{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:45:08Z","timestamp":1790178308972,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T00:00:00Z","timestamp":1485820800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T00:00:00Z","timestamp":1485820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacol Res Perspect"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1002\/prp2.289","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T07:59:25Z","timestamp":1485849565000},"page":"e00289","source":"Crossref","is-referenced-by-count":10,"title":["Botulinum Neurotoxins Serotypes A and B induce paralysis of mouse striated and smooth muscles with different potencies"],"prefix":"10.1002","volume":"5","author":[{"given":"Jacquie","family":"Maignel-Ludop","sequence":"first","affiliation":[{"name":"Neurology Research; Ipsen Innovation; 5 Avenue du Canada 91940 Les Ulis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Huchet","sequence":"additional","affiliation":[{"name":"Neurology Research; Ipsen Innovation; 5 Avenue du Canada 91940 Les Ulis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Krupp","sequence":"additional","affiliation":[{"name":"Neurology Research; Ipsen Innovation; 5 Avenue du Canada 91940 Les Ulis France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,31]]},"reference":[{"key":"10.1002\/prp2.289-BIB0001|prp2289-cit-0001","unstructured":"Bahadory F Mansfield KJ Moore KH Burcher E Liu L 2014 Gene expression of Onabotulinum Toxin A Target Proteins in Porcine Bladder: Possible Effect on Substance P Release? http:\/\/www.ics.org\/Abstracts\/Publish\/218\/000290.pdf"},{"key":"10.1002\/prp2.289-BIB0002|prp2289-cit-0002","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1046\/j.1523-1747.2003.12620.x","article-title":"Botulinum toxin type B blocks sudomotor function effectively: a 6\u00a0month follow up","volume":"121","author":"Birklein","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1002\/prp2.289-BIB0003|prp2289-cit-0003","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1016\/j.eururo.2009.12.022","article-title":"Distribution of the high-affinity binding site and intracellular target of botulinum toxin type A in the human bladder","volume":"57","author":"Coelho","year":"2010","journal-title":"Eur Urol"},{"issue":"Suppl 3","key":"10.1002\/prp2.289-BIB0004|prp2289-cit-0004","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1002\/nau.22634","article-title":"Chapter 3: molecular basis for the therapeutic effectiveness of botulinum neurotoxin type A","volume":"33","author":"Dolly","year":"2014","journal-title":"Neurourol Urodyn"},{"key":"10.1002\/prp2.289-BIB0005|prp2289-cit-0005","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1113\/jphysiol.1987.sp016546","article-title":"The effects of in\u00a0vitro application of purified botulinum neurotoxin at mouse nerve terminals","volume":"386","author":"Dolly","year":"1987","journal-title":"J Physiol"},{"key":"10.1002\/prp2.289-BIB0006|prp2289-cit-0006","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.mib.2012.05.012","article-title":"Clinical applications of botulinum toxins","volume":"15","author":"Dressler","year":"2012","journal-title":"Curr Opin Microbiol"},{"key":"10.1002\/prp2.289-BIB0007|prp2289-cit-0007","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF03033929","article-title":"Clinical use of non-A botulinum toxins: botulinum toxin type B","volume":"9","author":"Dressler","year":"2006","journal-title":"Neurotox Res"},{"issue":"Suppl 1","key":"10.1002\/prp2.289-BIB0008|prp2289-cit-0008","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1468-1331.2006.01439.x","article-title":"Immunological aspects of Botox. Dysport and Myobloc\/NeuroBloc","volume":"13","author":"Dressler","year":"2006","journal-title":"Eur J Neurol"},{"key":"10.1002\/prp2.289-BIB0009|prp2289-cit-0009","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nrn2401","article-title":"The neural control of micturition","volume":"9","author":"Fowler","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"10.1002\/prp2.289-BIB0010|prp2289-cit-0010","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1111\/j.1464-410X.2009.08619.x","article-title":"Lack of effectiveness of botulinum neurotoxin A on isolated detrusor strips and whole bladders from mice and guinea pigs in\u00a0vitro","volume":"104","author":"Howles","year":"2009","journal-title":"BJU