{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:08:15Z","timestamp":1787314095292,"version":"build-2736575974"},"reference-count":96,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T00:00:00Z","timestamp":1482451200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T00:00:00Z","timestamp":1482451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001734","name":"K\u00f8benhavns Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Philip Morris External Research Program (KAK)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacol Res Perspect"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1002\/prp2.282","type":"journal-article","created":{"date-parts":[[2016,12,24]],"date-time":"2016-12-24T14:30:04Z","timestamp":1482589804000},"page":"e00282","source":"Crossref","is-referenced-by-count":8,"title":["Acute cocaine exposure elicits rises in calcium in arousal-related laterodorsal tegmental neurons"],"prefix":"10.1002","volume":"5","author":[{"given":"Mads \u00d8dum","family":"Lambert","sequence":"first","affiliation":[{"name":"Department of Drug Design and Pharmacology; Faculty of Health Sciences; Universitetsparken 2; University of Copenhagen; Copenhagen 2100 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theis H\u00f8jland","family":"Ipsen","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology; Faculty of Health Sciences; Universitetsparken 2; University of Copenhagen; Copenhagen 2100 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi Anne","family":"Kohlmeier","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology; Faculty of Health Sciences; Universitetsparken 2; University of Copenhagen; Copenhagen 2100 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,23]]},"reference":[{"key":"10.1002\/prp2.282-BIB0001|prp2282-cit-0001","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1038\/sj.npp.1300443","article-title":"Does prenatal nicotine exposure sensitize the brain to nicotine-induced neurotoxicity in adolescence?","volume":"29","author":"Abreu-Villaca","year":"2004a","journal-title":"Neuropsychopharmacology"},{"key":"10.1002\/prp2.282-BIB0002|prp2282-cit-0002","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/sj.npp.1300401","article-title":"Prenatal nicotine exposure alters the response to nicotine administration in adolescence: effects\u00a0on cholinergic systems during exposure and\u00a0withdrawal","volume":"29","author":"Abreu-Villaca","year":"2004b","journal-title":"Neuropsychopharmacology"},{"key":"10.1002\/prp2.282-BIB0003|prp2282-cit-0003","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0006-8993(84)90354-8","article-title":"Site-specific enhancement and suppression of desynchronized sleep signs following cholinergic stimulation of three brainstem regions","volume":"306","author":"Baghdoyan","year":"1984","journal-title":"Brain Res"},{"key":"10.1002\/prp2.282-BIB0004|prp2282-cit-0004","doi-asserted-by":"crossref","first-page":"4664","DOI":"10.1523\/JNEUROSCI.5502-08.2009","article-title":"Activity profiles of cholinergic and intermingled GABAergic and putative glutamatergic neurons in the pontomesencephalic tegmentum of urethane-anesthetized rats","volume":"29","author":"Boucetta","year":"2009","journal-title":"J Neurosci"},{"key":"10.1002\/prp2.282-BIB0005|prp2282-cit-0005","doi-asserted-by":"crossref","first-page":"4708","DOI":"10.1523\/JNEUROSCI.2617-13.2014","article-title":"Discharge profiles across the sleep-waking cycle of identified cholinergic, GABAergic, and glutamatergic neurons in the pontomesencephalic tegmentum of the rat","volume":"34","author":"Boucetta","year":"2014","journal-title":"J Neurosci"},{"key":"10.1002\/prp2.282-BIB0006|prp2282-cit-0006","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/0306-4522(87)90239-9","article-title":"Intracellular studies on the dopamine-induced firing inhibition of neostriatal neurons in\u00a0vitro: evidence for D1 receptor involvement","volume":"20","author":"Calabresi","year":"1987","journal-title":"Neuroscience"},{"key":"10.1002\/prp2.282-BIB0007|prp2282-cit-0007","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1038\/ncomms3720","article-title":"Methylphenidate amplifies the potency and reinforcing effects of amphetamines by increasing dopamine transporter expression","volume":"4","author":"Calipari","year":"2013","journal-title":"Nat