{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T21:14:55Z","timestamp":1791666895643,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011211","name":"State Key Laboratory of Genetic Engineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011211","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteins"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The two\u2010component regulatory system (TCS) is a major regulatory system in bacteria that occurs in response to environmental changes and involves the sensor histidine kinase (HK) protein and response regulator (RR) protein. Among the TCSs, PhoR\/PhoB is crucial for bacteria to adapt to changes in environmental phosphate concentrations. In addition, recent studies have shown that PhoR binding to the MgtC virulence factor activates phosphate transport for normal pathogenesis. In this work, we determined the crystal structure of the catalytic ATP binding domain of the PhoR sensor histidine kinase from\n                    <jats:italic>Vibrio cholera<\/jats:italic>\n                    , compared the structure with the known HK protein structures and discussed the potential binding interface with MgtC.\n                  <\/jats:p>","DOI":"10.1002\/prot.26473","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T23:24:09Z","timestamp":1675380249000},"page":"999-1004","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Crystal structure of the catalytic\n                    <scp>ATP<\/scp>\n                    \u2010binding domain of the\n                    <scp>PhoR<\/scp>\n                    sensor histidine kinase"],"prefix":"10.1002","volume":"91","author":[{"given":"Ruiliang","family":"Jia","sequence":"first","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Shanghai Key Laboratory of Bioactive Small Molecules, Department of Physiology and Neurobiology School of Life Sciences, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Shanghai Key Laboratory of Bioactive Small Molecules, Department of Physiology and Neurobiology School of Life Sciences, Fudan University  Shanghai China"},{"name":"Human Phenome Institute Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoyuki","family":"Hattori","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Shanghai Key Laboratory of Bioactive Small Molecules, Department of Physiology and Neurobiology School of Life Sciences, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2021.1949883"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.00130-22"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.00811-22"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.00121-22"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11318-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11101524"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00176-20"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00412-17"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00119-20"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.3.1112-1115.2003"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2020.126448"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.7b00612"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1493"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/ecosalplus.ESP-0006-2019"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2009.08.011"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1107\/S1744309109054220"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/23968"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi049474r"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600886"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2008.12.006"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.08.032"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001493"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001776"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4258"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02310-9"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14540-5"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1921307117"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M106080200"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1107\/S2059798318017795"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1107\/S2059798318004576"},{"issue":"2","key":"e_1_2_9_32_1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1107\/S0907444909047337","article-title":"XDS","volume":"66","author":"Xds KW","year":"2010","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889807021206"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03819-2"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-022-01488-1"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444910007493"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1107\/S2059798319011471"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444909042073"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac240"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku316"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac387"}],"container-title":["Proteins: Structure, Function, and Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prot.26473","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/prot.26473","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prot.26473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T09:34:41Z","timestamp":1692437681000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/prot.26473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,17]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1002\/prot.26473"],"URL":"https:\/\/doi.org\/10.1002\/prot.26473","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/PROT.26473\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/PROT.26473\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/PROT.26473\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/PROT.26473\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/PROT.26473\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/PROT.26473\/v2\/review2","asserted-by":"object"}]},"ISSN":["0887-3585","1097-0134"],"issn-type":[{"value":"0887-3585","type":"print"},{"value":"1097-0134","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,17]]},"assertion":[{"value":"2022-12-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}