{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T20:28:42Z","timestamp":1770755322685,"version":"3.50.0"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,11,20]],"date-time":"2022-11-20T00:00:00Z","timestamp":1668902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Opioid use and associated morbidity and mortality have increased in several countries during the past 20\u2009years. We performed a study whose objective was to assess the frequency and causes of opioid\u2010related emergency division (ED) visits in an adult tertiary Swiss University Hospital over 9\u2009weeks in 2018. We primarily assessed opioid\u2010related adverse drug reactions (ADR), secondary overdose, misuse, abuse, and insufficient pain relief. Current opioid use was identified in 1037 (8.3%) of the 12\u2009470 included ED visits. In 64 opioid users, an ADR was identified as a contributing cause of the ED visit, representing 6.2% of opioid users, and 0.5% of the total ED visits. Moreover, we identified an overdose in 16 opioid users, misuse or abuse in 19 opioid users, and compatible withdrawal symptoms in 7 opioid users. After pooling all these events, we conclude that the ED visits could be related to opioid use in 10.2% of opioid users. Finally, in 201 opioid users, insufficient pain relief (pain not responding to the current pharmacological treatment) was identified as a contributing cause of ED visits. In these cases, other factors than simply pharmacological nonresponse may have been involved. In the context of an ever\u2010increasing opioid use to better control chronic pain situations, these results should reinforce emergency network epidemiological surveillance studies at a national level.<\/jats:p>","DOI":"10.1002\/prp2.1033","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T06:59:17Z","timestamp":1669013957000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Opioid\u2010related adverse drug reactions in patients visiting the emergency division of a tertiary hospital"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8472-7714","authenticated-orcid":false,"given":"Kuntheavy","family":"Ing Lorenzini","sequence":"first","affiliation":[{"name":"Division of Clinical Pharmacology and Toxicology, Multidisciplinary Pain Center, Department of Anaesthesiology, Pharmacology, Intensive Care and Emergency Medicine University Hospitals of Geneva  Geneva Switzerland"},{"name":"Faculty of Medicine University of Geneva  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Wainstein","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology and Toxicology, Multidisciplinary Pain Center, Department of Anaesthesiology, Pharmacology, Intensive Care and Emergency Medicine University Hospitals of Geneva  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herv\u00e9","family":"Spechbach","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Geneva  Geneva Switzerland"},{"name":"Division of Primary Care, Department of Primary Care Medicine University Hospitals of Geneva  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Sarasin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Geneva  Geneva Switzerland"},{"name":"Division of Emergency Medicine, Department of Anaesthesiology, Pharmacology, Intensive Care and Emergency Medicine University Hospitals of Geneva  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majd","family":"Ramlawi","sequence":"additional","affiliation":[{"name":"Division of Emergency Medicine La Tour Medical Group  Meyrin Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jules","family":"Desmeules","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology and Toxicology, Multidisciplinary Pain Center, Department of Anaesthesiology, Pharmacology, Intensive Care and Emergency Medicine University Hospitals of Geneva  Geneva Switzerland"},{"name":"Faculty of Medicine University of Geneva  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Piguet","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology and Toxicology, Multidisciplinary Pain Center, Department of Anaesthesiology, Pharmacology, Intensive Care and Emergency Medicine University Hospitals of Geneva  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,20]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"IASP.Unrelieved pain is a major global healthcare problem.2013."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm056"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e3182a95d86"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1011512"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S244173"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-019-02686-2"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.8913"},{"key":"e_1_2_11_9_1","first-page":"234","article-title":"Why not an opioid epidemic in Europe like in the USA?","volume":"21","author":"Soriano V","year":"2019","journal-title":"AIDS Rev"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1337"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(19)30156-2"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1786"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(19)30128-8"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1291"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-017-2086-6"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-016-0755-x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000672"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11938-016-0112-0"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.05.020"},{"key":"e_1_2_11_20_1","first-page":"329","article-title":"Adverse drug reactions due to opioid use in oldest\u2010old patients visiting the emergency unit of the Geneva geriatric hospital","volume":"11","author":"Ing Lorenzini K","year":"2022","journal-title":"J Frailty Aging"},{"key":"e_1_2_11_21_1","unstructured":"Uppsala Monitoring Centre.The use of the WHO\u2010UMC system for standardised case causality assessment."},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.05.053"},{"key":"e_1_2_11_23_1","unstructured":"UpToDate.UpToDate Lexicomp\u00aedrug interactions."},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-038079"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.36076\/ppj\/2019.22.537"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.1464"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1736"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70251-0"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2019.06.011"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v5.i3.73"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw097"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-019-00660-0"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2011\/14\/145"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1017\/cem.2019.464"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/24740527.2019.1587290"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2149"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017739"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2019.03.052"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000643"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.2174\/187447370801150611184218"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2018.10.389"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1067\/mem.2001.119456"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12266"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2010.03015.x"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002461"}],"container-title":["Pharmacology Research &amp; Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prp2.1033","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/prp2.1033","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prp2.1033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T17:01:58Z","timestamp":1692550918000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/prp2.1033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,20]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1002\/prp2.1033"],"URL":"https:\/\/doi.org\/10.1002\/prp2.1033","archive":["Portico"],"relation":{},"ISSN":["2052-1707","2052-1707"],"issn-type":[{"value":"2052-1707","type":"print"},{"value":"2052-1707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,20]]},"assertion":[{"value":"2022-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01033"}}