{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:18:47Z","timestamp":1762899527358,"version":"3.41.2"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T00:00:00Z","timestamp":1519257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["T32"],"award-info":[{"award-number":["T32"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01 RX000194"],"award-info":[{"award-number":["I01 RX000194"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) infection is a major cause of chronic liver disease. <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> cure has been linked to improved patient outcomes. In the era of direct\u2010acting antivirals (<jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content>s), <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> cure has become the goal, as defined by sustained virological response 12\u00a0weeks (<jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>12) after completion of therapy. Historically, African\u2010Americans have had lower <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>12 rates compared to White people in the interferon era, which had been attributed to the high prevalence of non\u2010<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> interleukin 28B (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>28B) type. Less is known about the association between race\/ethnicity and <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>12 in <jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content>\u2010treated era. The aim of the study is to evaluate the predictors of <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>12 in a diverse, single\u2010center Veterans Affairs population. We conducted a retrospective study of patients undergoing <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> therapy with <jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content>s from 2014 to 2016 at the <jats:styled-content style=\"fixed-case\">VA<\/jats:styled-content> Greater Los Angeles Healthcare System. We performed a multivariable logistic regression analysis to determine predictors of <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>12, adjusting for age, <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> genotype, <jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content> regimen and duration, human immunodeficiency virus (<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>) status, fibrosis, nonalcoholic fatty liver disease (<jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>) fibrosis score, homelessness, mental health, and adherence. Our cohort included 1068 patients, out of which 401 (37.5%) were White people and 400 (37.5%) were African\u2010American. Genotype 1 was the most common genotype (83.9%, N\u00a0=\u00a0896). In the adjusted models, race\/ethnicity and the\u00a0presence of fibrosis were statistically significant predictors of non\u2010<jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>. African\u2010Americans had 57% lower odds for reaching <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>12 (adj.<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.43, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.5\u20104.1) compared to White people. Advanced fibrosis (adj.<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.40, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a00.26\u20100.68) was also a significant predictor of non\u2010<jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>. In a single\u2010center <jats:styled-content style=\"fixed-case\">VA<\/jats:styled-content> population on <jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content>s, African\u2010Americans were less likely than White people to reach <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>12 when adjusting for covariates.<\/jats:p>","DOI":"10.1002\/prp2.379","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T04:49:14Z","timestamp":1519361354000},"source":"Crossref","is-referenced-by-count":21,"title":["Race affects <scp>SVR<\/scp>12 in a large and ethnically diverse hepatitis C\u2010infected patient population following treatment with direct\u2010acting antivirals: Analysis of a single\u2010center Department of Veterans Affairs cohort"],"prefix":"10.1002","volume":"6","author":[{"given":"Jihane N.","family":"Benhammou","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Parenteral Nutrition Department of Medicine David Geffen School of Medicine at UCLA Los Angeles CA USA"},{"name":"Vatche &amp; Tamar Manoukian Division of Digestive Diseases Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tien S.","family":"Dong","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Parenteral Nutrition Department of Medicine David Geffen School of Medicine at UCLA Los Angeles CA USA"},{"name":"Vatche &amp; Tamar Manoukian Division of Digestive Diseases Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Folasade P.","family":"May","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Parenteral Nutrition Department of Medicine David Geffen School of Medicine at UCLA Los Angeles CA USA"},{"name":"Vatche &amp; Tamar Manoukian Division of Digestive Diseases Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenna","family":"Kawamoto","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Parenteral Nutrition Department of Medicine David Geffen School of Medicine at UCLA Los Angeles CA USA"},{"name":"Division of Infectious Diseases VA Greater Los Angeles Healthcare System Department of Medicine David Geffen School of Medicine at UCLA Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram","family":"Dixit","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Parenteral Nutrition Department of Medicine David Geffen School of Medicine at UCLA Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Jackson","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Parenteral Nutrition Department of Medicine David Geffen School of Medicine at UCLA Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek","family":"Dixit","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Parenteral Nutrition Department of Medicine David Geffen School of Medicine at UCLA Los Angeles CA USA"},{"name":"Vatche &amp; 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