{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T12:05:53Z","timestamp":1784808353423,"version":"3.55.0"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T00:00:00Z","timestamp":1683072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T00:00:00Z","timestamp":1683072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection and the resulting Coronavirus disease 2019 emerged in late 2019 and is responsible for significant morbidity and mortality worldwide. A hallmark of severe COVID\u201019 is exaggerated systemic inflammation, regarded as a \u201ccytokine storm,\u201d which contributes to the damage of various organs, primarily the lungs. The inflammation associated with some viral illnesses is known to alter the expression of drug\u2010metabolizing enzymes and transporters. These alterations can lead to modifications in drug exposure and the processing of various endogenous compounds. Here, we provide evidence to support changes in the mitochondrial ribonucleic acid expression of a subset of drug transporters (84 transporters) in the liver, kidneys, and lungs and metabolizing enzymes (84 enzymes) in the liver in a humanized angiotensin\u2010converting enzyme 2 receptor mouse model. Specifically, three drug transporters (Abca3, Slc7a8, Tap1) and the pro\u2010inflammatory cytokine IL\u20106 were upregulated in the lungs of SARS\u2010CoV\u20102 infected mice. We also found significant downregulation of drug transporters responsible for the movement of xenobiotics in the liver and kidney. Additionally, expression of cytochrome P\u2010450 2f2 which is known to metabolize some pulmonary toxicants, was significantly decreased in the liver of infected mice. The significance of these findings requires further exploration. Our results suggest that further research should emphasize altered drug disposition when investigating therapeutic compounds, whether re\u2010purposed or new chemical entities, in other animal models and ultimately in individuals infected with SARS\u2010CoV\u20102. Moreover, the influence and impact of these changes on the processing of endogenous compounds also require further investigation.<\/jats:p>","DOI":"10.1002\/prp2.1071","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T08:41:40Z","timestamp":1683103300000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The influence of\n                    <scp>SARS\u2010CoV<\/scp>\n                    \u20102 infection on expression of drug\u2010metabolizing enzymes and transporters in a\n                    <scp>hACE2<\/scp>\n                    murine model"],"prefix":"10.1002","volume":"11","author":[{"given":"Kiran","family":"Deshpande","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers The State University of New Jersey  Piscataway New Jersey USA"},{"name":"Center of Excellence in Pharmaceutical Translational Research and Education, Ernest Mario School of Pharmacy, Rutgers The State University of New Jersey  Piscataway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith R.","family":"Lange","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Neuroscience, Rutgers The State University of New Jersey  Piscataway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"Stone","sequence":"additional","affiliation":[{"name":"Department of Entomology, College of Agriculture and Life Sciences, Fralin Life Science Institute Virginia Polytechnic Institute and State University  Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Yohn","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers The State University of New Jersey  Piscataway New Jersey USA"},{"name":"Center of Excellence in Pharmaceutical Translational Research and Education, Ernest Mario School of Pharmacy, Rutgers The State University of New Jersey  Piscataway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Schlesinger","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Medicine, Rutgers Robert Wood Johnson Medical School  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonid","family":"Kagan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers The State University of New Jersey  Piscataway New Jersey USA"},{"name":"Center of Excellence in Pharmaceutical Translational Research and Education, Ernest Mario School of Pharmacy, Rutgers The State University of New Jersey  Piscataway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert 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