{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:04:42Z","timestamp":1782536682571,"version":"3.54.5"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U54\u2010NS100064"],"award-info":[{"award-number":["U54\u2010NS100064"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Post\u2010traumatic epilepsy (PTE) is a life\u2010long complication of traumatic brain injury (TBI). The development of PTE is associated with neurological morbidity and increases the risk of mortality. An aim of EpiBioS4Rx (<jats:italic>Epilepsy Bioinformatics Study for Antiepileptogenic Therapy<\/jats:italic>) was to test potential therapies to prevent the development of PTE in the lateral fluid percussion injury (LFPI) rat model of TBI, in which rats were subjected to injury at the left parietal cortex. Sodium selenate has been reported to be antiepileptogenic post\u2010TBI in rodent models by activating protein phosphatase 2A and reducing phosphorylated tau (p\u2010tau) protein. We aimed to characterize the pharmacokinetics (PK) and brain uptake of sodium selenate using na\u00efve control and LFPI rats. Rats received either a single bolus dose or a single bolus dose followed by a 7\u2010day subcutaneous minipump infusion of sodium selenate. Sodium selenate and selenium concentrations in plasma and brain were analyzed and used for PK estimation and brain exposure assessment. Selenium concentrations rapidly increased after sodium selenate administration, demonstrating biotransformation from sodium selenate to selenium. Sodium selenate and selenium PK parameters were estimated using non\u2010compartmental analysis. Sodium selenate clearance (CL\/F) and volume of distribution (<jats:italic>V<\/jats:italic><jats:sub>d<\/jats:sub>\/<jats:italic>F<\/jats:italic>) varied by dose and route of administration, suggesting differences in bioavailability and nonlinear pharmacokinetics at the doses tested. Brain\u2010to\u2010plasma partition coefficients (AUC<jats:sub>brain<\/jats:sub>\/AUC<jats:sub>plasma<\/jats:sub>) for sodium selenate and selenium were found to be 0.7\u20131.3 and 0.1\u20130.3 following single\u2010dose injection, respectively, indicating active transport of sodium selenate across the blood\u2013brain barrier (BBB).<\/jats:p>","DOI":"10.1002\/prp2.1256","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T06:44:00Z","timestamp":1730961840000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pharmacokinetics and brain uptake of sodium selenate and selenium in na\u00efve rats and a lateral fluid percussion injury rat\u00a0model"],"prefix":"10.1002","volume":"12","author":[{"given":"Chenxu","family":"Li","sequence":"first","affiliation":[{"name":"College of Pharmacy, University of Minnesota Twin Cities  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo M.","family":"Casillas\u2010Espinosa","sequence":"additional","affiliation":[{"name":"Department of Medicine The Royal Melbourne Hospital, The University of Melbourne  Parkville Victoria Australia"},{"name":"Department of Neuroscience Central Clinical School, Monash University  Melbourne Victoria Australia"},{"name":"Department of Neurology The Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Grandizoli","family":"Saletti","sequence":"additional","affiliation":[{"name":"Laboratory of Developmental Epilepsy, Saul R. Korey Department of Neurology Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Chi","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of Minnesota Twin Cities  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Yamakawa","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Central Clinical School, Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Medicine The Royal Melbourne Hospital, The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Hudson","sequence":"additional","affiliation":[{"name":"Department of Medicine The Royal Melbourne Hospital, The University of Melbourne  Parkville Victoria Australia"},{"name":"Department of Neuroscience Central Clinical School, Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Developmental Epilepsy, Saul R. Korey Department of Neurology Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel C.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Medicine The Royal Melbourne Hospital, The University of Melbourne  Parkville Victoria Australia"},{"name":"Department of Neuroscience Central Clinical School, Monash University  Melbourne Victoria Australia"},{"name":"Department of Neurology The Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandy R.","family":"Shultz","sequence":"additional","affiliation":[{"name":"Department of Medicine The Royal Melbourne Hospital, The University of Melbourne  Parkville Victoria Australia"},{"name":"Department of Neuroscience Central Clinical School, Monash University  Melbourne Victoria Australia"},{"name":"Department of Neurology The Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idrish","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Medicine The Royal Melbourne Hospital, The University of Melbourne  Parkville Victoria Australia"},{"name":"Department of Neuroscience Central Clinical School, Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha","family":"Mishra","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of Minnesota Twin Cities  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Cloyd","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of Minnesota Twin Cities  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon L.","family":"Moshe\u00a0\u0301","sequence":"additional","affiliation":[{"name":"Laboratory of Developmental Epilepsy, Saul R. Korey Department of Neurology Albert Einstein College of Medicine  Bronx New York USA"},{"name":"Dominick P. Purpura Department of Neuroscience Albert Einstein College of Medicine  Bronx New York USA"},{"name":"Department of Pediatrics Albert Einstein College of Medicine  Bronx New York USA"},{"name":"Isabelle Rapin Division of Child Neurology Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristea S.","family":"Galanopoulou","sequence":"additional","affiliation":[{"name":"Laboratory of Developmental Epilepsy, Saul R. Korey Department of Neurology Albert Einstein College of Medicine  Bronx New York USA"},{"name":"Dominick P. Purpura Department of Neuroscience Albert Einstein College of Medicine  Bronx New York USA"},{"name":"Isabelle Rapin Division of Child Neurology Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence J.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Department of Medicine The Royal Melbourne Hospital, The University of Melbourne  Parkville Victoria Australia"},{"name":"Department of Neuroscience Central Clinical School, Monash University  Melbourne Victoria Australia"},{"name":"Department of Neurology The Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3613-9904","authenticated-orcid":false,"given":"Lisa D.","family":"Coles","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of Minnesota Twin Cities  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3407"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2018.08.007"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0219137"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60214-2"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13582"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26443"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.44.s10.4.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2016.10.026"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17398"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2003.34902.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2022.0219"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12386"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci9110318"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12738"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr209"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.12.005"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13847"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv053"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2018.06.017"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww116"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.78877"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5491"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2007.09.004"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12721"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12234"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2019.01.006"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2019.101677"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm268"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(89)90247-9"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.03.012"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2018.11.009"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3109\/03602538409015063"},{"key":"e_1_2_11_34_1","volume-title":"StatPearls","author":"Wadhwa RR","year":"2024"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2007.11.011"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2014.1976"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-019-01935-9"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surge.2022.05.001"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.9117"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.122.001377"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009038107"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13656"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605798"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.4155\/tde.11.19"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-019-2745-x"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1017\/jns.2013.17"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300755200"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-014-1380-x"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.630016"}],"container-title":["Pharmacology Research &amp; Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prp2.1256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T09:42:57Z","timestamp":1739266977000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/prp2.1256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,6]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/prp2.1256"],"URL":"https:\/\/doi.org\/10.1002\/prp2.1256","archive":["Portico"],"relation":{},"ISSN":["2052-1707","2052-1707"],"issn-type":[{"value":"2052-1707","type":"print"},{"value":"2052-1707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,6]]},"assertion":[{"value":"2024-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1256"}}