Commun"},{"key":"10.1002\/prp2.282-BIB0008|prp2282-cit-0008","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s00213-013-2967-2","article-title":"Mephedrone and methylenedioxypyrovalerone (MDPV), major constituents of \u201cbath salts\u201d, produce opposite effects at the human dopamine transporter","volume":"227","author":"Cameron","year":"2013a","journal-title":"Psychopharmacology"},{"key":"10.1002\/prp2.282-BIB0009|prp2282-cit-0009","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1111\/bph.12061","article-title":"Bath salts components mephedrone and methylenedioxypyrovalerone (MDPV) act synergistically at the human dopamine transporter","volume":"168","author":"Cameron","year":"2013b","journal-title":"Br J Pharmacol"},{"key":"10.1002\/prp2.282-BIB0010|prp2282-cit-0010","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1152\/jn.00307.2013","article-title":"The lateral mesopontine tegmentum regulates both tonic and phasic activity of VTA dopamine neurons","volume":"110","author":"Chen","year":"2013","journal-title":"J Neurophysiol"},{"key":"10.1002\/prp2.282-BIB0011|prp2282-cit-0011","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1017\/S204017441400049X","article-title":"Electrophysiological changes in laterodorsal tegmental neurons associated with prenatal nicotine exposure: implications for heightened susceptibility to addict to drugs of abuse","volume":"6","author":"Christensen","year":"2015","journal-title":"J Dev Orig Health Dis"},{"key":"10.1002\/prp2.282-BIB0012|prp2282-cit-0012","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1523\/JNEUROSCI.15-03-01714.1995","article-title":"The dopamine transporter: immunochemical characterization and localization in brain","volume":"15","author":"Ciliax","year":"1995","journal-title":"J Neurosci"},{"key":"10.1002\/prp2.282-BIB0100|prp2282-cit-0100","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1152\/jn.2000.83.1.90","article-title":"Cumulative Effects of Glutamate Microstimulation on Ca2+ Responses of CA1 Hippocampal Pyramidal Neurons in Slice","volume":"83","author":"Connor","year":"2000","journal-title":"J Neurophysiol"},{"key":"10.1002\/prp2.282-BIB0013|prp2282-cit-0013","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0361-9230(90)90072-8","article-title":"Afferent and Efferent Connections of the Laterodorsal Tegmental Nucleus in the Rat","volume":"25","author":"Cornwall","year":"1990","journal-title":"Brain Res Bull"},{"key":"10.1002\/prp2.282-BIB0014|prp2282-cit-0014","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.1523\/JNEUROSCI.5071-13.2014","article-title":"A major external source of cholinergic innervation of the striatum and nucleus accumbens originates in the brainstem","volume":"34","author":"Dautan","year":"2014","journal-title":"J Neurosci"},{"key":"10.1002\/prp2.282-BIB0015|prp2282-cit-0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnana.2016.00001","article-title":"Extrinsic sources of cholinergic innervation of the striatal complex: a whole-brain mapping analysis","volume":"10","author":"Dautan","year":"2016a","journal-title":"Front Neuroanat"},{"key":"10.1002\/prp2.282-BIB0016|prp2282-cit-0016","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/nn.4335","article-title":"Segregated cholinergic transmission modulates dopamine neurons integrated in distinct functional circuits","volume":"19","author":"Dautan","year":"2016b","journal-title":"Nat Neurosci"},{"key":"10.1002\/prp2.282-BIB0017|prp2282-cit-0017","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/31960","article-title":"Calcium oscillations increase the efficiency and specificity of gene expression","volume":"392","author":"Dolmetsch","year":"1998","journal-title":"Nature"},{"key":"10.1002\/prp2.282-BIB0018|prp2282-cit-0018","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.resp.2004.02.011","article-title":"Pontine and basal forebrain cholinergic interaction: implications for sleep and breathing","volume":"143","author":"Douglas","year":"2004","journal-title":"Respir Physiol Neurobiol"},{"key":"10.1002\/prp2.282-BIB0019|prp2282-cit-0019","doi-asserted-by":"crossref","first-page":"11522","DOI":"10.1523\/JNEUROSCI.3612-06.2006","article-title":"Cocaine increases the intracellular calcium concentration in brain independently of its cerebrovascular effects","volume":"26","author":"Du","year":"2006","journal-title":"J