{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:06:46Z","timestamp":1767960406502,"version":"3.49.0"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,7,6]],"date-time":"2004-07-06T00:00:00Z","timestamp":1089072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Proteins"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Amyloid fibrils, a key pathological feature of Alzheimer's disease (AD) and other amyloidosis implicated in neurodegeneration, have a characteristic cross\u2010\u03b2 structure. Here we present a structural model for the core of amyloid fibrils formed by the A\u03b2 peptide using computational approaches and experimental data. A\u03b2(15\u201336) was threaded against the parallel \u03b2\u2010helical proteins. Our multi\u2010layer model was constructed using the top scoring template 1lxa, a left\u2010handed parallel \u03b2\u2010helical protein. This six\u2010rung helical model has in\u2010register repeats of the A\u03b2(15\u201336) sequence. Each rung has three \u03b2\u2010strands separated by two turns. The model was tested using molecular dynamics simulations in explicit water, and is in good agreement with a number of experimental observations. In addition, a model based on right\u2010handed helical proteins is also described. The core structural model described here might serve as the building block of the A\u03b2(1\u201340) amyloid fibril as well as some other amyloid fibrils. Proteins 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/prot.20222","type":"journal-article","created":{"date-parts":[[2004,7,6]],"date-time":"2004-07-06T23:01:53Z","timestamp":1089154913000},"page":"357-364","source":"Crossref","is-referenced-by-count":54,"title":["Molecular modeling of the core of A\u03b2 amyloid fibrils"],"prefix":"10.1002","volume":"57","author":[{"given":"Jun\u2010tao","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Wetzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,7,6]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.61.070192.004503"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80115-4"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198006053022305"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.3650"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3233(08)60320-4"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.250288897"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1110\/ps.0225703"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi010805z"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.262663499"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205659200"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(99)77442-4"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.18.12619"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/11.9.761"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja0273290"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi971016d"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja000645z"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2003.11.008"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00003a003"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)00670-8"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0134(20000815)40:3<343::AID-PROT10>3.0.CO;2-S"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/gzg081"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1093-3263(00)00138-8"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80134-2"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5275.595"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1993.1626"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889892009944"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s008940100045"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.464397"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-015-7658-1_21"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/bip.360221211"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(00)89080-5"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0134(20010101)42:1<38::AID-PROT50>3.0.CO;2-3"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(02)00809-2"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.052703499"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsb1195-990"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi000637v"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.23.13407"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1999.3218"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.212206899"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6107(01)00013-X"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.042681399"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.142459399"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.26.18589"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.052706099"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00069a001"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5300.630"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1997.1348"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(98)77812-9"}],"container-title":["Proteins: Structure, Function, and Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fprot.20222","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prot.20222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T17:28:37Z","timestamp":1697218117000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/prot.20222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7,6]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1002\/prot.20222"],"URL":"https:\/\/doi.org\/10.1002\/prot.20222","archive":["Portico"],"relation":{},"ISSN":["0887-3585","1097-0134"],"issn-type":[{"value":"0887-3585","type":"print"},{"value":"1097-0134","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7,6]]}}}