{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:48:03Z","timestamp":1783698483060,"version":"3.55.0"},"reference-count":60,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T00:00:00Z","timestamp":1688688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009122","name":"Ministry of Higher Education and Scientific Research","doi-asserted-by":"publisher","award":["2021R1I1A1A01044500"],"award-info":[{"award-number":["2021R1I1A1A01044500"]}],"id":[{"id":"10.13039\/100009122","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1C1C1003735"],"award-info":[{"award-number":["2021R1C1C1003735"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A growing number of patients with metabolic disorders are receiving statin and antidiabetic therapies as comedications. A signal of increased risk of myotoxicity due to potential interactions between antidiabetics and statins has been detected in previous studies. To investigate the effects of metformin on myopathy risks when added to preexisting statin therapy in dyslipidemia patients, we performed a retrospective cohort study using the Korean national health insurance data in statin\u2010treated dyslipidemia patients with or without concomitant metformin use. We compared the risk of myopathy in statin\u2009+\u2009metformin users against statin\u2010only users. Hazard ratios (HRs) and 95% confidence intervals (CIs) have been calculated following propensity score (PS) matching between study groups and subsequent stratification per patient factors. We included 4092 and 8161 patients in PS\u2010matched statin\u2009+\u2009metformin and statin\u2010only groups, respectively. The risk of myopathy decreased when metformin was used together with statins (adjusted HR 0.84; 95% CI 0.71\u20130.99). In subgroup analyses per individual statin agent and in stratified risk analyses, no specific statin agents or patient factors were associated with statistically significant myopathy risk. This study found that a comedication with metformin was associated with decreased myopathy risk in statin\u2010treated dyslipidemia patients compared to statin\u2010only users. Our findings suggest that metformin may provide protective effects on potential muscle toxicities induced by statin therapy.<\/jats:p>","DOI":"10.1002\/prp2.1114","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T11:39:27Z","timestamp":1688729967000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of metformin on statin\u2010associated myopathy risks in dyslipidemia patients"],"prefix":"10.1002","volume":"11","author":[{"given":"Keunhyeong","family":"Bak","sequence":"first","affiliation":[{"name":"College of Pharmacy Ajou University  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhyeon","family":"Moon","sequence":"additional","affiliation":[{"name":"College of Pharmacy Ajou University  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjung","family":"Ko","sequence":"additional","affiliation":[{"name":"College of Pharmacy Ajou University  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0635-4374","authenticated-orcid":false,"given":"Yeo Jin","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Pharmacy Kyung Hee University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2388-1122","authenticated-orcid":false,"given":"Sooyoung","family":"Shin","sequence":"additional","affiliation":[{"name":"College of Pharmacy Ajou University  Suwon Republic of Korea"},{"name":"Research Institute of Pharmaceutical Science and Technology (RIPST) Ajou University  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/XCE.0000000000000120"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S169964"},{"key":"e_1_2_12_4_1","unstructured":"The Korean Society of Lipid and Atherosclerosis.Dyslipidemia fact sheet in Korea.2022https:\/\/www.lipid.or.kr\/bbs\/?code=fact_sheetAccessed 10 Feb 2023."},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.E537"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0828-282X(09)70715-9"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1806939"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.08.001"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.08.039"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0b013e32833cd58f"},{"key":"e_1_2_12_11_1","first-page":"1","article-title":"Prescription cholesterol\u2010lowering medication use in adults aged 40 and over: United States, 2003\u20102012","volume":"177","author":"Gu Q","year":"2014","journal-title":"NCHS Data Brief"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(11)70601-6"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.13.1681"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2022.103304"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.06.049"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2012.03.003"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2011.540568"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2013.09.011"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2012.04.012"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht295"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a2286"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61965-6"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4020"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2017.03.001"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13137"},{"key":"e_1_2_12_26_1","unstructured":"European Medicines Agency.Pharmacovigilance Risk Assessment Committee (PRAC). 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