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There is no vaccine to prevent infection with the causative organism, severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102), nor a cure. In the struggle to devise potentially useful therapeutics in record time, the repurposing of existing compounds is a key route of action. In this hypothesis paper, we argue that the bisbenzylisoquinoline and calcium channel blocker tetrandrine, originally extracted from the plant Stephania tetrandra and utilized in traditional Chinese medicine, may have potential in the treatment of COVID\u201019 and should be further investigated. We collate and review evidence for tetrandrine's putative mechanism of action in viral infection, specifically its recently discovered antagonism of the two\u2010pore channel 2 (TPC2). While tetrandrine's particular history of use provides a very limited pharmacological dataset, there is a suggestion from the available evidence that it could be effective at doses used in clinical practice. We suggest that further research to investigate this possibility should be conducted.<\/jats:p>","DOI":"10.1002\/prp2.653","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T18:27:05Z","timestamp":1601317625000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID\u201019"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7207-869X","authenticated-orcid":false,"given":"Paula M.","family":"Heister","sequence":"first","affiliation":[{"name":"University of Cambridge Cambridge United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin N.","family":"Poston","sequence":"additional","affiliation":[{"name":"Queen Mary University of London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0021-9258(18)75199-5","article-title":"The alkaloids of han\u2010fang\u2010chi","volume":"109","author":"Chen KK","year":"1935","journal-title":"J Biol Chem"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3466.1998.tb00341.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-020-09673-w"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0OB00078G"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules16098020"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.10.116"},{"key":"e_1_2_12_8_1","first-page":"400","volume-title":"harmacology and Applications of Chinese Materia Medica (Volume I)","author":"Shangbin Q","year":"1986"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15562-9"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1258758"},{"key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1016\/S0021-9258(18)69196-3","article-title":"Interaction of tetrandrine with slowly inactivating calcium channels. 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