{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:52:35Z","timestamp":1786978355380,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Portuguese National Association of Pharmacies"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The aim of the study is to investigate the patterns of polypharmacy, clinical\u2010relevant drug\u2010drug interactions (DDIs), and potentially inappropriate medicines (PIMs), and whether polypharmacy, potential serious clinically\u2010relevant DDIs, or PIMs can be associated with low quality of life (QoL) index scores of older adults with type 2 diabetes (T2D). A cross\u2010sectional study was conducted using data of 670 elderly T2D sub\u2010cohort from a nationwide pharmacy\u2010based intensive monitoring study of inception cohort of T2D in Portugal. 72.09% were found on polypharmacy (\u22655 medicines). Participants on polypharmacy were mostly females (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.0115); more obese (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.0131); have more comorbid conditions (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.0001); more diabetes complications (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.0001); and use more of glucose lowering drugs (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.0326); insulin (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.0001); chronic medicines (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.0001); and have higher diabetes duration (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.0088) than those without polypharmacy. 10.59% of the participants were found to have potential serious clinically relevant DDIs. The most frequent drug\u2010combinations were angiotensin\u2010converting enzyme (ACE) inhibitors with angiotensin\u2010receptor blockers (ARBs), aspirin with Selective serotonin reuptake inhibitors (SSRIs), and clopidogrel with calcium channel blockers. PIMs are found in 36.11% of the participants. The most common PIMs were benzodiazepines, long\u2010acting sulfonylureas, and iron overdose. The adjusted multivariate models show that Polypharmacy, PIMs, and potential serious clinically relevant DDIs were associated with lower QoL index scores (OR 1.80 95% CI 1.15\u20102.82), (OR 1.57 95% CI 1.07\u20102.28), and (OR 1.34 95% CI 0.73\u20102.48) respectively. The study shows that polypharmacy, potential serious clinical\u2010relevant DDIs, and PIMs may correlate with risk of reduced health related QoL outcome of older adults with T2D.\n                  <\/jats:p>","DOI":"10.1002\/prp2.621","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T00:13:52Z","timestamp":1593735232000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Polypharmacy, potentially serious clinically relevant drug\u2010drug interactions, and inappropriate medicines in elderly people with type 2 diabetes and their impact on quality of life"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3330-6343","authenticated-orcid":false,"given":"Labib","family":"AL\u2010Musawe","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy University of Lisbon Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Torre","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy University of Lisbon Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Pedro","family":"Guerreiro","sequence":"additional","affiliation":[{"name":"Centre for Health Evaluation &amp; Research (CEFAR) Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Teixeira","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Centre for Health Evaluation &amp; Research (CEFAR) Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao Filipe","family":"Raposo","sequence":"additional","affiliation":[{"name":"Nova Medical School Nova University of Lisbon Lisbon Portugal"},{"name":"Portuguese Diabetes Association (APDP) Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helder","family":"Mota\u2010Filipe","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy University of Lisbon Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Martins","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy University of Lisbon Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,2]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","first-page":"2018","article-title":"Global prevalence of Type 2 diabetes over the next ten years (2018\u20132028)","volume":"67","author":"Kaiser AB","year":"2018","journal-title":"Diabetes"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025369623365"},{"issue":"1","key":"e_1_2_11_4_1","first-page":"S139","article-title":"Standards of medical care in diabetes\u20142019","volume":"42","author":"Adults O","year":"2019","journal-title":"Diabetes Care"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2012.02.018"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2014.08.017"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(05)70164-X"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/diaspect.15.4.240"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12854"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2009.10.019"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12894"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S170134"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-017-0621-2"},{"key":"e_1_2_11_14_1","volume-title":"IBM Micromedex\u00ae DRUGDEX\u00ae (electronic version)","author":"Watson HI","year":"2019"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afu145"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13884"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afp058"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-012-9733-0"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-013-0448-z"},{"issue":"6","key":"e_1_2_11_20_1","doi-asserted-by":"crossref","first-page":"664","DOI":"10.20344\/amp.1317","article-title":"Contributos para a Valida\u00e7\u00e3o da Vers\u00e3o Portuguesa do EQ\u20105D Contribution for the Validation of the Portuguese Version of EQ\u20105D","volume":"26","author":"Ferreira PL","year":"2013","journal-title":"Acta Med Port"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-013-0488-4"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.006"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-015-0790-4"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2017.08.501"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2018.06.018"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regg.2011.03.002"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6904-9-11"},{"issue":"11","key":"e_1_2_11_28_1","first-page":"1867","article-title":"Gender differences, polypharmacy, and potential pharmacological interactions in the elderly","volume":"66","author":"Venturini CD","year":"2011","journal-title":"Clinics (Sao Paulo)"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2011.01.004"},{"issue":"519","key":"e_1_2_11_30_1","first-page":"743","article-title":"The impact of obesity on drug prescribing in primary care","volume":"55","author":"Gibbs H","year":"2005","journal-title":"Br J Gen Pract"},{"issue":"8","key":"e_1_2_11_31_1","doi-asserted-by":"crossref","first-page":"e017430","DOI":"10.1136\/bmjopen-2017-017430","article-title":"Associations between polypharmacy and treatment intensity for hypertension and diabetes: A cross\u2010sectional study of nursing home patients in British Columbia","volume":"7","author":"McCracken R","year":"2017","journal-title":"Canada. 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