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In this investigation, two animal models, aP2\u2010SREBP\u20101c mice and ob\/ob mice, were used. TGF\u2010\u03b2 pathway showed up\u2010regulated in the inguinal white adipose tissue (iWAT) of the two models. SB431542, a TGF\u2010\u03b2 inhibitor, successfully increased inguinal white adipocyte size by more than 1.5 times and decreased the weight of Peripheral organs including liver, Spleen and Kidney to 73.05%\/62.18%\/73.23% of pre\u2010administration weights. The iWAT showed elevated expression of GLUTs and lipases, followed by a recovery of circulation GLU, TG, NEFA, and GLYCEROL to the wild\u2010type levels in aP2\u2010SREBP\u20101c mice. In contrast, TGF\u2010\u03b2 inhibition did not have similar effects on that of ob\/ob mice. In\u00a0vitro, TGF\u2010\u03b2 blocker treated mature adipocytes had considerably higher levels of glycerol and triglycerides than the control group, whereas GLUTs and lipases expression levels were unchanged. These findings show that inhibiting the abnormally upregulated TGF\u2010\u03b2 pathway will only restore iWAT expansion and ameliorate the global metabolic malfunction of glucose and lipids in lipodystrophy, not obesity.<\/jats:p>","DOI":"10.1002\/prp2.1160","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T11:59:46Z","timestamp":1704369586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The blockade of the <scp>TGF<\/scp>\u2010\u03b2 pathway alleviates abnormal glucose and lipid metabolism of lipodystrophy not obesity"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8143-4561","authenticated-orcid":false,"given":"Wen\u2010Dong","family":"Xu","sequence":"first","affiliation":[{"name":"Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine Guangdong Pharmaceutical University  Guangzhou China"},{"name":"Key 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