{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T16:37:58Z","timestamp":1774543078794,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["950133"],"award-info":[{"award-number":["950133"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We aimed to determine the effects of isoproterenol on arrhythmia recurrence in atrioventricular nodal re\u2010entrant tachycardia (AVNRT) patients treated with catheter ablation. The present randomized controlled clinical trial was conducted on AVNRT patients candidates for radiofrequency ablation (RFA). The patients were randomly assigned to receive isoproterenol (0.5\u20134\u00a0\u03bcg\/min) or not (control group) for arrhythmia re\u2010induction after ablation. The results of the electrophysiological (EP) study, the ablation parameters, and the arrhythmia recurrence rate were recorded. We evaluated 206 patients (53 males and 153 females) with a mean (SD) age of 49.87 (15.5)\u00a0years in two groups of isoproterenol (<jats:italic>n<\/jats:italic>\u00a0=\u00a0103) and control (<jats:italic>n<\/jats:italic>\u00a0=\u00a0103). No statistically significant difference was observed between the two studied groups in age, gender, EP study, and ablation parameters. The success rate of ablation was 100% in both groups. During ~16.5\u00a0months of follow\u2010up, one patient (1%) in the isoproterenol group and four patients (3.8%) in the control group experienced AVNRT recurrence (HR\u00a0=\u00a00.245; 95% confidence interval [CI], 0.043\u20131.418; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.173). Based on the Kaplan\u2013Meier analysis, there was no significant difference in the incidence rate of arrhythmia recurrence during the follow\u2010up period between the two studied groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.129). Additionally, there were no significant differences between the arrhythmia's recurrence according to age, gender, junctional rhythm, type of AVNRT arrhythmia, and DAVN persistence after ablation. Although isoproterenol administration for arrhythmia re\u2010induction after ablation did not alleviate the treatment outcomes and arrhythmia recurrence following RFA in AVNRT patients, further studies with a larger sample size and a longer duration of follow\u2010up are necessary.<\/jats:p>","DOI":"10.1002\/prp2.1068","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T07:17:40Z","timestamp":1677655060000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of the effects of isoproterenol on arrhythmia recurrence following catheter ablation in patients with atrioventricular nodal re\u2010entrant tachycardia: A randomized controlled clinical trial"],"prefix":"10.1002","volume":"11","author":[{"given":"Neda","family":"Vahid\u00a0Lotfabadi","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Diseases, Faculty of Medicine Mashhad University of Medical 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