{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T15:17:18Z","timestamp":1789917438982,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T00:00:00Z","timestamp":1541548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To evaluate the onset timing of musculoskeletal adverse events (\n                    <jats:styled-content style=\"fixed-case\">MAE<\/jats:styled-content>\n                    s) that develop during statin monotherapy and to determine whether concomitant drugs used concurrently with statin therapy shifts the onset timing of\n                    <jats:styled-content style=\"fixed-case\">MAE<\/jats:styled-content>\n                    s. Cases in which statins (atorvastatin, rosuvastatin, simvastatin, lovastatin, fluvastatin, pitavastatin, and pravastatin) were prescribed were extracted from the\n                    <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>\n                    Food and Drug Administration (\n                    <jats:styled-content style=\"fixed-case\">FDA<\/jats:styled-content>\n                    ) Adverse Event Reporting System (\n                    <jats:styled-content style=\"fixed-case\">FAERS<\/jats:styled-content>\n                    ) Data Files. The onset timing of\n                    <jats:styled-content style=\"fixed-case\">MAE<\/jats:styled-content>\n                    s during statin monotherapy was evaluated by determining the difference between statin start date and\n                    <jats:styled-content style=\"fixed-case\">MAE<\/jats:styled-content>\n                    onset date. The use of concomitant drugs with statin therapy was included in the analysis. Statins used in combination with concomitant drugs were compared with statin monotherapy to determine if the use of concomitant drugs shifted the onset timing of\n                    <jats:styled-content style=\"fixed-case\">MAE<\/jats:styled-content>\n                    s. The onset of\n                    <jats:styled-content style=\"fixed-case\">MAE<\/jats:styled-content>\n                    s was significantly faster with atorvastatin and rosuvastatin than with simvastatin. A difference in onset timing was not detected with other statins because the number of cases was too small for analysis. When evaluating concomitant drug use, the concomitant drugs that shifted the onset timing of\n                    <jats:styled-content style=\"fixed-case\">MAE<\/jats:styled-content>\n                    s could not be detected. Statins with strong low\u2010density lipoprotein cholesterol\u2010lowering effects (atorvastatin and rosuvastatin) contributed not only to a high risk of\n                    <jats:styled-content style=\"fixed-case\">MAE<\/jats:styled-content>\n                    onset, but also to a shorter time\u2010to\u2010onset. No concomitant drug significantly shifted the onset timing of\n                    <jats:styled-content style=\"fixed-case\">MAE<\/jats:styled-content>\n                    s when used concurrently with statins.\n                  <\/jats:p>","DOI":"10.1002\/prp2.439","type":"journal-article","created":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T03:14:26Z","timestamp":1541560466000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Onset timing of statin\u2010induced musculoskeletal adverse events and concomitant drug\u2010associated shift in onset timing of\n                    <scp>MAE<\/scp>\n                    s"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5397-0137","authenticated-orcid":false,"given":"Hayato","family":"Akimoto","sequence":"first","affiliation":[{"name":"Department of Analytical Pharmaceutics and Informatics Faculty of Pharmacy and Pharmaceutical 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