{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:41:56Z","timestamp":1791067316715,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["GM080642"],"award-info":[{"award-number":["GM080642"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Proteins"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Members of the cyanovirin\u2010N homolog (CVNH) lectin family are found in bacteria, fungi and plants. As part of our ongoing work on CVNH structure\u2010function studies, we determined the high\u2010resolution NMR solution structure of the homolog from the wheat head blight disease causing ascomycetous fungus <jats:italic>Gibberella zeae<\/jats:italic> (or <jats:italic>Fusarium graminearum<\/jats:italic>), hereafter called GzCVNH. Like cyanovirin\u2010N (CV\u2010N), GzCVNH comprises two tandem sequence repeats and the protein sequence exhibits 30% identity with CV\u2010N. The overall structure is similar to those of other members of the CVNH family, with the conserved pseudo\u2010symmetric halves of the structure, domains A and B, closely resembling recently determined structures of <jats:italic>Tuber borchii<\/jats:italic>, <jats:italic>Neurospora crassa,<\/jats:italic> and <jats:italic>Ceratopteris richardii<\/jats:italic> CVNH proteins. Although GzCVNH exhibits a similar glycan recognition profile to CV\u2010N and specifically binds to Man\u03b1(1\u20102)Man\u03b1, its weak carbohydrate binding affinity to only one binding site is insufficient for conferring anti\u2010HIV activity. Proteins 2011; \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/prot.22981","type":"journal-article","created":{"date-parts":[[2011,1,18]],"date-time":"2011-01-18T22:57:19Z","timestamp":1295391439000},"page":"1538-1549","source":"Crossref","is-referenced-by-count":17,"title":["NMR solution structure of a cyanovirin homolog from wheat head blight fungus"],"prefix":"10.1002","volume":"79","author":[{"given":"Elena","family":"Matei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Louis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JunGoo","family":"Jee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela 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