{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:43:28Z","timestamp":1788871408764,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,28]],"date-time":"2015-02-28T00:00:00Z","timestamp":1425081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"crossref","award":["FT100100690"],"award-info":[{"award-number":["FT100100690"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Health and Medical Research Council; Grant number:","award":["1063786"],"award-info":[{"award-number":["1063786"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Proteins"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    New anti\u2010malarial treatments are desperately required to face the spread of drug resistant parasites. Inhibition of metalloaminopeptidases,\n                    <jats:italic>Pf<\/jats:italic>\n                    A\u2010M1 and\n                    <jats:italic>Pf<\/jats:italic>\n                    A\u2010M17, is a validated therapeutic strategy for treatment of\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    malaria. Here, we describe the crystal structures of\n                    <jats:italic>Pf<\/jats:italic>\n                    A\u2010M1 and\n                    <jats:italic>Pf<\/jats:italic>\n                    A\u2010M17 bound to chemotherapeutic agent Tosedostat. The inhibitor occupies the enzymes' putative product egress channels in addition to the substrate binding pockets; however, adopts different binding poses when bound to\n                    <jats:italic>Pf<\/jats:italic>\n                    A\u2010M1 and\n                    <jats:italic>Pf<\/jats:italic>\n                    A\u2010M17. These findings will be valuable for the continued development of selective inhibitors of\n                    <jats:italic>Pf<\/jats:italic>\n                    A\u2010M1 and\n                    <jats:italic>Pf<\/jats:italic>\n                    A\u2010M17. Proteins 2015; 83:789\u2013795. \u00a9 2015 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/prot.24771","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T16:59:01Z","timestamp":1422896341000},"page":"789-795","source":"Crossref","is-referenced-by-count":17,"title":["X\u2010ray crystal structures of an orally available aminopeptidase inhibitor,\n                    <scp>T<\/scp>\n                    osedostat, bound to anti\u2010malarial drug targets\n                    <scp>\n                      <i>P<\/i>\n                    <\/scp>\n                    <i>f<\/i>\n                    <scp>A<\/scp>\n                    \u2010\n                    <scp>M<\/scp>\n                    1 and\n                    <scp>\n                      <i>P<\/i>\n                    <\/scp>\n                    <i>f<\/i>\n                    <scp>A<\/scp>\n                    \u2010\n                    <scp>M<\/scp>\n                    17"],"prefix":"10.1002","volume":"83","author":[{"given":"Nyssa","family":"Drinkwater","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Monash University Melbourne Victoria 3800 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca S.","family":"Bamert","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Monash University Melbourne Victoria 3800 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komagal Kannan","family":"Sivaraman","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Monash University Melbourne Victoria 3800 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Paiardini","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biochimiche \u201cA. Rossi Fanelli\u201d Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheena","family":"McGowan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Monash University Melbourne Victoria 3800 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,28]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","volume-title":"WHO Global Malaria Programme World Malaria Report. Geneva, Switzerland: World Health Organization; 2013","author":"WHO","year":"2013"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","unstructured":"CheesemanIH MillerBA NairS NkhomaS TanA TanJC Al SaaiS PhyoAP MooCL LwinKM McGreadyR AshleyE ImwongM StepniewskaK YiP DondorpAM MayxayM NewtonPN WhiteNJ NostenF FerdigMT AndersonTJC.A major genome region underlying artemisinin resistance in malaria.Science2012;336:79\u201382. [PMC][10.1126\/science.1215966] [22491853][Mismatch]","DOI":"10.1126\/science.1215966"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-8-10"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2010.04.026"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1105601108"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M609251200"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0807398106"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2009.08.004"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2013.07.015"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm070733v"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm501323a"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2014.864276"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.06245-11"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911813107"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm4005972"},{"key":"e_1_2_6_17_1","doi-asserted-by":"crossref","unstructured":"LeslieAGW. The integration of macromolecular diffraction data. Acta Crystallographica Section D\u2010Biological Crystallography2006;62:48\u201357.","DOI":"10.1107\/S0907444905039107"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444910045749"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889807021206"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444912001308"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444904019158"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm101227t"}],"container-title":["Proteins: Structure, Function, and Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fprot.24771","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fprot.24771","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prot.24771","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T10:18:28Z","timestamp":1696501108000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/prot.24771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,28]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1002\/prot.24771"],"URL":"https:\/\/doi.org\/10.1002\/prot.24771","archive":["Portico"],"relation":{},"ISSN":["0887-3585","1097-0134"],"issn-type":[{"value":"0887-3585","type":"print"},{"value":"1097-0134","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,28]]}}}