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To date, there is no FDA\u2010approved drug for the treatment of mpox. However, tecovirimat, brincidofovir, and cidofovir are the candidate therapies for the management of mpox. Given the safety concerns following the use of these medications, we aimed to review evidence on the clinical considerations of mpox antiviral medications that will be useful to guide clinicians in the treatment approach. Based on the current evidence, tecovirimat has favorable clinical efficacy, safety, and side effect profile and it can be considered as first\u2010line treatment for mpox.<\/jats:p>","DOI":"10.1002\/prp2.1164","type":"journal-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T11:26:25Z","timestamp":1703676385000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Clinical considerations on monkeypox antiviral medications: An overview"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0026-9734","authenticated-orcid":false,"given":"Fariba","family":"Pourkarim","sequence":"first","affiliation":[{"name":"Student Research Committee, Faculty of Pharmacy Tabriz University of Medical Sciences  Tabriz Iran"},{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3653-3653","authenticated-orcid":false,"given":"Taher","family":"Entezari\u2010Maleki","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy Tabriz University of Medical Sciences  Tabriz Iran"},{"name":"Cardiovascular Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,27]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c00069"},{"issue":"2","key":"e_1_2_17_3_1","first-page":"165","article-title":"Human monkeypox, 1970\u20131979","volume":"58","author":"Breman JG","year":"1980","journal-title":"Bull World Health Organ"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0010141"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/498155"},{"issue":"49","key":"e_1_2_17_6_1","first-page":"1168","article-title":"Human monkeypox\u2014Kasai Oriental, Democratic Republic of\u2026","volume":"46","author":"Aplogan A","year":"1997","journal-title":"MMWR: Morb Mortal Wkly Rep"},{"key":"e_1_2_17_7_1","unstructured":"European Centers for Disease Control.Monkeypox cases reported in UK and Portugal.https:\/\/www.ecdc.europa.eu\/en\/news\u2010events\/mpox\u2010cases\u2010reported\u2010uk\u2010and\u2010portugal"},{"key":"e_1_2_17_8_1","unstructured":"Public Health Agency of Canada.Public Health Agency of Canada confirms 2 cases of monkeypox. 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