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Neither a vaccine nor specific therapeutic approaches are available, hindering the fight against this disease and making better understanding of its pathogenesis essential. Despite similarities between SARS\u2010CoV\u20102 and SARS\u2010CoV, the former has unique characteristics which represent a great challenge to physicians. The mechanism of COVID\u201019 infection and pathogenesis is still poorly understood. In the present review, we highlight possible pathways involved in the pathogenesis of COVID\u201019 and potential therapeutic targets, focusing on the role of the renin\u2013angiotensin\u2013aldosterone system.<\/jats:p>","DOI":"10.1002\/prp2.623","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T12:46:07Z","timestamp":1594644367000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The renin\u2013angiotensin\u2013aldosterone system: Role in pathogenesis and potential therapeutic target in COVID\u201019"],"prefix":"10.1002","volume":"8","author":[{"given":"C\u00e1ssia L.","family":"Braga","sequence":"first","affiliation":[{"name":"Laboratory of Pulmonary Investigation Carlos Chagas Filho Institute of Biophysics Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1975-8033","authenticated-orcid":false,"given":"Rodrigo P.","family":"Silva\u2010Aguiar","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Cell Signalling Carlos Chagas Filho Institute of Biophysics Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Battaglini","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Ospedale Policlinico San Martino IRCCS for Oncology and Neuroscience Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7572-9731","authenticated-orcid":false,"given":"Diogo B.","family":"Peruchetti","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Cell Signalling Carlos Chagas Filho Institute of Biophysics Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Robba","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Ospedale Policlinico San Martino IRCCS for Oncology and Neuroscience Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Pelosi","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Ospedale Policlinico San Martino IRCCS for Oncology and Neuroscience Genoa Italy"},{"name":"Department of Surgical Sciences and Integrated Diagnostic (DISC) University of Genoa Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia R. 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