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In the present investigation, the effect of <jats:styled-content style=\"fixed-case\">THC<\/jats:styled-content> on renal and cardiovascular outcomes was studied in rats with chronic kidney disease (<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> rats were randomized following 5\/6 nephrectomy to a special diet for 9\u00a0weeks which contained 1% <jats:styled-content style=\"fixed-case\">THC<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">THC<\/jats:styled-content> group). Low\u2010dose polyenylphosphatidylcholine was used as a lipid carrier to increase bioavailability. Endpoints included tail blood pressure, normalized heart weight, plasma and urine biochemical data, and kidney tissue analyses. <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> animals demonstrated increased proteinuria, decreased creatinine clearance, hypertension, and cardiac hypertrophy. The antioxidant proteins CuZn <jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content> and glutathione peroxidase were decreased in the remnant kidney, while apoptosis (caspase\u20103) and fibrosis (alpha\u2010<jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content> actin) were increased. Renal fibrosis was confirmed histologically on trichrome staining. These pathologic changes were ameliorated in the <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">THC<\/jats:styled-content> group with significant decrease in proteinuria, hypertension, and kidney fibrosis. <jats:styled-content style=\"fixed-case\">THC<\/jats:styled-content> therapy restored levels of CuZn <jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content> and glutathione peroxidase. Consistent with prior reports, dietary <jats:styled-content style=\"fixed-case\">THC<\/jats:styled-content> did not improve nuclear Nrf2 levels. In summary, dietary <jats:styled-content style=\"fixed-case\">THC<\/jats:styled-content> therapy improved expression of antioxidant proteins in the remnant kidney, decreased renal fibrosis and proteinuria, and ameliorated hypertension in 5\/6 nephrectomized rats.<\/jats:p>","DOI":"10.1002\/prp2.385","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T19:40:39Z","timestamp":1519414839000},"source":"Crossref","is-referenced-by-count":23,"title":["Dietary tetrahydrocurcumin reduces renal fibrosis and cardiac hypertrophy in 5\/6 nephrectomized rats"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3118-1073","authenticated-orcid":false,"given":"Wei Ling","family":"Lau","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension Department of Medicine University of California\u2010Irvine Orange 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