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Effective vasodilator therapy of the pulmonary hypertension is highly needed. Therefore, we investigated the effects of a newly developed effective pulmonary vasodilator, the organic mononitrites of 1,2\u2010propanediol (PDNO), in a rabbit model of acute pulmonary embolism. In anesthetized and ventilated rabbits, systemic and pulmonary hemodynamics, exhaled nitric oxide (NO), plasma nitrite concentration, and blood gases were monitored. First, dose\u2013response experiments with intravenous and left heart ventricle infusions of PDNO and inorganic nitrite were done in naive animals and in pulmonary hypertension induced by a thromboxane A<jats:sub>2<\/jats:sub> analogue. Second, acute pulmonary embolism was induced and either PDNO or placebo were administered intravenously within 20\u00a0minutes and evaluated within 1\u00a0hour after pulmonary embolization. PDNO intravenously, in contrast to inorganic nitrite intravenously, increased exhaled NO and counteracted pulmonary hypertension and vasodilated the systemic circulation, dose\u2010dependently, thereby showing efficient NO donation. Pulmonary embolization induced pulmonary hypertension and gas exchange disturbances. PDNO significantly decreased and normalized pulmonary vascular resistance and the right ventricle rate\u2010pressure product, without causing tolerance, with no significant side effects on the systemic circulation, nor on blood\u2010gas values or on methemoglobin formation. In conclusion, PDNO is a NO donor and an efficient vasodilator in the pulmonary circulation. Treatment with this or similar organic nitrites intravenously may be a future option to avoid right heart failure in life\u2010threatening acute pulmonary embolism.<\/jats:p>","DOI":"10.1002\/prp2.462","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T10:34:28Z","timestamp":1548326068000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Treatment with new organic nitrites in pulmonary hypertension of acute experimental pulmonary embolism"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8461-5074","authenticated-orcid":false,"given":"Kristofer F.","family":"Nilsson","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology Karolinska Institute Stockholm Sweden"},{"name":"Department of Cardiothoracic and Vascular Surgery Faculty of Medicine and Health \u00d6rebro University \u00d6rebro 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