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Here the solution structure of the forkhead DNA binding domain of <jats:italic>Brugia malayi<\/jats:italic> DAF\u201016a, a putative ortholog of <jats:italic>Caenorhabditis elegans<\/jats:italic> DAF\u201016, is reported. It is believed to be the first structure of a forkhead or winged helix domain from an invertebrate. <jats:italic>C. elegans<\/jats:italic> DAF\u201016 is involved in the insulin\/IGF\u2010I signaling pathway and helps control metabolism, longevity, and development. Conservation of sequence and structure with human FOXO proteins suggests that <jats:italic>B. malayi<\/jats:italic> DAF\u201016a is a member of the FOXO family of forkhead proteins. Proteins 2014; 82:3490\u20133496. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/prot.24701","type":"journal-article","created":{"date-parts":[[2014,10,9]],"date-time":"2014-10-09T08:55:56Z","timestamp":1412844956000},"page":"3490-3496","source":"Crossref","is-referenced-by-count":4,"title":["The solution structure of the forkhead box\u2010<scp>O<\/scp><scp>DNA<\/scp> binding domain of <scp><i>B<\/i><\/scp><i>rugia malayi<\/i><scp>DAF<\/scp>\u201016a"],"prefix":"10.1002","volume":"82","author":[{"given":"Sarah K.","family":"Casper","sequence":"first","affiliation":[{"name":"Department of Biological Sciences University of Wisconsin\u2010Whitewater Whitewater Wisconsin 53190"},{"name":"Department of Health Sciences Blackhawk Technical College Janesville Wisconsin 53545"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott J.","family":"Schoeller","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of 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