{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T23:03:37Z","timestamp":1780095817893,"version":"3.54.0"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004697","name":"Hamadan University of Medical Sciences","doi-asserted-by":"publisher","award":["9604132335"],"award-info":[{"award-number":["9604132335"]}],"id":[{"id":"10.13039\/501100004697","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Considering the importance of pain and stress, we decided to investigate the intra\u2010anterior cingulate cortex (ACC) microinjection of histamine and mepyramine alone and concurrently on acute pain induced by hot plate following restraint stress in male rats. 24\u2010gauge, 10\u2009mm stainless steel guide cannula was implanted over the ACC in the incised scalp of 4 groups. Restraint stress in healthy rats produced a significant increase (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) in the pain threshold. The simultaneous microinjection of 4\u2009\u03bcg\/side histamine and 8\u2009\u03bcg\/side mepyramine as a histaminergic system inverse agonist in healthy nonrestraint animals did not affect the pain threshold. Although Histamine decreased the threshold of pain meaningfully, mepyramine elevated it in a significant manner (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). In the restrained animals, intra\u2010ACC microinjection of histamine produced no significant impact on the pain threshold. However, intra\u2010ACC microinjection of mepyramine before histamine, significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01) altered the result and enhanced the threshold of pain. The results of our study demonstrated that histaminergic neurons have an important role in the processing of pain in the ACC following restraint stress.<\/jats:p>","DOI":"10.1002\/prp2.1188","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T12:00:33Z","timestamp":1710417633000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The role of histamine <scp>H<sub>1<\/sub><\/scp> receptor in the anterior cingulate cortex on nociception level following acute restraint stress in male rats"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4376-5009","authenticated-orcid":false,"given":"Roxana","family":"Daniali","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmacology Hamadan University of Medical Sciences  Hamadan 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