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This study examines the hypothesis that hypertension aggravates the impairment of <jats:styled-content style=\"fixed-case\">EDH<\/jats:styled-content>\u2010type relaxation due to aging. <jats:styled-content style=\"fixed-case\">EDH<\/jats:styled-content>\u2010type relaxations were studied in superior mesenteric arteries isolated from Wistar Kyoto (<jats:styled-content style=\"fixed-case\">WKY<\/jats:styled-content>) and spontaneously hypertensive (<jats:styled-content style=\"fixed-case\">SHR<\/jats:styled-content>) rats of 12, 36, 60, and 72\u00a0weeks of age. <jats:styled-content style=\"fixed-case\">EDH<\/jats:styled-content>\u2010type relaxations in <jats:styled-content style=\"fixed-case\">WKY<\/jats:styled-content> were reduced with aging, and this was associated with an impairment of the function of small\u2010conductance calcium\u2010activated potassium channels (<jats:styled-content style=\"fixed-case\">SK<jats:sub>C<\/jats:sub><\/jats:styled-content><jats:sub>a<\/jats:sub>) and sodium\u2010potassium <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>ase (Na\u2010K <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>ase). <jats:styled-content style=\"fixed-case\">EDH<\/jats:styled-content>\u2010type relaxation in <jats:styled-content style=\"fixed-case\">SHR<\/jats:styled-content> was smaller than that in <jats:styled-content style=\"fixed-case\">WKY<\/jats:styled-content> arteries, and further reduction occurred with aging. Pharmacological experiments suggested a reduced involvement of <jats:styled-content style=\"fixed-case\">SK<jats:sub>C<\/jats:sub><\/jats:styled-content><jats:sub>a<\/jats:sub> and Na\u2010K <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>ase and activation of adenosine monophosphate\u2010activated protein kinase and silent information regulator T1 (sirtuin\u20101; <jats:styled-content style=\"fixed-case\">SIRT<\/jats:styled-content>1) in mesenteric arteries of 12\u2010week\u2010old <jats:styled-content style=\"fixed-case\">SHR<\/jats:styled-content>. These pharmacological findings suggest that in superior mesenteric arteries of the rat, the reduction in <jats:styled-content style=\"fixed-case\">EDH<\/jats:styled-content>\u2010type relaxation occurs with aging and that such a reduction is exacerbated in hypertension. The latter exacerbation appears to involve proteins associated with the process of cellular senescence and is related to impaired function of <jats:styled-content style=\"fixed-case\">SK<jats:sub>C<\/jats:sub><\/jats:styled-content><jats:sub>a<\/jats:sub> and Na\u2010K <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>ase, a phenomenon that is also observed in mesenteric arteries of older normotensive rats.<\/jats:p>","DOI":"10.1002\/prp2.150","type":"journal-article","created":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T12:05:03Z","timestamp":1434110703000},"source":"Crossref","is-referenced-by-count":33,"title":["Reduced activity of <scp>SK<sub>C<\/sub><\/scp><sub>a<\/sub> and Na\u2010K <scp>ATP<\/scp>ase underlies the accelerated impairment of <scp>EDH<\/scp>\u2010type relaxations in mesenteric arteries of aging spontaneously hypertensive rats"],"prefix":"10.1002","volume":"3","author":[{"given":"Billy W. 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