{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:13:55Z","timestamp":1772118835386,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["15\u201054\u201012363"],"award-info":[{"award-number":["15\u201054\u201012363"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["19\u201054\u201012015"],"award-info":[{"award-number":["19\u201054\u201012015"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteins"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Old world scorpions produce an abundance of toxins called \u03b1\u2010NaTx, which interfere with the fast inactivation of voltage\u2010gated sodium channels. Their selectivity to channels of mammals or insects depends on a part of toxin named the specificity module. We report here the spatial structure of a major and broadly active toxin MeuNaTx\u03b1\u20101 from the venom of\n                    <jats:italic>Mesobuthus eupeus<\/jats:italic>\n                    . Notably, its specificity module is markedly different from other \u03b1\u2010NaTx with known 3D structure. Close inspection shows that its conformation is a result of an interplay between protein motifs such as the nest and niche, which eventually shape \u03b1\u2010NaTx structural diversity.\n                  <\/jats:p>","DOI":"10.1002\/prot.26074","type":"journal-article","created":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T13:56:16Z","timestamp":1615643776000},"page":"1055-1060","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Structure of MeuNaTx\u03b1\u20101 toxin from scorpion venom highlights the importance of the nest motif"],"prefix":"10.1002","volume":"89","author":[{"given":"Konstantin S.","family":"Mineev","sequence":"first","affiliation":[{"name":"Shemyakin\u2010Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences  Moscow Russian Federation"},{"name":"Moscow Institute of Physics and Technology (State University)  Moscow Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexey I.","family":"Kuzmenkov","sequence":"additional","affiliation":[{"name":"Shemyakin\u2010Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences  Moscow Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander S.","family":"Arseniev","sequence":"additional","affiliation":[{"name":"Shemyakin\u2010Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences  Moscow Russian Federation"},{"name":"Moscow Institute of Physics and Technology (State University)  Moscow Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1359-0076","authenticated-orcid":false,"given":"Alexander A.","family":"Vassilevski","sequence":"additional","affiliation":[{"name":"Shemyakin\u2010Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences  Moscow Russian Federation"},{"name":"Moscow Institute of Physics and Technology (State University)  Moscow Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2006.09.023"},{"issue":"7","key":"e_1_2_8_3_1","first-page":"979","article-title":"Amino acid sequence of 2 neurotoxins from the scorpion Buthus eupeus venom","volume":"10","author":"Volkova TM","year":"1984","journal-title":"Bioorg Khim"},{"issue":"10","key":"e_1_2_8_4_1","first-page":"1306","article-title":"The structure of Buthus eupeus neurotoxin M9 in a solution studied by 1H\u2010NMR spectroscopy","volume":"12","author":"Pashkov VS","year":"1986","journal-title":"Bioorg 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