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Even though the focus on RWE studies has increased in Colombia, the availability of secondary data sources to perform this type of research is not well documented. Thus, we aimed at identifying and characterizing secondary data sources available in Colombia. We performed a systematic literature review on PubMed, EMBASE, and VHL using a combination of controlled vocabulary and keywords for the concepts of electronic health records, epidemiologic studies and Colombia. A total of 323 publications were included. These comprised 123 identified secondary data sources including pharmacy dispensing databases, government datasets, disease registries, insurance databases, and electronic heath records, among others. These data sources were mostly used for cross\u2010sectional studies focused on disease epidemiology in a specific population. Almost all databases (95%) contained demographic information, followed by pharmacological treatment (44%) and diagnostic tests (39%). Even though the database owner was identifiable in 94%, access information was only available in 44% of the articles. Only a pharmacy\u2010dispensing database, local cancer registries, and government databases included a description regarding the quality of the information available. The diversity of databases identified shows that Colombia has a high potential to continue enhancing its RWE strategy. Greater efforts are required to improve data quality and accessibility. The linkage between databases will expand data pooling and integration to boost the translational potential of RWE.<\/jats:p>","DOI":"10.1002\/prp2.661","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T14:27:00Z","timestamp":1600871220000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Availability of secondary healthcare data for conducting pharmacoepidemiology studies in Colombia: A systematic review"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7776-9270","authenticated-orcid":false,"given":"Juan\u2010Sebastian","family":"Franco","sequence":"first","affiliation":[{"name":"Medical Affairs Bayer S.A Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0248-7636","authenticated-orcid":false,"given":"David","family":"Vizcaya","sequence":"additional","affiliation":[{"name":"Epidemiology Bayer Hispania Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2007.00186.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3896"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-013-1496-6"},{"key":"e_1_2_11_5_1","unstructured":"European Medicines Agency (EMA).Guideline on good pharmacovigilance practices (GVP) \u2010 Module VIII \u2010 Post\u2010authorization safety studies (Rev. 3) EMA\/813938\/2011 Rev 3*. 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