{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T20:50:13Z","timestamp":1794257413781,"version":"4.9.0"},"reference-count":72,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aims to evaluate the efficacy and safety of multiple or single\u2010dosage intravenous ibuprofen (IVIB) in managing postoperative pain and fever in adults who are unable to take oral medications. A systematic review and meta\u2010analysis was conducted based on randomized controlled trials (RCTs) comparing IVIB with placebo or other analgesic and antipyretic medications for postoperative pain and fever management. Data were collected from 8 main databases from the inception to June 2022. Risk of bias assessment was performed, and the GRADE methodology was used to assess the certainty of pooled evidence. Primary outcomes included visual analogue scale (VAS) scores within 24\u2009h postoperative and reduction of temperature. Meta\u2010analyses were conducted to calculate the mean difference (MD) or risk ratios (RR) and 95% CIs. As a result, a total of twenty\u2010three RCTs with 3716 participants were included. For postoperative pain, with moderate\u2010to\u2010low certainty evidence, IVIB was associated with lower postoperative VAS scores than placebo, with MD ranging from \u22123.53 (95% CI, \u22124.32 to \u22122.75) at 0\u2009min to \u22120.96 (95% CI, \u22121.35 to \u22120.57) at 24\u2009h. Compared with intravenous acetaminophen, IVIB demonstrated lower VAS scores (MD, \u22121.54 at 0\u2009min; \u22120.36 at 24\u2009h). For fever, IVIB showed satisfactory antipyretic efficiency in a short period of time, but no difference was observed between IVIB and intravenous acetaminophen. IVIB was well\u2010tolerated for both pain and fever management. In conclusion, moderate\u2010to\u2010low certainty evidence supports the use of IVIB for adults with postoperative pain and fever who are unable to take oral medications.<\/jats:p>","DOI":"10.1002\/prp2.1123","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T12:41:13Z","timestamp":1690980073000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Intravenous ibuprofen in postoperative pain and fever management in adults: A systematic review and meta\u2010analysis of randomized controlled trials"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1208-8217","authenticated-orcid":false,"given":"Pengxiang","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Pharmacy Peking University Third Hospital  Beijing China"},{"name":"Institute for Drug Evaluation Peking University Health Science Center  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4498-8762","authenticated-orcid":false,"given":"Lu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Peking University Third Hospital  Beijing China"},{"name":"Institute for Drug Evaluation Peking University Health Science Center  Beijing China"},{"name":"Department of Pharmacy Yantai Yuhuangding Hospital  Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8096-3154","authenticated-orcid":false,"given":"Ente","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beijing Tongren Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7852-8452","authenticated-orcid":false,"given":"Lanzhi","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Peking University Third Hospital  Beijing China"},{"name":"Department of Pharmacy Jiangbin Hospital of Guangxi Zhuang Autonomous Region  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3432-850X","authenticated-orcid":false,"given":"Shuxia","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Peking University Third Hospital  Beijing China"},{"name":"Department of Pharmacy Tianjin Nankai Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2220-359X","authenticated-orcid":false,"given":"Suodi","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Peking University Third Hospital  Beijing China"},{"name":"Institute for Drug Evaluation Peking University Health Science Center  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,2]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21424"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14966-5"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2015.12.008"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31823c1030"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200969010-00007"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2011.01141.x"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200506000-00027"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmn.2007.11.005"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2014.12.004"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)00203-9"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114147"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2020.05.004"},{"issue":"9","key":"e_1_2_13_14_1","article-title":"Single\u2010dose intravenous ibuprofen for acute postoperative pain in adults","volume":"9","author":"Ferguson MC","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.4097\/kja.21050"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2021\/e2780"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.07.015"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006200"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.5336\/medsci.2018-63679"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-019-04220-1"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/08941939.2017.1386738"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-018-3613-1"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2018.06.030"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154004"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2010.00896.x"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2009.08.026"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuchi.2021.04.019"},{"issue":"8","key":"e_1_2_13_33_1","first-page":"E1199","article-title":"The use of combination paracetamol and ibuprofen in postoperative pain after total knee arthroplasty, a randomized controlled trial","volume":"24","author":"Lubis AM","year":"2021","journal-title":"Pain Physician"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2020.10.029"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-5065-6"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2018.07.023"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jopan.2021.10.018"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2019.04.019"},{"issue":"3","key":"e_1_2_13_39_1","first-page":"310","article-title":"The evaluation of safety and analgesic efficacy of paracetamol and ibuprofen followed by impacted third molar surgery","volume":"7","author":"\u00d6zkan BT","year":"2010","journal-title":"Eur J Gen Med"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2018.09.010"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2019.07.008"},{"issue":"1","key":"e_1_2_13_42_1","first-page":"66","article-title":"Comparison of the clinical effects of ibuprofen and paracetamol used for analgesic purposes in endoscopic retrograde cholangiopancreatography in geriatric patients","volume":"14","author":"Dogan G","year":"2020","journal-title":"Int J Gerontol"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1533-2500.2010.00402.x"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28428-4"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2018.10.008"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S132836"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.3171\/2016.10.JNS161355"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPV.0000000000000740"},{"issue":"9","key":"e_1_2_13_49_1","first-page":"1096","article-title":"Efficacy and safety of ibuprofen injection for postoperative analgesia in patients undergoing general anesthesia: prospective, multicenter, randomized, double\u2010blind, negative\u2010controlled, clinical trial","volume":"40","author":"Zeng Y","year":"2020","journal-title":"Chin J Anesthesiol"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e3182037300"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2010.09-0621"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc9089"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2021.02.057"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.4103\/2452-2473.329629"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e32833853e8"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2008.07.015"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12108"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-017-0607-y"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2017.0898"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X1204000121"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1998.tb05083.x"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-021-00286-5"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1177\/009127000004001005"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.2165\/11319610-000000000-00000"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.2165\/11209470-000000000-00000"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.2165\/11599230-000000000-00000"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp100120"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-0366-z"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2021.01.005"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200512000-00025"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-017-0795-y"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12381"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2014.12.006"}],"container-title":["Pharmacology Research &amp; Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prp2.1123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T01:09:36Z","timestamp":1692320976000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/prp2.1123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":72,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/prp2.1123"],"URL":"https:\/\/doi.org\/10.1002\/prp2.1123","archive":["Portico"],"relation":{},"ISSN":["2052-1707","2052-1707"],"issn-type":[{"value":"2052-1707","type":"print"},{"value":"2052-1707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"2023-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01123"}}