{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:25:17Z","timestamp":1784125517801,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:00:00Z","timestamp":1720656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018847","name":"Sel\u00e7uk University Research Foundation","doi-asserted-by":"publisher","award":["22401119"],"award-info":[{"award-number":["22401119"]}],"id":[{"id":"10.13039\/501100018847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gentamicin is an aminoglycoside antibiotic with a rapid bactericidal effect on the treatment of many infections. However, its use at high concentrations for more than 7\u2009days causes nephrotoxic side effects. This study investigated the potential of Resatorvid and alpha lipoic acid (ALA) in mitigating gentamicin\u2010induced nephrotoxicity in rats, considering biochemical, histopathological, and molecular parameters. This study randomly distributed 34 Wistar albino rats into four groups: healthy control (<jats:italic>n<\/jats:italic>\u2009=\u20096), Gentamicin (80\u2009mg\/kg, <jats:italic>n<\/jats:italic>\u2009=\u20097), Gentamicin\u2009+\u2009Sham (%10 hydroalcoholic solution, <jats:italic>n<\/jats:italic>\u2009=\u20097), Gentamicin\u2009+\u2009Resatorvid (5\u2009mg\/kg, <jats:italic>n<\/jats:italic>\u2009=\u20097), and Gentamicin\u2009+\u2009ALA (100\u2009mg\/kg, <jats:italic>n<\/jats:italic>\u2009=\u20097). Resatorvid treatment led to a statistically significant decrease in urinary IL\u201018, KIM\u20101, and NGAL levels, whereas ALA treatment significantly reduced KIM\u20101 levels compared to the gentamicin\u2010only group. Both Resatorvid and ALA showed partial reductions in urine creatinine levels. Moreover, treatments with Resatorvid and ALA resulted in statistically significant decreases in NRF\u20102, CAS\u20103, and NR4A2 expressions. However, only Resatorvid demonstrated a statistically significant decrease in NF\u2010B expression. These findings highlight the potential of Resatorvid in ameliorating gentamicin\u2010induced nephrotoxicity, thereby expanding the therapeutic utility of gentamicin and enhancing its efficacy against infections.<\/jats:p>","DOI":"10.1002\/prp2.1222","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T05:46:13Z","timestamp":1720763173000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Potential effects of Resatorvid and alpha lipoic acid on gentamicin\u2010induced nephrotoxicity in rats"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2738-6911","authenticated-orcid":false,"given":"Burak","family":"Dik","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine Selcuk University  Konya 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