{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:39:22Z","timestamp":1791301162657,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T00:00:00Z","timestamp":1430697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Asubio Pharma Co., Ltd","award":["SUN N8075"],"award-info":[{"award-number":["SUN N8075"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Huntington's disease (<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>) is an inherited genetic disorder, characterized by cognitive dysfunction and abnormal body movements, and at present there is no effective treatment for <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>. Therapeutic options for <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> are limited to symptomatic treatment approaches and there is no cure for this devastating disease. Here, we examined whether <jats:styled-content style=\"fixed-case\">SUN<\/jats:styled-content> N8075, (2<jats:italic>S<\/jats:italic>)\u20101\u2010(4\u2010amino\u20102,3,5\u2010trimethylphenoxy)\u20103\u2010{4\u2010[4\u2010(4\u2010fluorobenzyl)phenyl]\u20101\u2010piperazinyl}\u20102\u2010propanol dimethanesulfonate, which exerts neuroprotective effects by antioxidant effects and induction of <jats:styled-content style=\"fixed-case\">VGF<\/jats:styled-content> nerve growth factor inducible (<jats:styled-content style=\"fixed-case\">VGF<\/jats:styled-content>), has beneficial effects in <jats:styled-content style=\"fixed-case\">STH<\/jats:styled-content>dh cells derived from striatum of knock\u2010in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> mice and R6\/2 <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> mice. In an in vitro study, <jats:styled-content style=\"fixed-case\">SUN<\/jats:styled-content> N8075 inhibited the cell death caused by mutant huntingtin (mHtt) and upregulated the <jats:italic><jats:styled-content style=\"fixed-case\">VGF<\/jats:styled-content><\/jats:italic> <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> level via the phosphorylation of extracellular signal\u2010regulated kinase 1\/2 (<jats:styled-content style=\"fixed-case\">ERK<\/jats:styled-content>1\/2). Furthermore, 30 amino acid of <jats:styled-content style=\"fixed-case\">VGF<\/jats:styled-content> C\u2010terminal peptide, <jats:styled-content style=\"fixed-case\">AQEE<\/jats:styled-content>\u201030 inhibited the cell death and the aggregation of mHtt. In an in vivo study, <jats:styled-content style=\"fixed-case\">SUN<\/jats:styled-content> N8075 improved the survival and the clasping response in the R6\/2 mice. Furthermore, <jats:styled-content style=\"fixed-case\">SUN<\/jats:styled-content> N8075 increased the number of surviving neurons in the striatum of the R6\/2 mice. These findings suggest that <jats:styled-content style=\"fixed-case\">SUN<\/jats:styled-content> N8075 may be an effective candidate for <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> treatments.<\/jats:p>","DOI":"10.1002\/prp2.140","type":"journal-article","created":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T12:05:03Z","timestamp":1434110703000},"source":"Crossref","is-referenced-by-count":17,"title":["<scp>VGF<\/scp> and striatal cell damage in in vitro and in vivo models of Huntington's disease"],"prefix":"10.1002","volume":"3","author":[{"given":"Yasuhiro","family":"Noda","sequence":"first","affiliation":[{"name":"Molecular Pharmacology Department of Biofunctional Evaluation Gifu Pharmaceutical University 1\u201025\u20104 Daigaku\u2010nishi Gifu 501\u20101196 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamitsu","family":"Shimazawa","sequence":"additional","affiliation":[{"name":"Molecular Pharmacology Department of Biofunctional Evaluation Gifu Pharmaceutical University 1\u201025\u20104 Daigaku\u2010nishi Gifu 501\u20101196 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Molecular Pharmacology Department of Biofunctional Evaluation Gifu Pharmaceutical University 1\u201025\u20104 Daigaku\u2010nishi Gifu 501\u20101196 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Tamura","sequence":"additional","affiliation":[{"name":"Asubio Pharma Co., Ltd. 6\u20104\u20103, Minatojima\u2010Minamimachi, Chuo\u2010ku Kobe 650\u20100047 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruyoshi","family":"Inoue","sequence":"additional","affiliation":[{"name":"Asubio Pharma Co., Ltd. 6\u20104\u20103, Minatojima\u2010Minamimachi, Chuo\u2010ku Kobe 650\u20100047 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Tsuruma","sequence":"additional","affiliation":[{"name":"Molecular Pharmacology Department of Biofunctional Evaluation Gifu Pharmaceutical University 1\u201025\u20104 Daigaku\u2010nishi Gifu 501\u20101196 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Hara","sequence":"additional","affiliation":[{"name":"Molecular Pharmacology Department of Biofunctional Evaluation Gifu Pharmaceutical University 1\u201025\u20104 Daigaku\u2010nishi Gifu 501\u20101196 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.09.019"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.11.008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm000143w"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.22.2515"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3920-03.2004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410514"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/77528"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80513-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-20-08942.2002"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.02.013"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2000.7626"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.08.029"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:CEMN.0000023627.79947.22"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2002.1152"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq460"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81369-0"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402141101"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3493-03.2004"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.02.073"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2007.12.025"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.15.5733"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2005.05.006"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(01)02625-7"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1006\/frne.2000.0199"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10229"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015307"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1898-07.2007"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2010.10.032"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M206890200"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059581"}],"container-title":["Pharmacology 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