{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T21:54:51Z","timestamp":1788990891336,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The current recommendation for therapeutic monitoring of vancomycin has recently suggested AUC\u2010guided dosing in patients with serious methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> infections. The study objective was to evaluate mathematical equations and trapezoidal methods for calculating the 24\u2009h area under the plasma vancomycin concentration\u2010time curve (AUC24). The analysis of plasma vancomycin concentrations was performed in 20 adult patients treated with intravenous vancomycin. For each patient, AUC24 was estimated using two methods including, equation and trapezoidal calculation. The AUC24 from two methods was analyzed for correlation. The correlation between the equation and trapezoidal methods was strong. The coefficient of determination (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>) values was greater than .99. The two plasma vancomycin concentrations to achieve the highest correlation were concentration at 2.5 to 3\u00a0h after starting the infusion and concentration at 1\u00a0h before the next dose. Moreover, the AUC24 calculation from trapezoidal and equation methods showed that 19 out of 20 patients (95%) had AUC24 of more than 400\u2009mg\u00b7h\/L, and more than 50% in this group had AUC24\/MIC greater than 600. Of those patients with AUC\u2010trapezoidal &gt;600, 15.38% of patients had trough under 15\u2009mg\/L, 15.38% of patients had trough in the range 15 to 20\u2009mg\/L and 69.23% of patients had trough more than 20\u2009mg\/L. The results of AUC\u2010equation were similar to those of the AUC\u2010trapezoidal method. Our study confirmed that the AUC monitoring is more appropriate than the trough vancomycin concentration. Given these considerations, the AUC\u2010equation method is better and more practical to use in part of a point\u2010of\u2010care treatment, especially in the part of the Bayesian program is not available. The best sampling time point of the peak concentration was 0.5\u20131\u00a0h after 2\u2010h infusion.<\/jats:p>","DOI":"10.1002\/prp2.1046","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T04:15:36Z","timestamp":1672632936000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of the mathematical equation and trapezoidal approach for 24\u2009h area under the plasma concentration\u2010time curve calculation in patients who received intravenous vancomycin in an acute care setting"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4564-7900","authenticated-orcid":false,"given":"Pimonrat","family":"Chanapiwat","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6193-6433","authenticated-orcid":false,"given":"Taniya","family":"Paiboonvong","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy Rangsit University  Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2964-6732","authenticated-orcid":false,"given":"Pinyo","family":"Rattanaumpawan","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6782-2939","authenticated-orcid":false,"given":"Preecha","family":"Montakantikul","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacy, Department of Pharmacy, Faculty of Pharmacy Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1]]},"reference":[{"key":"e_1_2_13_2_1","first-page":"587","volume-title":"Therapeutic Drug Monitoring","author":"Rodvold KA","year":"1995"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200443130-00005"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/zxaa036"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0897190016642692"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2014.05.016"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000359"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02042-17"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01293-17"},{"issue":"1","key":"e_1_2_13_10_1","doi-asserted-by":"crossref","first-page":"e0088621","DOI":"10.1128\/AAC.00886-21","article-title":"Acute kidney injury associated with area under the curve versus trough monitoring of vancomycin in obese patients","volume":"66","author":"D'Amico H","year":"2022","journal-title":"Antimicrob Agents Chemother"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02535-16"},{"issue":"1","key":"e_1_2_13_12_1","first-page":"e01684","article-title":"Identification of vancomycin exposure\u2010toxicity thresholds in hospitalized patients receiving intravenous vancomycin","volume":"62","author":"Zasowski EJ","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343162"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2018.08.024"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2234"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz051"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9100672"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-05858-6"},{"issue":"8","key":"e_1_2_13_19_1","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1017\/ice.2021.296","article-title":"Effectiveness of a vancomycin dosing protocol guided by area under the concentration\u2010time curve to minimal inhibitory concentration (AUC\/MIC) with multidisciplinary team support to improve hospital\u2010wide adherence to a vancomycin dosing protocol: a pilot study","volume":"43","author":"Katawethiwong P","year":"2022","journal-title":"Infect Control Hosp Epidemiol"}],"container-title":["Pharmacology Research &amp; 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