Neurosci"},{"key":"10.1002\/prp2.282-BIB0020|prp2282-cit-0020","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1523\/JNEUROSCI.08-01-00100.1988","article-title":"Electrophysiological Effects of Cocaine in the Mesoaccumbens Dopamine System - Studies in the Ventral Tegmental Area","volume":"8","author":"Einhorn","year":"1988","journal-title":"J Neurosci"},{"key":"10.1002\/prp2.282-BIB0021|prp2282-cit-0021","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1196\/annals.1300.032","article-title":"Rapid AMPAR\/NMDAR response to amphetamine: a detectable increase in AMPAR\/NMDAR ratios in the ventral tegmental area is detectable after amphetamine injection","volume":"1003","author":"Faleiro","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"10.1002\/prp2.282-BIB0022|prp2282-cit-0022","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1038\/sj.npp.1300495","article-title":"Rapid synaptic plasticity of glutamatergic synapses on dopamine neurons in the ventral tegmental area in response to acute amphetamine injection","volume":"29","author":"Faleiro","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1002\/prp2.282-BIB0023|prp2282-cit-0023","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1038\/npp.2012.17","article-title":"Cocaine self-administration produces pharmacodynamic tolerance: differential effects on the potency of dopamine transporter blockers, releasers, and methylphenidate","volume":"37","author":"Ferris","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1002\/prp2.282-BIB0024|prp2282-cit-0024","doi-asserted-by":"crossref","first-page":"3596","DOI":"10.1046\/j.1460-9568.2000.00250.x","article-title":"Laterodorsal tegmental stimulation elicits dopamine efflux in the rat nucleus accumbens by activation of acetylcholine and glutamate receptors in the ventral tegmental area","volume":"12","author":"Forster","year":"2000","journal-title":"Eur J Neurosci"},{"key":"10.1002\/prp2.282-BIB0025|prp2282-cit-0025","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0306-4522(02)00365-2","article-title":"Effects of laterodorsal tegmentum excitotoxic lesions on behavioral and dopamine responses evoked by morphine and d-amphetamine","volume":"114","author":"Forster","year":"2002a","journal-title":"Neuroscience"},{"key":"10.1002\/prp2.282-BIB0026|prp2282-cit-0026","doi-asserted-by":"crossref","first-page":"RC190","DOI":"10.1523\/JNEUROSCI.22-01-j0001.2002","article-title":"M5 muscarinic receptors are required for prolonged accumbal dopamine release after electrical stimulation of the pons in mice","volume":"22","author":"Forster","year":"2002b","journal-title":"J Neurosci"},{"key":"10.1002\/prp2.282-BIB0027|prp2282-cit-0027","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1038\/sj.npp.1301650","article-title":"Prominent activation of brainstem and pallidal afferents of the ventral tegmental area by cocaine","volume":"33","author":"Geisler","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1002\/prp2.282-BIB0028|prp2282-cit-0028","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1124\/mol.66.1.137","article-title":"Intracellular Ca2+ regulates amphetamine-induced dopamine efflux and currents mediated by the human dopamine transporter","volume":"66","author":"Gnegy","year":"2004","journal-title":"Mol Pharmacol"},{"key":"10.1002\/prp2.282-BIB0029|prp2282-cit-0029","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.tins.2007.03.003","article-title":"Regulation of firing of dopaminergic neurons and control of goal-directed behaviors","volume":"30","author":"Grace","year":"2007","journal-title":"Trends Neurosci"},{"key":"10.1002\/prp2.282-BIB0030|prp2282-cit-0030","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1152\/jn.00383.2013","article-title":"Evidence for a role of Nav1.6 in facilitating increases in neuronal hyperexcitability during epileptogenesis","volume":"110","author":"Hargus","year":"2013","journal-title":"J Neurophysiol"},{"key":"10.1002\/prp2.282-BIB0031|prp2282-cit-0031","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1177\/37.5.2703701","article-title":"Histochemical characterization of neuronal NADPH-diaphorase","volume":"37","author":"Hope","year":"1989","journal-title":"J Histochem Cytochem"},{"key":"10.1002\/prp2.282-BIB0032|prp2282-cit-0032","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1073\/pnas.88.7.2811","article-title":"Neuronal NADPH diaphorase is a nitric