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By extensive all\u2010atom Monte Carlo simulations, we find that a variety of \u03b2\u2010sheet structures with distinct turns are readily accessible for full\u2010length A\u03b242. In the simulations, wild type (WT) A\u03b242 preferentially populates two major classes of conformations, either extended with high \u03b2\u2010sheet content or more compact with lower \u03b2\u2010sheet content. The three mutations studied alter the balance between these classes. Strong mutational effects are observed in a region centered at residues 23\u201326, where WT A\u03b242 tends to form a turn. The aggregation\u2010accelerating E22G mutation associated with early onset of Alzheimer's disease makes this turn region conformationally more diverse, whereas the aggregation\u2010decelerating F20E mutation has the reverse effect, and the E22G\/I31E mutation reduces the turn population. Comparing results for the four A\u03b242 variants, we identify specific conformational properties of residues 23\u201326 that might play a key role in aggregation. 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