Int"},{"key":"10.1002\/prp2.289-BIB0011|prp2289-cit-0011","doi-asserted-by":"publisher","first-page":"e1003369","DOI":"10.1371\/journal.ppat.1003369","article-title":"Identification of fibroblast growth factor 3 (FGFR3) as a protein receptor for botulinum neurotoxin serotype A (BoNT\/A)","volume":"9","author":"Jacky","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1002\/prp2.289-BIB0012|prp2289-cit-0012","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0960-8966(96)00041-7","article-title":"Nerve terminal sprouting in botulinum type-A treated mouse levator auris longus muscle","volume":"6","author":"Juzans","year":"1996","journal-title":"Neuromusc Disord"},{"key":"10.1002\/prp2.289-BIB0013|prp2289-cit-0013","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.pbiomolbio.2015.02.004","article-title":"Diverse binding modes, same goal: the receptor recognition mechanism of botulinum neurotoxin","volume":"117","author":"Lam","year":"2015","journal-title":"Prog Biophys Mol Biol"},{"key":"10.1002\/prp2.289-BIB0014|prp2289-cit-0014","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1124\/jpet.110.169342","article-title":"Excitatory cholinergic and purinergic signaling in bladder are equally susceptible to botulinum neurotoxin A consistent with co-release of transmitters from efferent fibers","volume":"334","author":"Lawrence","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1002\/prp2.289-BIB0015|prp2289-cit-0015","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/0306-4522(94)90528-2","article-title":"Synaptotagmin I is present mainly in autonomic and sensory neurons of the rat peripheral nervous system","volume":"63","author":"Li","year":"1994","journal-title":"Neuroscience"},{"key":"10.1002\/prp2.289-BIB0016|prp2289-cit-0016","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/0306-4522(82)90056-2","article-title":"The effects of purified botulinum neurotoxin type A on cholinergic, adrenergic and non-adrenergic, atropine-resistant autonomic neuromuscular transmission","volume":"7","author":"MacKenzie","year":"1982","journal-title":"Neuroscience"},{"key":"10.1002\/prp2.289-BIB0017|prp2289-cit-0017","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0014-5793(95)01471-3","article-title":"The high-affinity binding of Clostridium botulinum type B neurotoxin to synaptotagmin II associated with gangliosides GTlb\/GDla","volume":"378","author":"Nishiki","year":"1996","journal-title":"FEBS Lett"},{"key":"10.1002\/prp2.289-BIB0018|prp2289-cit-0018","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.ejphar.2012.06.036","article-title":"Fenoterol functionally activates the \u03b23-adrenoceptor in human urinary bladder, comparison with rat and mouse: implications for drug discovery","volume":"690","author":"Palea","year":"2012","journal-title":"Eur J Pharmacol"},{"key":"10.1002\/prp2.289-BIB0019|prp2289-cit-0019","doi-asserted-by":"crossref","first-page":"13493","DOI":"10.1523\/JNEUROSCI.3519-06.2006","article-title":"Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses","volume":"26","author":"Pang","year":"2006","journal-title":"J Neurosci"},{"key":"10.1002\/prp2.289-BIB0020|prp2289-cit-0020","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/978-3-642-16499-6_2","article-title":"Animal models in overactive bladder research","volume":"202","author":"Parsons","year":"2011","journal-title":"Handb Exp Pharmacol"},{"key":"10.1002\/prp2.289-BIB0021|prp2289-cit-0021","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.1242\/jcs.103564","article-title":"Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins","volume":"125","author":"Peng","year":"2012","journal-title":"J Cell Sci"},{"key":"10.1002\/prp2.289-BIB0022|prp2289-cit-0022","doi-asserted-by":"publisher","first-page":"e1004177","DOI":"10.1371\/journal.ppat.1004177","article-title":"Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins","volume":"10","author":"Peng","year":"2014","journal-title":"PLoS Pathog"},{"key":"10.1002\/prp2.289-BIB0023|prp2289-cit-0023","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1016\/j.toxicon.2011.04.003","article-title":"Phrenic nerve-hemidiaphragm as a highly sensitive replacement assay for determination of functional botulinum toxin antibodies","volume":"57","author":"Rasetti-Escargueil","year":"2011","journal-title":"Toxicon"},{"key":"10.1002\/prp2.289-BIB0024|prp2289-cit-0024","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/nrmicro3295","article-title":"Botulinum