oxide synthase","volume":"88","author":"Hope","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/prp2.282-BIB0033|prp2282-cit-0033","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0079-6123(08)62381-X","article-title":"The organization of central cholinergic systems and their functional importance in sleep-waking states","volume":"98","author":"Jones","year":"1993","journal-title":"Prog Brain Res"},{"key":"10.1002\/prp2.282-BIB0034|prp2282-cit-0034","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1111\/ejn.12855","article-title":"Intrinsic membrane plasticity via increased persistent sodium conductance of cholinergic neurons in the rat laterodorsal tegmental nucleus contributes to cocaine-induced addictive behavior","volume":"41","author":"Kamii","year":"2015","journal-title":"Eur J Neurosci"},{"key":"10.1002\/prp2.282-BIB0035|prp2282-cit-0035","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1124\/jpet.104.071068","article-title":"Repeated amphetamine couples norepinephrine transporter and calcium channel activities in PC12 cells","volume":"311","author":"Kantor","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1002\/prp2.282-BIB0036|prp2282-cit-0036","first-page":"427","article-title":"Conformational Requirements for Blocking Uptake of Catecholamines and Serotonin into Crude Rat-Brain Synaptosomes","volume":"35","author":"Koe","year":"1976a","journal-title":"Fed Proc"},{"key":"10.1002\/prp2.282-BIB0037|prp2282-cit-0037","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0022-3565(25)30726-3","article-title":"Molecular-Geometry of Inhibitors of Uptake of Catecholamines and Serotonin in Synaptosomal Preparations of Rat-Brain","volume":"199","author":"Koe","year":"1976b","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1002\/prp2.282-BIB0038|prp2282-cit-0038","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1155\/2013\/604847","article-title":"Off the beaten path: drug addiction and the pontine laterodorsal tegmentum","volume":"2013","author":"Kohlmeier","year":"2013","journal-title":"ISRN Neuroscience"},{"key":"10.1002\/prp2.282-BIB0039|prp2282-cit-0039","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1152\/jn.00076.2004","article-title":"Hypocretin\/orexin peptide signaling in the ascending arousal system: elevation of intracellular calcium in the mouse dorsal raphe and laterodorsal tegmentum","volume":"92","author":"Kohlmeier","year":"2004","journal-title":"J Neurophysiol"},{"key":"10.1002\/prp2.282-BIB0040|prp2282-cit-0040","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.neuroscience.2013.06.011","article-title":"Gamma-Hydroxybutyric acid induces actions via the GABAB receptor in arousal and motor control-related nuclei: implications for therapeutic actions in behavioral state disorders","volume":"248","author":"Kohlmeier","year":"2013","journal-title":"Neuroscience"},{"key":"10.1002\/prp2.282-BIB0041|prp2282-cit-0041","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1021\/cn4001236","article-title":"\u201cDeconstruction\u201d of the abused synthetic cathinone methylenedioxypyrovalerone (MDPV) and an examination of effects at the human dopamine transporter","volume":"4","author":"Kolanos","year":"2013","journal-title":"ACS Chem Neurosci"},{"key":"10.1002\/prp2.282-BIB0042|prp2282-cit-0042","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0306-4522(00)00004-X","article-title":"Modulation of presumed cholinergic mesopontine tegmental neurons by acetylcholine and monoamines applied iontophoretically in unanesthetized cats","volume":"96","author":"Koyama","year":"2000","journal-title":"Neuroscience"},{"key":"10.1002\/prp2.282-BIB0043|prp2282-cit-0043","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1111\/ejn.12296","article-title":"Cocaine exposure enhances excitatory synaptic drive to cholinergic neurons in the laterodorsal tegmental nucleus","volume":"38","author":"Kurosawa","year":"2013","journal-title":"Eur J Neurosci"},{"key":"10.1002\/prp2.282-BIB0044|prp2282-cit-0044","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/nature11527","article-title":"Input-specific control of reward and aversion in the ventral tegmental area","volume":"491","author":"Lammel","year":"2012","journal-title":"Nature"},{"key":"10.1002\/prp2.282-BIB0045|prp2282-cit-0045","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1007\/s00221-006-0511-x","article-title":"Upregulation