{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:13:53Z","timestamp":1790716433143,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,15]],"date-time":"2017-12-15T00:00:00Z","timestamp":1513296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["13273147"],"award-info":[{"award-number":["13273147"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Paracetamol has recently been suggested to affect emotion processing in addition to alleviating pain in humans. We investigated in adult male Hannover\u2013Wistar rats whether acute intraperitoneally administrated paracetamol affects behavior in tests measuring anxiety, mood, motor activity, and memory. Unoperated rats received saline or a low (50\u00a0mg\/kg) or high (300\u00a0mg\/kg) dose of paracetamol, while rats with a spared nerve injury (<jats:styled-content style=\"fixed-case\">SNI<\/jats:styled-content>) model of neuropathy and sham\u2010operated rats received saline or the low dose of paracetamol. Rats were tested on open\u2010field (<jats:styled-content style=\"fixed-case\">OFT<\/jats:styled-content>), elevated plus\u2010maze (<jats:styled-content style=\"fixed-case\">EPM<\/jats:styled-content>), light\u2010dark box (<jats:styled-content style=\"fixed-case\">LDB<\/jats:styled-content>), novel\u2010object recognition (<jats:styled-content style=\"fixed-case\">NOR<\/jats:styled-content>), sucrose preference, rotarod, and monofilament tests. In unoperated rats, both the low and high dose of paracetamol reduced line crossings, and grooming time in the<jats:styled-content style=\"fixed-case\">OFT<\/jats:styled-content>, and novel preference in<jats:styled-content style=\"fixed-case\">NOR<\/jats:styled-content>. The high dose of paracetamol increased the time spent in the closed arm in<jats:styled-content style=\"fixed-case\">EPM<\/jats:styled-content>, reduced the number of rearings and leanings in<jats:styled-content style=\"fixed-case\">OFT<\/jats:styled-content>, the time spent in the light box in<jats:styled-content style=\"fixed-case\">LDB<\/jats:styled-content>, and sucrose preference. Paracetamol had no significant effect on the rotarod test measuring motor activity. The low dose of paracetamol suppressed mechanical pain hypersensitivity in<jats:styled-content style=\"fixed-case\">SNI<\/jats:styled-content>rats, without influencing pain behavior in sham\u2010operated rats. Saline\u2010 but not paracetamol\u2010treated<jats:styled-content style=\"fixed-case\">SNI<\/jats:styled-content>rats spent more time than sham\u2010operated rats in the closed arm in the<jats:styled-content style=\"fixed-case\">EPM<\/jats:styled-content>test. Together the results suggest that a high dose of paracetamol increases anxiety\u2010like and anhedonic behavior, and impairs recognition memory in unoperated controls, while in neuropathy, a low dose of paracetamol reduces nerve injury\u2010associated anxiety probably by reducing neuropathic pain.<\/jats:p>","DOI":"10.1002\/prp2.367","type":"journal-article","created":{"date-parts":[[2017,12,15]],"date-time":"2017-12-15T23:26:27Z","timestamp":1513380387000},"source":"Crossref","is-referenced-by-count":33,"title":["Anxiety\u2010 and activity\u2010related effects of paracetamol on healthy and neuropathic rats"],"prefix":"10.1002","volume":"6","author":[{"given":"Zuyue","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Physiology Faculty of Medicine University of Helsinki Helsinki Finland"},{"name":"Department of Neuroscience and Biomedical Engineering AMI Centre Aalto University School of Science Espoo Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Medicine University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Pertovaara","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Medicine University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Kunming Primates Research Center Kunming Institute of Zoology Chinese Academy of Sciences Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1462-7560","authenticated-orcid":false,"given":"Synn\u00f6ve","family":"Carlson","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Medicine University of Helsinki Helsinki Finland"},{"name":"Department of Neuroscience and Biomedical Engineering AMI Centre Aalto University School of Science Espoo Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.02.020"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956797610374741"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195096736.001.0001","volume-title":"Affective Neuroscience: The Foundations of Human and Animal Emotions","author":"Panksepp J","year":"1998"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956797612464786"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jesp.2014.09.006","article-title":"Can acetaminophen reduce the pain of decision\u2010making?","volume":"56","author":"DeWall CN","year":"2015","journal-title":"J Exp Soc Psychol"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsw057"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.09.009"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.12.015"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1559"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-008-0284-9"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00276-1"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.02.024"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kjms.2011.11.003"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2016.09.007"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0071444"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(91)90817-A"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(98)00230-9"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(90)90172-3"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00504983"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjpain.2015.09.008"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.205"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2004.03.012"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.08.001.2009"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-303-9_1"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(03)01274-3"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2009.12.036"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199819060-00001"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2009.06.020"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e3283566065"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2016.03.010"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2015.04.014"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M501489200"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2005.12.002"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002100100484"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2012.12.052"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.07.012"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.05.068"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.05.003"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2003.12.028"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.04.043"}],"container-title":["Pharmacology Research &amp; Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fprp2.367","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prp2.367","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T22:02:23Z","timestamp":1751148143000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/prp2.367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,15]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1002\/prp2.367"],"URL":"https:\/\/doi.org\/10.1002\/prp2.367","archive":["Portico"],"relation":{},"ISSN":["2052-1707","2052-1707"],"issn-type":[{"value":"2052-1707","type":"print"},{"value":"2052-1707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,15]]},"article-number":"e00367"}}