{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:52:35Z","timestamp":1786978355617,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870615"],"award-info":[{"award-number":["81870615"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Tacrolimus is an independent risk factor for new\u2010onset diabetes after transplantation (NODAT). This study aimed to identify the mechanisms underlying tacrolimus\u2010induced NODAT. About 80 kidney\u2010transplant patients receiving tacrolimus were divided into NODAT and non\u2010NODAT groups after 1\u2009year. Binary logistic regression was used to identify risk factors for NODAT. Insulin resistance indices were estimated using the homeostasis model assessment. The blood levels of 13 adipocytokines were measured 1\u2009week after transplantation. A tacrolimus\u2010induced diabetes mouse model was used to reveal the underlying mechanisms. The cumulative NODAT incidence was 12.7% at 1\u2009year (median, 6\u2009months; range, 3\u201312\u2009months). Tacrolimus trough levels \u226510\u2009ng\/mL during the first 3\u2009months (odds ratio: 2.54,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.012) were related to NODAT. Insulin resistance indices were higher in NODAT patients than in non\u2010NODAT patients at 3, 6, and 12\u2009months. Monocyte chemoattractant protein (MCP)\u20101 was overexpressed in blood in NODAT patients. In the animal experiments, postprandial blood glucose and insulin levels, insulin pathway protein levels in adipose tissue, MCP\u20101 expression in blood and adipose tissue, and number of macrophages in adipose tissue were markedly higher in tacrolimus\u2010treated mice than in control mice, and these increases were dose\u2010dependent. The expression of endoplasmic reticulum (ER) stress proteins in adipose tissue was increased in a tacrolimus dose\u2010dependent manner. In conclusion, tacrolimus\u2010induced insulin resistance. Tacrolimus trough levels \u226510\u2009ng\/mL during the first 3 postoperative months were an independent risk factor for NODAT. ER stress and MCP\u20101 underlie tacrolimus\u2010induced diabetes.\n                  <\/jats:p>","DOI":"10.1002\/prp2.1081","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T08:54:39Z","timestamp":1684313679000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Endoplasmic reticulum stress in the adipose tissue and monocyte chemoattractant protein\u20101 are involved in tacrolimus\u2010induced diabetes mellitus"],"prefix":"10.1002","volume":"11","author":[{"given":"Xiaoxia","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Endocrinology the Affiliated Hospital of Qingdao University  Qingdao China"},{"name":"Department of Organ Transplantation Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan 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