of persistent and ramp sodium current in dorsal horn neurons after spinal cord injury","volume":"174","author":"Lampert","year":"2006","journal-title":"Exp Brain Res"},{"key":"10.1002\/prp2.282-BIB0046|prp2282-cit-0046","doi-asserted-by":"crossref","first-page":"35671","DOI":"10.1074\/jbc.M401923200","article-title":"Dopamine D1 and D2 receptor Co-activation generates a novel phospholipase C-mediated calcium signal","volume":"279","author":"Lee","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1002\/prp2.282-BIB0047|prp2282-cit-0047","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.pbb.2006.11.006","article-title":"Increased nicotine self-administration following prenatal exposure in female rats","volume":"85","author":"Levin","year":"2006","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1002\/prp2.282-BIB0048|prp2282-cit-0048","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/31965","article-title":"Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression","volume":"392","author":"Li","year":"1998","journal-title":"Nature"},{"key":"10.1002\/prp2.282-BIB0049|prp2282-cit-0049","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.jpain.2013.01.778","article-title":"Protein kinase B\/Akt is required for complete Freund's adjuvant-induced upregulation of Nav1.7 and Nav1.8 in primary sensory neurons","volume":"14","author":"Liang","year":"2013","journal-title":"J Pain"},{"key":"10.1002\/prp2.282-BIB0050|prp2282-cit-0050","doi-asserted-by":"crossref","first-page":"5167","DOI":"10.1073\/pnas.0510715103","article-title":"The laterodorsal tegmentum is essential for burst firing of ventral tegmental area dopamine neurons","volume":"103","author":"Lodge","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"issue":"11","key":"10.1002\/prp2.282-BIB0051|prp2282-cit-0051","doi-asserted-by":"crossref","DOI":"10.1101\/pdb.prot5316","article-title":"Imaging action potentials with calcium indicators","volume":"2009","author":"MacLean","year":"2009","journal-title":"Cold Spring Harb Protoc"},{"key":"10.1002\/prp2.282-BIB0052|prp2282-cit-0052","doi-asserted-by":"crossref","first-page":"S438","DOI":"10.1038\/bjp.2008.5","article-title":"The cholinergic mesopontine tegmentum is a relatively neglected nicotinic master modulator of the dopaminergic system: relevance to drugs of abuse and pathology","volume":"153","author":"Maskos","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1002\/prp2.282-BIB0053|prp2282-cit-0053","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1017\/S2040174414000439","article-title":"Prenatal nicotine is associated with reduced AMPA and NMDA receptor-mediated rises in calcium within the laterodorsal tegmentum: a pontine nucleus involved in addiction processes","volume":"6","author":"McNair","year":"2015","journal-title":"J Dev Orig Health Dis"},{"key":"10.1002\/prp2.282-BIB0054|prp2282-cit-0054","doi-asserted-by":"crossref","first-page":"72","DOI":"10.2174\/1874473710902010076","article-title":"The role of glial cells in drug abuse","volume":"2","author":"Miguel-Hidalgo","year":"2009","journal-title":"Curr Drug Abuse Rev"},{"key":"10.1002\/prp2.282-BIB0055|prp2282-cit-0055","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jad.2010.06.003","article-title":"Glial and glutamatergic markers in depression, alcoholism, and their comorbidity","volume":"127","author":"Miguel-Hidalgo","year":"2010","journal-title":"J Affect Disord"},{"key":"10.1002\/prp2.282-BIB0056|prp2282-cit-0056","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/S0022-3565(25)24623-7","article-title":"Prenatal exposure to nicotine via maternal infusions: effects on development of catecholamine systems","volume":"244","author":"Navarro","year":"1988","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1002\/prp2.282-BIB0057|prp2282-cit-0057","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/S0022-3565(25)21095-3","article-title":"Effects of prenatal nicotine exposure on development of central and peripheral cholinergic neurotransmitter systems. Evidence for cholinergic trophic influences in developing brain","volume":"251","author":"Navarro","year":"1989a","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1002\/prp2.282-BIB0058|prp2282-cit-0058","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0361-9230(89)90146-9","article-title":"Prenatal exposure