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This study systematically investigated effects of four statins (atorvastatin, pitavastatin, cerivastatin, and lovastatin) on neuronal cells under pathological condition using an in vitro model depicting ischemic injury, as well as tested under physiological condition. All four statins at micromolar concentrations display toxic effects on neuron cells under physiological condition. Atorvastatin and cerivastatin but not pitavastatin or lovastatin at nanomolar concentrations display protective effects on neuron cells under ischemic injury condition, via decreased ischemic injury\u2010induced oxidative stress, oxidative damage, and inflammation. Mechanistically, atorvastatin, pitavastatin, and lovastatin induces neuron cell apoptosis via prenylation\u2010independent manner. Other mechanisms are involved in the pro\u2010apoptotic effect of cerivastatin. Prenylation is not involved in the protective effects of statins under ischemic injury condition. Our work provides better understanding on the multiple differential effects of statins on neuron cells under physiological condition and ischemic injury, and elucidate their underlying mechanisms, which may be of relevance to the influence of statins in CNS.<\/jats:p>","DOI":"10.1002\/prp2.1001","type":"journal-article","created":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T10:06:27Z","timestamp":1661594787000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Biphasic effects of statins on neuron cell functions under oxygen\u2013glucose deprivation and normal culturing conditions via different mechanisms"],"prefix":"10.1002","volume":"10","author":[{"given":"Hui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology Hubei Provincial Hospital of Integrated Chinese and Western Medicine  Wuhan 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