","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pros.70268","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.70268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T18:36:01Z","timestamp":1792348561000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.70268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,18]]},"references-count":10,"alternative-id":["10.1002\/pros.70268"],"URL":"https:\/\/doi.org\/10.1002\/pros.70268","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,18]]},"assertion":[{"value":"2026-08-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"pros.70268"}}