{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:14:43Z","timestamp":1790673283967,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ajulemic acid (AJA, CT\u20103, IP\u2010751, JBT\u2010101, anabasum) is a first\u2010in\u2010class, synthetic, orally active, cannabinoid\u2010derived drug that preferentially binds to the CB2 receptor and is nonpsychoactive. In preclinical studies, and in Phase 1 and 2 clinical trials, AJA showed a favorable safety, tolerability, and pharmacokinetic profile. It also demonstrated significant efficacy in preclinical models of inflammation and fibrosis. It suppresses tissue scarring and stimulates endogenous eicosanoids that resolve chronic inflammation and fibrosis without causing immunosuppression. AJA is currently being developed for use in 4 separate but related indications including systemic sclerosis (SSc), cystic fibrosis, dermatomyositis (DM), and systemic lupus erythematosus. Phase 2 clinical trials in the first 3 targets demonstrated that it is safe, is a potential treatment for these orphan diseases and appears to be a potent inflammation\u2010resolving drug with a unique mechanism of action, distinct from the nonsteroidal anti\u2010inflammatory drug (NSAID), and will be useful for treating a wide range of chronic inflammatory diseases. It may be considered to be a disease\u2010modifying drug unlike most NSAIDs that only provide symptomatic relief. AJA is currently being evaluated in 24\u2010month open\u2010label extension studies in SSc and in skin\u2010predominant DM. A Phase 3 multicenter trial to demonstrate safety and efficacy in SSc has recently been initiated.<\/jats:p>","DOI":"10.1002\/prp2.394","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T06:39:47Z","timestamp":1523342387000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Ajulemic acid: potential treatment for chronic inflammation"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9864-3335","authenticated-orcid":false,"given":"Sumner H.","family":"Burstein","sequence":"first","affiliation":[{"name":"Department of Biochemistry &amp; Molecular Pharmacology University of Massachusetts Medical School Worcester MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2014.03.038"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201600646R"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199801)41:1<163::AID-ART20>3.0.CO;2-9"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6616(03)00064-0"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21263"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-239442"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200314"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-016-0373-0"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(01)00700-6"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05882.x"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-006-9004-4"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(02)01604-0"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32247-X"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21046"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00755599"},{"key":"e_1_2_13_17_1","volume-title":"Cystic Fibrosis Foundation Research Conference: Pushing the Frontiers","author":"Bonfield TL","year":"2015"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.17"},{"key":"e_1_2_13_19_1","doi-asserted-by":"crossref","first-page":"S01.05","DOI":"10.1016\/S1569-1993(17)30160-1","article-title":"A Phase 2 study of the safety, pharmacokinetics, and efficacy of anabasum (JBT\u2010101) in cystic fibrosis (CF)","volume":"16","author":"Chmiel JF","year":"2017","journal-title":"J Cyst Fibros"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199503303321303"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105185"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0170OC"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.05.035"},{"key":"e_1_2_13_24_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0022-3565(24)35067-0","article-title":"1\u2032,1\u2032\u2010Dimethylheptyl\u2010delta\u20108\u2010tetrahydrocannabinol\u201011\u2010oic acid: a novel, orally effective cannabinoid with analgesic and anti\u2010inflammatory properties","volume":"291","author":"Dajani EZ","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1208\/aapsj070115"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm4005626"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.03.037"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2008.09.004"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2009.12.013"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-118323"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13479"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjp2.43"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2014.04.062"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm970126f"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.110.003004"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00095a007"}],"container-title":["Pharmacology Research &amp; Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fprp2.394","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prp2.394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T15:02:35Z","timestamp":1751554955000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/prp2.394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1002\/prp2.394"],"URL":"https:\/\/doi.org\/10.1002\/prp2.394","archive":["Portico"],"relation":{},"ISSN":["2052-1707","2052-1707"],"issn-type":[{"value":"2052-1707","type":"print"},{"value":"2052-1707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"2018-01-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00394"}}