to nicotine impairs nervous system development at a dose which does not affect viability or growth","volume":"23","author":"Navarro","year":"1989b","journal-title":"Brain Res Bull"},{"key":"10.1002\/prp2.282-BIB0059|prp2282-cit-0059","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/cne.20417","article-title":"Laterodorsal tegmental projections to identified cell populations in the rat ventral tegmental area","volume":"483","author":"Omelchenko","year":"2005","journal-title":"J Comp Neurol"},{"key":"10.1002\/prp2.282-BIB0060|prp2282-cit-0060","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/cne.20852","article-title":"Cholinergic axons in the rat ventral tegmental area synapse preferentially onto mesoaccumbens dopamine neurons","volume":"494","author":"Omelchenko","year":"2006","journal-title":"J Comp Neurol"},{"key":"10.1002\/prp2.282-BIB0061|prp2282-cit-0061","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ijdevneu.2004.05.009","article-title":"In utero nicotine exposure causes persistent, gender-dependant changes in locomotor activity and sensitivity to nicotine in C57Bl\/6 mice","volume":"22","author":"Pauly","year":"2004","journal-title":"Int J Dev Neurosci"},{"key":"10.1002\/prp2.282-BIB0062|prp2282-cit-0062","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1073\/pnas.0604049104","article-title":"D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq\/11 in the striatum","volume":"104","author":"Rashid","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/prp2.282-BIB0063|prp2282-cit-0063","first-page":"404","article-title":"The Cocaine Receptor - Behavioral Potency Correlates with Monoamine Uptake Inhibition","volume":"46","author":"Ritz","year":"1987","journal-title":"Fed Proc"},{"key":"10.1002\/prp2.282-BIB0064|prp2282-cit-0064","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1126\/science.2820058","article-title":"Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine","volume":"237","author":"Ritz","year":"1987","journal-title":"Science"},{"key":"10.1002\/prp2.282-BIB0065|prp2282-cit-0065","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0896-6273(03)00021-7","article-title":"Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons","volume":"37","author":"Saal","year":"2003","journal-title":"Neuron"},{"key":"10.1002\/prp2.282-BIB0066|prp2282-cit-0066","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1111\/j.1460-9568.2009.06904.x","article-title":"The limbic circuitry underlying cocaine seeking encompasses the PPTg\/LDT","volume":"30","author":"Schmidt","year":"2009","journal-title":"Eur J Neurosci"},{"key":"10.1002\/prp2.282-BIB0067|prp2282-cit-0067","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/cne.903230307","article-title":"Afferent connections of the laterodorsal and the pedunculopontine tegmental nuclei in the rat: a retro- and antero-grade transport and immunohistochemical study","volume":"323","author":"Semba","year":"1992","journal-title":"J Comp Neurol"},{"key":"10.1002\/prp2.282-BIB0068|prp2282-cit-0068","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.neuropharm.2014.01.019","article-title":"Critical role of cholinergic transmission from the laterodorsal tegmental nucleus to the ventral tegmental area in cocaine-induced place preference","volume":"79","author":"Shinohara","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1002\/prp2.282-BIB0069|prp2282-cit-0069","doi-asserted-by":"crossref","first-page":"5575","DOI":"10.1523\/JNEUROSCI.4050-13.2014","article-title":"Biphasic mechanisms of amphetamine action at the dopamine terminal","volume":"34","author":"Siciliano","year":"2014","journal-title":"J Neurosci"},{"key":"10.1002\/prp2.282-BIB0070|prp2282-cit-0070","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/0024-3205(91)90113-P","article-title":"Chronic prenatal nicotine exposure sensitizes rat brain to acute postnatal nicotine challenge as assessed with ornithine decarboxylase","volume":"49","author":"Slotkin","year":"1991","journal-title":"Life Sci"},{"key":"10.1002\/prp2.282-BIB0071|prp2282-cit-0071","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/sj.npp.1300544","article-title":"Effects of prenatal nicotine exposure on primate brain development and attempted amelioration with supplemental choline or vitamin C: neurotransmitter receptors, cell signaling and cell development biomarkers in fetal brain