{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:44:27Z","timestamp":1791600267357,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T00:00:00Z","timestamp":1589500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["141206"],"award-info":[{"award-number":["141206"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Caffeine is widely used in preterm neonates suffering from apnea of prematurity (AOP), and it has become one of the most frequently prescribed medications in neonatal intensive care units. Goal of this study is to investigate how caffeine citrate treatment affects sleep\u2010wake behavior in preterm neonates. The observational study consists of 64 preterm neonates during their first 5\u00a0days of life with gestational age (GA) &lt;32\u00a0weeks or very low birthweight of\u00a0&lt;\u00a01500\u00a0g. A total of 52 patients treated with caffeine citrate and 12 patients without caffeine citrate were included. Sleep\u2010wake behavior was scored in three stages: active sleep, quiet sleep, and wakefulness. Individual caffeine concentration of every neonate was simulated with a pharmacokinetic model. In neonates with GA\u00a0\u2265\u00a028\u00a0weeks, wakefulness increased and active sleep decreased with increasing caffeine concentrations, whereas quiet sleep remained unchanged. In neonates with GA\u00a0&lt;\u00a028\u00a0weeks, no clear caffeine effects on sleep\u2010wake behavior could be demonstrated. Caffeine increases fraction of wakefulness, alertness, and most probably also arousability at cost of active but not quiet sleep in preterm neonates. As such, caffeine should therefore not affect time for physical and cerebral regeneration during sleep in preterm neonates.<\/jats:p>","DOI":"10.1002\/prp2.596","type":"journal-article","created":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T01:18:03Z","timestamp":1589591883000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Caffeine preserves quiet sleep in preterm neonates"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9386-0506","authenticated-orcid":false,"given":"Gilbert","family":"Koch","sequence":"first","affiliation":[{"name":"Pediatric Pharmacology and Pharmacometrics Research Center University Children\u2019s Hospital Basel (UKBB) Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Sch\u00f6nfeld","sequence":"additional","affiliation":[{"name":"Pediatric Pharmacology and Pharmacometrics Research Center University Children\u2019s Hospital Basel (UKBB) Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Jost","sequence":"additional","affiliation":[{"name":"Department of Neonatology University Children\u2019s Hospital Basel (UKBB) Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Pediatric Pharmacology and Pharmacometrics Research Center University Children\u2019s Hospital Basel (UKBB) Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven M.","family":"Schulzke","sequence":"additional","affiliation":[{"name":"Department of Neonatology University Children\u2019s Hospital Basel (UKBB) Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Pfister","sequence":"additional","affiliation":[{"name":"Pediatric Pharmacology and Pharmacometrics Research Center University Children\u2019s Hospital Basel (UKBB) Basel Switzerland"},{"name":"Quantitative Solutions a Certara Company Princeton NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre N.","family":"Datta","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology and Developmental Medicine University Children\u2019s Hospital Basel (UKBB) Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,15]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"WHO Preterm birth.2015. https:\/\/www.who.int\/en\/news\u2010room\/fact\u2010sheets\/detail\/preterm\u2010birth. 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