{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:54:59Z","timestamp":1792601699431,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Detailed data on safety associated with drug\u2013drug interactions (DDIs) between Linezolid (LZD) and other antibiotics are limited. The aim of this study was to investigate the safety signals related to these DDIs and to provide a reference for clinically related adverse drug event monitoring. Adverse event (AE) information from 1 January 2004 to 16 June 2022 of the target antibiotics including LZD using alone or in combination with LZD was extracted from the OpenVigil FDA data platform for safety signal analysis. The combined risk ratio model, reporting ratio method, \u03a9 shrinkage measure model, and chi\u2010square statistics model were used to analyze the safety\u2002signals related to DDIs. Meanwhile, we evaluated the correlation and the influence of sex and age between the drug(s) and the target AE detected. There were 18991 AEs related to LZD. There were 2293, 1726, 4449, 821, 2431, 1053, and 463 AE reports when LZD was combined with amikacin, voriconazole, meropenem, clarithromycin, levofloxacin, piperacillin\u2010tazobactam, and azithromycin, respectively. Except for azithromycin, there were positive safety signals related to DDIs between LZD and these antibiotics. These DDIs might influence the incidence of 13, 16, 7, 7, 6, and 15 types of AEs, respectively, and is associated with higher reporting rates of AEs compared with use alone. Moreover, sex and age might influence the occurrence of AEs. We found that the combinations of LZD and other antibiotics are related to multiple AEs, such as hepatotoxicity, drug resistance and electrocardiogram QT prolonged, but further research is still required to investigate their underlying mechanisms. This study can provide a new reference for the safety monitoring of LZD combined with other antibiotics in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/prp2.1236","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T05:34:19Z","timestamp":1721885659000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical drug interactions between linezolid and other antibiotics: For adverse drug event monitoring"],"prefix":"10.1002","volume":"12","author":[{"given":"Ling","family":"Shu","sequence":"first","affiliation":[{"name":"Department of Pharmacy Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing Key Laboratory of Pediatrics  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben\u2010nian","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing Key Laboratory of Pediatrics  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan\u2010ge","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing Key Laboratory of Pediatrics  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010jun","family":"Xie","sequence":"additional","affiliation":[{"name":"Medicine College of Tibet University  Lhasa China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aga","family":"Erbu","sequence":"additional","affiliation":[{"name":"Medicine College of Tibet University  Lhasa China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao\u2010lin","family":"Ai","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing Key Laboratory of Pediatrics  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010tao","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing Key Laboratory of Pediatrics  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5425-3132","authenticated-orcid":false,"given":"Lin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing Key Laboratory of Pediatrics  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,24]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"National Medical Products Administration.Annual Report on National Adverse Drug Reaction Monitoring.2020https:\/\/www.nmpa.gov.cn\/xxgk\/fgwj\/gzwj\/gzwjyp\/20210325170127199.html; [EB\/OL]. 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