regions of rhesus monkeys","volume":"30","author":"Slotkin","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1002\/prp2.282-BIB0072|prp2282-cit-0072","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1038\/sj.npp.1300988","article-title":"Prenatal nicotine exposure alters the responses to subsequent nicotine administration and withdrawal in adolescence: Serotonin receptors and cell signaling","volume":"31","author":"Slotkin","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1002\/prp2.282-BIB0073|prp2282-cit-0073","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1038\/sj.npp.1301231","article-title":"Permanent, sex-selective effects of prenatal or adolescent nicotine exposure, separately or sequentially, in rat brain regions: indices of cholinergic and serotonergic synaptic function, cell signaling, and neural cell number and size at 6\u00a0months of age","volume":"32","author":"Slotkin","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1002\/prp2.282-BIB0074|prp2282-cit-0074","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.ntt.2011.02.001","article-title":"Prenatal nicotine exposure in rhesus monkeys compromises development of brainstem and cardiac monoamine pathways involved in perinatal adaptation and sudden infant death syndrome: amelioration by vitamin C","volume":"33","author":"Slotkin","year":"2011","journal-title":"Neurotoxicol Teratol"},{"key":"10.1002\/prp2.282-BIB0075|prp2282-cit-0075","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.1523\/JNEUROSCI.15-05-03905.1995","article-title":"Dopamine enhances glutamate-activated currents in spinal motoneurons","volume":"15","author":"Smith","year":"1995","journal-title":"J Neurosci"},{"key":"10.1002\/prp2.282-BIB0076|prp2282-cit-0076","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1124\/mol.105.012229","article-title":"D1 and D2 dopamine receptors form heterooligomers and cointernalize after selective activation of either receptor","volume":"68","author":"So","year":"2005","journal-title":"Mol Pharmacol"},{"key":"10.1002\/prp2.282-BIB0077|prp2282-cit-0077","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0968-0004(99)01383-3","article-title":"The Ca-calmodulin-dependent protein kinase cascade","volume":"24","author":"Soderling","year":"1999","journal-title":"Trends Biochem Sci"},{"key":"10.1002\/prp2.282-BIB0078|prp2282-cit-0078","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s002130050818","article-title":"Effects of continuous oral nicotine administration on brain nicotinic receptors and responsiveness to nicotine in C57Bl\/6 mice","volume":"141","author":"Sparks","year":"1999","journal-title":"Psychopharmacology"},{"key":"10.1002\/prp2.282-BIB0079|prp2282-cit-0079","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.brainres.2015.04.021","article-title":"Optogenetic excitation of LDTg axons in the VTA reinforces operant responding in rats","volume":"1614","author":"Steidl","year":"2015","journal-title":"Brain Res"},{"key":"10.1002\/prp2.282-BIB0080|prp2282-cit-0080","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.bbr.2015.02.049","article-title":"Increased latencies to initiate cocaine self-administration following laterodorsal tegmental nucleus lesions","volume":"287","author":"Steidl","year":"2015","journal-title":"Behav Brain Res"},{"key":"10.1002\/prp2.282-BIB0081|prp2282-cit-0081","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0361-9230(99)00119-7","article-title":"Brainstem activation of thalamocortical systems","volume":"50","author":"Steriade","year":"1999a","journal-title":"Brain Res Bull"},{"key":"10.1002\/prp2.282-BIB0082|prp2282-cit-0082","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0166-2236(99)01407-1","article-title":"Coherent oscillations and short-term plasticity in corticothalamic networks","volume":"22","author":"Steriade","year":"1999b","journal-title":"Trends Neurosci"},{"key":"10.1002\/prp2.282-BIB0083|prp2282-cit-0083","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1126\/science.270.5236.593","article-title":"Neurotrophins and neuronal plasticity","volume":"270","author":"Thoenen","year":"1995","journal-title":"Science"},{"key":"10.1002\/prp2.282-BIB0084|prp2282-cit-0084","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/35079077","article-title":"Single cocaine exposure in\u00a0vivo induces long-term potentiation in dopamine