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The crystal structure of<jats:italic>Bp<\/jats:italic>HldC belongs to the nucleotidyltransferase \u03b1\/\u03b2 phosphodiesterase superfamily sharing a common Rossmann\u2010like \u03b1\/\u03b2 fold with a conserved T\/HXGH sequence motif. The invariant catalytic key residues of<jats:italic>Bp<\/jats:italic>HldC indicate that the core catalytic mechanism of<jats:italic>Bp<\/jats:italic>HldC may be similar to that of other closest homologues. Intriguingly, a reorientation of the C\u2010terminal helix seems to guide open and close states of the active site for the catalytic reaction.<\/jats:p>","DOI":"10.1002\/prot.25398","type":"journal-article","created":{"date-parts":[[2017,10,7]],"date-time":"2017-10-07T06:32:39Z","timestamp":1507357959000},"page":"124-131","source":"Crossref","is-referenced-by-count":9,"title":["Crystal structure of D\u2010<i>glycero<\/i>\u2010<i>\u0392<\/i>\u2010D\u2010<i>manno<\/i>\u2010heptose\u20101\u2010phosphate adenylyltransferase from<i>Burkholderia pseudomallei<\/i>"],"prefix":"10.1002","volume":"86","author":[{"given":"Jimin","family":"Park","sequence":"first","affiliation":[{"name":"College of Pharmacy Ewha W. University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyojin","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy Ewha W. University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suwon","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy Ewha W. University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daeun","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy Ewha W. University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi\u2010Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy Ewha W. University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2205-1453","authenticated-orcid":false,"given":"Dong Hae","family":"Shin","sequence":"additional","affiliation":[{"name":"College of Pharmacy Ewha W. 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