{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:31:36Z","timestamp":1788921096616,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,8,24]],"date-time":"2014-08-24T00:00:00Z","timestamp":1408838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology of Japan","doi-asserted-by":"crossref","award":["25871236"],"award-info":[{"award-number":["25871236"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology of Japan","doi-asserted-by":"crossref","award":["24790791"],"award-info":[{"award-number":["24790791"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013642","name":"Japan Heart Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013642","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although ghrelin has been demonstrated to improve cardiac function in heart failure, its therapeutic efficacy on the life expectancy remains unknown. We aim to examine whether ghrelin can improve the life survival in heart failure using a mouse model of inherited dilated cardiomyopathy (<jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>) caused by a deletion mutation \u0394K210 in cardiac troponin T (<jats:styled-content style=\"fixed-case\">cTnT<\/jats:styled-content>). From 30\u00a0days of age, ghrelin (150\u00a0<jats:italic>\u03bc<\/jats:italic>g\/kg) was administered subcutaneously to <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content> mice once daily, control mice received saline only. The survival rates were compared between the two groups for 30\u00a0days. After 30\u2010day treatment, functional and morphological measurements were conducted. Ghrelin\u2010treated <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content> mice had significantly prolonged life spans compared with saline\u2010treated control <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content> mice. Echocardiography showed that ghrelin reduced left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) end\u2010diastolic dimensions and increased <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> ejection fraction. Moreover, histoanatomical data revealed that ghrelin decreased the heart\u2010to\u2010body weight ratio, prevented cardiac remodeling and fibrosis, and markedly decreased the expression of brain natriuretic peptide. Telemetry recording and heart rate variability analysis showed that ghrelin suppressed the excessive cardiac sympathetic nerve activity (<jats:styled-content style=\"fixed-case\">CSNA<\/jats:styled-content>) and recovered the cardiac parasympathetic nerve activity. These results suggest that ghrelin has therapeutic benefits for survival as well as for the cardiac function and remodeling in heart failure probably through suppression of <jats:styled-content style=\"fixed-case\">CSNA<\/jats:styled-content> and recovery of cardiac parasympathetic nerve activity.<\/jats:p>","DOI":"10.1002\/prp2.64","type":"journal-article","created":{"date-parts":[[2014,8,25]],"date-time":"2014-08-25T01:27:52Z","timestamp":1408930072000},"source":"Crossref","is-referenced-by-count":18,"title":["Survival benefit of ghrelin in the heart failure due to dilated cardiomyopathy"],"prefix":"10.1002","volume":"2","author":[{"given":"Cheng\u2010Kun","family":"Du","sequence":"first","affiliation":[{"name":"Department of Cardiac Physiology National Cerebral and Cardiovascular Center Research Institute Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Yun","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Cardiac 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