neurons","volume":"411","author":"Ungless","year":"2001","journal-title":"Nature"},{"key":"10.1002\/prp2.282-BIB0085|prp2282-cit-0085","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jneumeth.2016.01.020","article-title":"Comparison of bNOS and chat immunohistochemistry in the laterodorsal tegmentum (LDT) and the pedunculopontine tegmentum (PPT) of the mouse from brain slices prepared for electrophysiology","volume":"263","author":"Veleanu","year":"2016","journal-title":"J Neurosci Methods"},{"key":"10.1002\/prp2.282-BIB0086|prp2282-cit-0086","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0304-3940(83)90124-6","article-title":"NADPH-diaphorase: a selective histochemical marker for the cholinergic neurons of the pontine reticular formation","volume":"43","author":"Vincent","year":"1983","journal-title":"Neurosci Lett"},{"key":"10.1002\/prp2.282-BIB0087|prp2282-cit-0087","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0306-4522(86)90234-4","article-title":"Neuropeptides and NADPH-diaphorase activity in the ascending cholinergic reticular system of the rat","volume":"17","author":"Vincent","year":"1986","journal-title":"Neuroscience"},{"key":"10.1002\/prp2.282-BIB0088|prp2282-cit-0088","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1460-9568.2008.06576.x","article-title":"Pedunculopontine and laterodorsal tegmental nuclei contain distinct populations of cholinergic, glutamatergic and GABAergic neurons in the rat","volume":"29","author":"Wang","year":"2009","journal-title":"Eur J Neurosci"},{"key":"10.1002\/prp2.282-BIB0089|prp2282-cit-0089","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1073\/pnas.88.5.1859","article-title":"D1 and D2 dopamine receptor mRNA in rat brain","volume":"88","author":"Weiner","year":"1991a","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/prp2.282-BIB0090|prp2282-cit-0090","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1073\/pnas.88.5.1859","article-title":"D1 and D2 dopamine receptor mRNA in rat brain","volume":"88","author":"Weiner","year":"1991b","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/prp2.282-BIB0091|prp2282-cit-0091","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/0014-2999(90)94188-4","article-title":"Repeated Stimulation of Dopamine-D1 Receptors Enhances the Effects of Dopamine Receptor Agonists","volume":"191","author":"White","year":"1990","journal-title":"Eur J Pharmacol"},{"key":"10.1002\/prp2.282-BIB0092|prp2282-cit-0092","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.neuron.2016.03.028","article-title":"Cholinergic Mesopontine Signals Govern Locomotion and Reward through Dissociable Midbrain Pathways","volume":"90","author":"Xiao","year":"2016","journal-title":"Neuron"},{"key":"10.1002\/prp2.282-BIB0093|prp2282-cit-0093","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1113\/jphysiol.2012.230268","article-title":"Cocaine potentiates excitatory drive in the\u00a0perifornical\/lateral hypothalamus","volume":"590","author":"Yeoh","year":"2012","journal-title":"J Physiol"},{"key":"10.1002\/prp2.282-BIB0094|prp2282-cit-0094","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1101\/pdb.prot5650","article-title":"Imaging action potentials with calcium indicators","volume":"2011","author":"Yuste","year":"2011","journal-title":"Cold Spring Harb Protoc"},{"key":"10.1002\/prp2.282-BIB0095|prp2282-cit-0095","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0304-3940(96)12925-6","article-title":"Acute cocaine results in rapid rises in intracellular free calcium concentration in canine cerebral vascular smooth muscle cells: possible relation to etiology of stroke","volume":"215","author":"Zhang","year":"1996","journal-title":"Neurosci Lett"}],"container-title":["Pharmacology Research &amp; Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fprp2.282","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/prp2.282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T17:33:45Z","timestamp":1749836025000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/prp2.282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,23]]},"references-count":96,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,2]]}},"URL":"https:\/\/doi.org\/10.1002\/prp2.282","archive":["Portico"],"relation":{},"ISSN":["2052-1707"],"issn-type":[{"value":"2052-1707","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12,23]]}}}