neurotoxins: genetic, structural and mechanistic insights","volume":"12","author":"Rossetto","year":"2014","journal-title":"Nat Rev Microbiol"},{"key":"10.1002\/prp2.289-BIB0025|prp2289-cit-0025","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/978-3-642-33570-9_4","article-title":"Double receptor anchorage of botulinum neurotoxins accounts for their exquisite neurospecificity","volume":"364","author":"Rummel","year":"2013","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1002\/prp2.289-BIB0026|prp2289-cit-0026","doi-asserted-by":"publisher","first-page":"1942","DOI":"10.1111\/j.1471-4159.2009.06298.x","article-title":"Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilizing three isoforms of SV2 as second receptor","volume":"110","author":"Rummel","year":"2009","journal-title":"J Neurochem"},{"key":"10.1002\/prp2.289-BIB0027|prp2289-cit-0027","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/359832a0","article-title":"Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin","volume":"359","author":"Schiavo","year":"1992","journal-title":"Nature"},{"key":"10.1002\/prp2.289-BIB0028|prp2289-cit-0028","first-page":"734","article-title":"Botulinum toxin injection of eye muscles to correct strabismus","volume":"79","author":"Scott","year":"1981","journal-title":"Trans Am Ophtalmol Soc"},{"key":"10.1002\/prp2.289-BIB0029|prp2289-cit-0029","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0028-3908(67)90048-2","article-title":"Actions of calcium and magnesium on the rate of onset of botulinum toxin paralysis of the rat diaphragm","volume":"6","author":"Simpson","year":"1967","journal-title":"Int J Neuropharmacol"},{"key":"10.1002\/prp2.289-BIB0030|prp2289-cit-0030","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0361-9230(03)00114-X","article-title":"Effect of stimulation intensity and botulinum toxin isoform on rat bladder strip contractions","volume":"61","author":"Smith","year":"2003","journal-title":"Brain Res Bull"},{"key":"10.1002\/prp2.289-BIB0031|prp2289-cit-0031","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.febslet.2011.12.037","article-title":"Human synaptotagmin-II is not a high affinity receptor for botulinum neurotoxin B and G: increased therapeutic dosage and immunogenicity","volume":"586","author":"Strotmeier","year":"2012","journal-title":"FEBS Lett"},{"key":"10.1002\/prp2.289-BIB0032|prp2289-cit-0032","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1016\/j.juro.2012.07.001","article-title":"Differential effects of botulinum neurotoxin A on bladder contractile responses to activation of efferent nerves, smooth muscles and afferent nerves in rats","volume":"188","author":"Takahashi","year":"2012","journal-title":"J Urol"},{"key":"10.1002\/prp2.289-BIB0033|prp2289-cit-0033","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/1471-2490-14-37","article-title":"Development of an in\u00a0vitro model to measure bioactivity of botulinum neurotoxin A in rat bladder muscle strips","volume":"14","author":"Uhm","year":"2014","journal-title":"BMC Urol"},{"key":"10.1002\/prp2.289-BIB0034|prp2289-cit-0034","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1042\/BJ20120100","article-title":"Longer-acting and highly potent chimeric inhibitors of excessive exocytosis created with domains from botulinum neurotoxin A and B","volume":"444","author":"Wang","year":"2012","journal-title":"Biochem J"},{"key":"10.1002\/prp2.289-BIB0035|prp2289-cit-0035","doi-asserted-by":"publisher","first-page":"5035","DOI":"10.3390\/toxins7124861","article-title":"Generation and characterization of six recombinant botulinum neurotoxins as reference material to serve in an international proficiency test","volume":"7","author":"Weisemann","year":"2015","journal-title":"Toxins (Basel)"}],"container-title":["Pharmacology Research &amp; Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fprp2.289","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/prp2.289","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T01:00:37Z","timestamp":1625446837000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/prp2.289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,31]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,2]]}},"URL":"https:\/\/doi.org\/10.1002\/prp2.289","archive":["Portico"],"relation":{},"ISSN":["2052-1707"],"issn-type":[{"value":"2052-1707","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1,31]]}}}