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However, the severe adverse effects associated generate the need for its therapeutic optimization. Conversely, though histamine is undoubtedly related to asthma development, there is a lack of efficacy of antihistamines in controlling its symptoms, which prevents their clinical application. We have reported that antihistamines potentiate glucocorticoids\u2019 responses in vitro and recent observations have indicated that the coadministration of an antihistamine and a synthetic glucocorticoid has synergistic effects on a murine model of allergic rhinitis. Here, the aim of this work is to establish if this therapeutic combination could be beneficial in a murine model of asthma. We used an allergen\u2010induced model of asthma (employing ovalbumin) to evaluate the effects of the synthetic glucocorticoid dexamethasone combined with the antihistamine azelastine. Our results indicate that the cotreatment with azelastine and a suboptimal dose of dexamethasone can improve allergic lung inflammation as shown by a decrease in eosinophils in bronchoalveolar lavage, fewer peribronchial and perivascular infiltrates, and mucin\u2010producing cells. In addition, serum levels of allergen\u2010specific IgE and IgG1 were also reduced, as well as the expression of lung inflammatory\u2010related genes IL\u20104, IL\u20105, Muc5AC, and Arginase I. The potentiation of dexamethasone effects by azelastine could allow to reduce the effective glucocorticoid dose needed to achieve a therapeutic effect. These findings provide first new insights into the potential benefits of glucocorticoids and antihistamines combination for the treatment of asthma and grants further research to evaluate this approach in other related inflammatory conditions.<\/jats:p>","DOI":"10.1002\/prp2.531","type":"journal-article","created":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T16:20:48Z","timestamp":1572366048000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Azelastine potentiates antiasthmatic dexamethasone effect on a murine asthma model"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3844-577X","authenticated-orcid":false,"given":"Carlos D.","family":"Zappia","sequence":"first","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica Universidad de Buenos Aires Buenos Aires Argentina"},{"name":"Instituto de Investigaciones Farmacol\u00f3gicas (ININFA) CONICET \u2013 Universidad de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariadna","family":"Soto","sequence":"additional","affiliation":[{"name":"Centro de Estudios en Salud y Medio Ambiente (CESyMA) Escuela de Ciencia y Tecnolog\u00eda Universidad Nacional de San Mart\u00edn \u2013 CONICET Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Granja\u2010Galeano","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica Universidad de Buenos Aires Buenos Aires Argentina"},{"name":"Instituto de Investigaciones Farmacol\u00f3gicas (ININFA) CONICET \u2013 Universidad de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Fenoy","sequence":"additional","affiliation":[{"name":"Centro de Estudios en Salud y Medio Ambiente (CESyMA) Escuela de Ciencia y Tecnolog\u00eda Universidad Nacional de San Mart\u00edn \u2013 CONICET Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica Universidad de Buenos Aires Buenos Aires Argentina"},{"name":"Instituto de Investigaciones Farmacol\u00f3gicas (ININFA) CONICET \u2013 Universidad de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Davio","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica Universidad de Buenos Aires Buenos Aires Argentina"},{"name":"Instituto de Investigaciones Farmacol\u00f3gicas (ININFA) CONICET \u2013 Universidad de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Shayo","sequence":"additional","affiliation":[{"name":"Laboratorio de Patolog\u00eda y Farmacolog\u00eda Molecular Instituto de Biolog\u00eda y Medicina Experimental  CONICET Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos P.","family":"Fitzsimons","sequence":"additional","affiliation":[{"name":"Center for Neuroscience Swammerdam Institute for Life Sciences Faculty of Science University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Goldman","sequence":"additional","affiliation":[{"name":"Centro de Estudios en Salud y Medio Ambiente (CESyMA) Escuela de Ciencia y Tecnolog\u00eda Universidad Nacional de San Mart\u00edn \u2013 CONICET Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1113-4608","authenticated-orcid":false,"given":"Federico","family":"Monczor","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica Universidad de Buenos Aires Buenos Aires Argentina"},{"name":"Instituto de Investigaciones Farmacol\u00f3gicas (ININFA) CONICET \u2013 Universidad de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40733-016-0029-3"},{"key":"e_1_2_10_3_1","unstructured":"CDC.Centers for Disease Control and Prevention. 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