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Historically, small artery function has preferably been studied in rat isolated mesenteric resistance\u2010sized arteries (<jats:styled-content style=\"fixed-case\">MRA<\/jats:styled-content>) using the wire myograph technique. Although different mouse arteries have been studied using the wire myograph no establishment of optimal settings has yet been performed. Therefore, the purposes of this study were firstly to establish the optimal settings for wire myograph studies of mouse<jats:styled-content style=\"fixed-case\">MRA<\/jats:styled-content>and compare them to those of rat<jats:styled-content style=\"fixed-case\">MRA<\/jats:styled-content>. Second, by surveying the literature, we aimed to evaluate the overall translatability of observed pharmacological vasomotor responses of mouse<jats:styled-content style=\"fixed-case\">MRA<\/jats:styled-content>to those obtained in rat<jats:styled-content style=\"fixed-case\">MRA<\/jats:styled-content>as well as corresponding and different arteries in terms of vessel size and species origin. Our results showed that the optimal conditions for maximal active force development in mouse<jats:styled-content style=\"fixed-case\">MRA<\/jats:styled-content>were not significantly different to those determined in rat<jats:styled-content style=\"fixed-case\">MRA<\/jats:styled-content>. Furthermore, we found that the observed concentration\u2010dependent vasomotor responses of mouse<jats:styled-content style=\"fixed-case\">MRA<\/jats:styled-content>to noradrenaline, phenylephrine, angiotensin<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, sarafotoxin 6c, 5\u2010hydroxytryptamine, carbachol, sodium nitroprusside, and retigabine were generally similar to those described in rat<jats:styled-content style=\"fixed-case\">MRA<\/jats:styled-content>as well as arteries of different sizes and species origin. In summary, the results of this study provide a framework for evidence\u2010based optimization of the isometric wire myograph setup to mouse<jats:styled-content style=\"fixed-case\">MRA<\/jats:styled-content>. Additionally, in terms of translational value, our study suggests that mouse<jats:styled-content style=\"fixed-case\">MRA<\/jats:styled-content>can be applied as a useful model for studying vascular reactivity.<\/jats:p>","DOI":"10.1002\/prp2.200","type":"journal-article","created":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T12:58:28Z","timestamp":1450789108000},"source":"Crossref","is-referenced-by-count":11,"title":["Translational value of mechanical and vasomotor properties of mouse isolated mesenteric resistance\u2010sized arteries"],"prefix":"10.1002","volume":"3","author":[{"given":"Emilie M.","family":"Outzen","sequence":"first","affiliation":[{"name":"Department of Drug Design and Pharmacology Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Zaki","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahareh","family":"Abdolalizadeh","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anette","family":"Sams","sequence":"additional","affiliation":[{"name":"Department of Diabetic Complications Biology Novo Nordisk A\/S Maaloev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harrie C. 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