{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T11:57:12Z","timestamp":1759838232174,"version":"3.41.2"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T00:00:00Z","timestamp":1565740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["240197\/H10."],"award-info":[{"award-number":["240197\/H10."]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["PRVOUK-P03\/LF1\/9"],"award-info":[{"award-number":["PRVOUK-P03\/LF1\/9"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","award":["16-28157A","LF1","9"],"award-info":[{"award-number":["16-28157A","LF1","9"]}],"id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["240197","H10"],"award-info":[{"award-number":["240197","H10"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is lack of knowledge about the safety of treatment with methadone and buprenorphine as part of opioid maintenance treatment (OMT) during pregnancy. The purpose of this study was to examine neonatal outcomes concerning the use of OMT during pregnancy. We used nationwide registry linkages from the Czech Republic (2000\u20102014) and Norway (2004\u20102013). We compared prenatally OMT\u2013exposed newborns with (a) newborns of women hospitalized with opioid use disorder during pregnancy in the Czech sample and (b) newborns with neonatal abstinence syndrome (NAS) in Norway. We performed multivariate linear and binary logistic regression exploring the associations between OMT and neonatal outcomes (growth parameters, gestational age, fetal death, small for gestational age, Apgar score, and NAS). Regression coefficients (<jats:italic>b<\/jats:italic>) and odds ratios (ORs) were estimated. The cohorts consisted of 333 Czech, and 235 Norwegian OMT\u2013exposed newborns, and 106 and 294 newborns in the comparison groups, respectively. In both countries, the neonatal growth parameters were similar in the OMT and the comparison groups. In Norway, OMT exposure prolonged gestational age (adjusted <jats:italic>b<\/jats:italic>\u00a0=\u00a00.96\u00a0weeks, 95% confidence interval [CI] =0.39\u20101.53) while the odds of preterm birth and Apgar score at 5\u00a0minutes were lower than in the comparison group (adjusted OR\u00a0=\u00a00.35, 0.16\u20100.75 and aOR\u00a0=\u00a00.21, 0.06\u20100.78, respectively). Newborns of women in OMT had similar growth parameters as newborns of women with opioid use disorders who were not in OMT during pregnancy. Overall, our findings do not suggest that OMT results in worse neonatal outcomes.<\/jats:p>","DOI":"10.1002\/prp2.501","type":"journal-article","created":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T06:18:40Z","timestamp":1565849920000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prenatal exposure to opioid maintenance treatment and neonatal outcomes: Nationwide registry studies from the Czech Republic and Norway"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1773-0184","authenticated-orcid":false,"given":"Marte","family":"Handal","sequence":"first","affiliation":[{"name":"Department of Mental Disorders Norwegian Institute of Public Health Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanka","family":"Nechansk\u00e1","sequence":"additional","affiliation":[{"name":"Department of Addictology, First Faculty of Medicine Charles University Prague Czech Republic"},{"name":"Institute of Health Information and Statistics of the Czech Republic Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Skurtveit","sequence":"additional","affiliation":[{"name":"Department of Mental Disorders Norwegian Institute of Public Health Oslo Norway"},{"name":"Norwegian Centre for Addiction Research at the University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingunn Olea","family":"Lund","sequence":"additional","affiliation":[{"name":"Department of Mental Disorders Norwegian Institute of Public Health Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Gabrhel\u00edk","sequence":"additional","affiliation":[{"name":"Department of Addictology, First Faculty of Medicine Charles University Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Engeland","sequence":"additional","affiliation":[{"name":"Department of Chronic Diseases and Ageing Norwegian Institute of Public Health Oslo Norway"},{"name":"Department of Global Public Health and Primary Care University of Bergen Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktor","family":"Mrav\u010d\u00edk","sequence":"additional","affiliation":[{"name":"Department of Addictology, First Faculty of Medicine Charles University Prague Czech Republic"},{"name":"National Monitoring Centre for Drugs and Addiction Office of the Government of the Czech Republic Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005359"},{"key":"e_1_2_8_3_1","unstructured":"WHO.Guidelines for identification and management of substance use and substance use disorders in pregnancy.2014."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8545(05)70362-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(77)90017-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.58.5.681"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197312062892303"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwu190"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.14192"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/157015908784533842"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2165\/11632820-000000000-00000"},{"key":"e_1_2_8_12_1","first-page":"5","article-title":"Birth and neonatal outcomes following opioid use in pregnancy: a danish population\u2010based study","volume":"9","author":"Norgaard M","year":"2015","journal-title":"Subst Abuse"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1891\/0730-0832.35.5.277"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2012.04.008"},{"key":"e_1_2_8_15_1","article-title":"Confounding of the comparative safety of prenatal opioid agonist","volume":"6","author":"Brogly SB","year":"2015","journal-title":"Therapy. J Addict Res Ther"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwx341"},{"key":"e_1_2_8_17_1","first-page":"21","article-title":"Overview of medicaid capitation and case\u2010management initiatives","author":"Freund DA","year":"1986","journal-title":"Health Care Financ Rev"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000222"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(02)00229-6"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1802197"},{"key":"e_1_2_8_21_1","unstructured":"Norwegian Directorate of Health.National Guidelines for Opioid Maintenance Treatment of Opioid Dependency [Only in Norwegian: Nasjonal retningslinje for legemiddelassistert rehabilitering ved opioidavhengighet]. Oslo:2010."},{"key":"e_1_2_8_22_1","first-page":"25","article-title":"Methadone substitution treatment in the Czech Republic","volume":"2","author":"Popov P","year":"2002","journal-title":"Adiktologie"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2012.04049.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.21101\/cejph.a4474"},{"key":"e_1_2_8_25_1","unstructured":".WHO Collaborating Centre for Drug Statistics Methodology.ATC Classification Index with DDDs 2013;2013."},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb14164.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780120902"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/cch.12320"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2015-309584"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.21128"},{"key":"e_1_2_8_31_1","unstructured":"Mrav\u010d\u00edkV Chomynov\u00e1P Grohmannov\u00e1K Jan\u00edkov\u00e1B Tion Le\u0161tinov\u00e1Z RousZ.V\u00fdro\u010dn\u00ed zpr\u00e1va o stavu ve v\u011bcech drog v \u010cesk\u00e9 republice v roce 2015 (only in Czech; Annual Report on Drug Situation 2015 \u2010 the Czech Republic). In: republiky \u00dav\u010c editor. Praha; 2016."},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2018.00033"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/10550490802266276"},{"key":"e_1_2_8_34_1","first-page":"CD002209","article-title":"Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence","author":"Mattick RP","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2008.02283.x"}],"container-title":["Pharmacology Research &amp; Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prp2.501","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/prp2.501","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prp2.501","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T12:41:35Z","timestamp":1694263295000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/prp2.501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,14]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1002\/prp2.501"],"URL":"https:\/\/doi.org\/10.1002\/prp2.501","archive":["Portico"],"relation":{},"ISSN":["2052-1707","2052-1707"],"issn-type":[{"type":"print","value":"2052-1707"},{"type":"electronic","value":"2052-1707"}],"subject":[],"published":{"date-parts":[[2019,8,14]]},"assertion":[{"value":"2019-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00501"}}