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In this study, we identified novel fibrinogen cleavage sites targeted by\n                    <jats:italic>Der m 1<\/jats:italic>\n                    , which are distinct from those cleaved by thrombin or plasmin. By employing biochemical and bioinformatic approaches, we identified the fibrinogen \u03b1C domain as a key component of\n                    <jats:italic>Der m 1<\/jats:italic>\n                    \u2010derived fibrinogen cleavage products (FCPs). To assess their functional effects, we treated human bronchial epithelial cells with\n                    <jats:italic>Der m 1<\/jats:italic>\n                    \u2010derived FCPs and the fibrinogen \u03b1C domain. Both treatments significantly enhanced cell adhesion, with effects peaking at 2\u20134\u2009h post\u2010treatment before gradually declining. Transcriptomic analysis, including RNA sequencing and gene set enrichment analysis (GSEA), revealed that both\n                    <jats:italic>Der m 1<\/jats:italic>\n                    \u2010derived FCPs and the \u03b1C domain induced similar transcriptional responses, particularly in adhesion\u2010related pathways involving integrin signaling. Functional validation using Cilengitide, a cyclic RGD peptide that antagonizes \u03b1V\u03b2\n                    <jats:sub>3<\/jats:sub>\n                    and \u03b1V\u03b2\n                    <jats:sub>5<\/jats:sub>\n                    integrins, confirmed that the pro\u2010adhesive effects were integrin \u03b1V\u2010dependent. These findings reveal that\n                    <jats:italic>Der m 1<\/jats:italic>\n                    not only cleaves fibrinogen but also produces bioactive fragments that influence epithelial adhesion and signaling, offering new insight into airway remodeling in allergic asthma.\n                  <\/jats:p>","DOI":"10.1002\/prot.70051","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T14:55:55Z","timestamp":1760453755000},"page":"692-706","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fibrinogen\n                    <scp>\u03b1C<\/scp>\n                    \u2010Domain Derived From Group 1 Allergen of\n                    <i>Dermatophagoides microceras<\/i>\n                    Modulates Cell Adhesion in Human Bronchial Epithelial Cells"],"prefix":"10.1002","volume":"94","author":[{"given":"Chia\u2010Yang","family":"Lin","sequence":"first","affiliation":[{"name":"Institute of Medicine Chung Shan Medical University  Taichung Taiwan"},{"name":"Department of Family Medicine Chung Shan Medical University Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao\u2010Ruei","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Chung Shan Medical University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiunn\u2010Liang","family":"Ko","sequence":"additional","affiliation":[{"name":"Institute of Medicine Chung Shan Medical University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6784-9795","authenticated-orcid":false,"given":"Yu\u2010Fan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Chung Shan Medical University  Taichung Taiwan"},{"name":"Division of Allergy, Department of Pediatrics Chung Shan Medical University Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Statpearls","author":"Chabra R.","year":"2025"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2023.04.008"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40629\u2010022\u201000226\u20105"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/mve.12052"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016\u2010018\u20108693\u20100"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091\u20106749(91)90249\u2010n"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.8.4572"},{"issue":"3","key":"e_1_2_9_9_1","first-page":"127","article-title":"Distribution of Allergens in Children With Different Atopic Disorders in Central Taiwan","volume":"47","author":"Huang H. W.","year":"2006","journal-title":"Acta Paediatrica Taiwanica"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21168"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40413\u2010017\u20100154\u20103"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15678"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073810"},{"key":"e_1_2_9_14_1","unstructured":"T. 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