{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:30:32Z","timestamp":1790951432746,"version":"4.1.0"},"reference-count":132,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clopidogrel is the most common and widely used antiplatelet agent for patients with coronary artery disease following confirmation by electrocardiographic studies. The nonresponsiveness of patients to clopidogrel and the possibility of testing for clopidogrel resistance by platelet function assays (PFA) are contentious issues. Light transmission aggregometry (LTA) is considered as the gold standard test among all PFA. In this review, the most commonly used PFA used for monitoring the effect of clopidogrel, LTA, vasodilator\u2010stimulated phosphoprotein assay phosphorylation, rotational thromboelastometry (ROTEM) delta and ROTEM platelet, thromboelastography, PFA\u2010100, VerifyNow P2Y12 assay, Multiplate analyzer, Plateletworks assay and pharmacogenetic studies, are comparatively discussed including their principles of action, advantages, and disadvantages. VerifyNow P2Y12 assay can be accepted as the ideal point of care test out of the discussed assays. However, modified assays are required which could overcome the limitations associated with currently available assays.<\/jats:p>","DOI":"10.1002\/prp2.686","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T13:28:17Z","timestamp":1605619697000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Pharmacokinetic, pharmacodynamic, and pharmacogenetic assays to monitor clopidogrel therapy"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6166-122X","authenticated-orcid":false,"given":"Bhawani Yasassri","family":"Alvitigala","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Science Faculty of Health Sciences The Open University of Sri Lanka Nugegoda Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lallindra Viranjan","family":"Gooneratne","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine University of Colombo Colombo Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Godwin Roger","family":"Constantine","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Faculty of Medicine University of Colombo Colombo Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajapaksha Arachchige Namal Kumarasiri","family":"Wijesinghe","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Faculty of Medicine General Sir John Kotelawala Defense University Ratmalana Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyanage Dona Ashanthi Menuka","family":"Arawwawala","sequence":"additional","affiliation":[{"name":"Research &amp; Development Complex Industrial Technology Institute Malabe Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-03-742338"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jccase.2016.01.001"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5922.2010.00202.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-15-0546"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.26013"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e3283385420"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06373-0"},{"issue":"3","key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.20883\/medical.e70","article-title":"The influence of diabetic status on the pharmacokinetics of clopidogrel and its metabolites in patients suffered from cardiovascular diseases","volume":"83","author":"Kara\u017aniewicz\u2010Lada M","year":"2014","journal-title":"J Med Sci"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.323"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108991"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV7I4A73"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12111"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.01.034"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5922.2011.00296.x"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihj.2014.08.012"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3329\/jemc.v6i1.26381"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.2013.07.2682"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S9087"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3181ee08ed"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808227"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2002.01027.x"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000072771.11429.83"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2004.07.036"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.059535"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.4137\/CMC.S2159"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.4065\/81.4.518"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.675991"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20122967"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-bioeng-071516-044539"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.310367"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2006.08.012"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.2174\/1876506800902020024"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12952"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2013.05.012"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.5528\/wjtm.v3.i2.69"},{"key":"e_1_2_12_37_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/456569","article-title":"Platelet function tests: a review of progresses in clinical application","volume":"2014","author":"Choi J\u2010L","year":"2014","journal-title":"BioMed Res Int"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12240"},{"issue":"2","key":"e_1_2_12_39_1","first-page":"208","article-title":"Effect of shear rate on platelet interaction with subendothelium in citrated and native blood. II. Relationships among platelet adhesion, thrombus dimensions, and fibrin formation","volume":"95","author":"Baumgartner HR","year":"1980","journal-title":"J Lab Clin Med"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPYIQ9JNNSEN4Q"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2017.05.033"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000064326.65899.AC"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH06-05-0242"},{"issue":"3","key":"e_1_2_12_44_1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1515\/CCLM.2011.074","article-title":"Platelet function testing in hirudin and BAPA anticoagulated blood","volume":"49","author":"Mani H","year":"2010","journal-title":"Clin Chem Lab Med"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069417"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2011.03999.x"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.02.092"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.02891.x"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0917"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.22112"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plabm.2018.02.002"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-9560-7-4"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2004.01063.x"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.13005\/bpj\/1412"},{"key":"e_1_2_12_55_1","article-title":"Point\u2010of\u2010care platelet function tests: relevance to arterial thrombosis and opportunities for improvement","author":"Gorog DA","year":"2020","journal-title":"J Thromb Thrombolysis"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.5482\/HAMO-12-05-0011"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-28308-1_18"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006045"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2012.06.015"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2009.07.038"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-9784.191559"},{"key":"e_1_2_12_62_1","volume-title":"Thromboelastography (TEG)","author":"Shaydakov ME","year":"2020"},{"key":"e_1_2_12_63_1","volume-title":"Coronary Artery Disease Tufts","author":"Munther K","year":"2008"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2012.03.022"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200610000-00011"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aer298"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2013.03.003"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.080"},{"key":"e_1_2_12_69_1","unstructured":"Platelet function testing: PFA\u2010100.https:\/\/practical\u2010haemostasis.com\/Platelets\/pfa.html. Accessed August 16 2020"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12279"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPTE3K1SGAPOIZ"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03086004"},{"key":"e_1_2_12_73_1","unstructured":"Plateletworks POC platelet function test: SPEP test: Helena.com.https:\/\/www.helena.com\/plateletworks.html. Accessed August 16 2020"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03256290"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.181"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.3109\/14017431.2011.629677"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18081803"},{"issue":"5","key":"e_1_2_12_78_1","first-page":"22","article-title":"High performance liquid chromatography: a short review","volume":"2","author":"Malviya R","year":"2010","journal-title":"J Glob Pharma Technol"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-013-0105-2"},{"issue":"1","key":"e_1_2_12_80_1","first-page":"91","article-title":"Chromatographic determination of clopidogrel bisulfate; detection and quantification of counterfeit Plavix\u00ae tablets","volume":"52","author":"ElTantawy ME","year":"2014","journal-title":"Bull Fac Pharm Cairo Univ"},{"issue":"1","key":"e_1_2_12_81_1","first-page":"11","article-title":"Development of a new HPLC method for simultaneous determination of clopidogrel and its major metabolite using a chemometric approach","volume":"41","author":"Anuta V","year":"2015","journal-title":"Curr Health Sci J"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-09-0582"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.2174\/157341209789649131"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/892470"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.109.029132"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.115.001318"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8062796"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0b013e32835f0bbc"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.09.075"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.10.002"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046366"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e32835aa8a2"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2281"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2007.12.118"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2011.03949.x"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.08.018"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2011.0259"},{"key":"e_1_2_12_98_1","first-page":"90","volume-title":"Platelet Function Testing\u2010Guided Antiplatelet Therapy","author":"Lenk E","year":"2014"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2009.04.003"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn419"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199304000-00003"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(98)00020-6"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1053\/jcan.2002.126945"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2009.12.044"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.03.108"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13083"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28181-8"},{"issue":"1","key":"e_1_2_12_108_1","first-page":"21","article-title":"Role of VASP phosphorylation assay in monitoring the antiplatelet therapy","volume":"13","author":"Fedor M","year":"2013","journal-title":"Acta Med Martin"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.291.2820"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.112094"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029608322547"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSMBR.905246"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-009-0881-9"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2019.39.1.23"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crvasa.2012.08.003"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH07-07-0478"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-014-0230-6"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03733.x"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.15420\/icr.2013.8.2.100"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2963"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm226"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2957"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtumed.2016.08.002"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2011.03955.x"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S44469"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.047050"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2014.226332"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.04.047"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.06.059"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-28308-1"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2009.13"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2929"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1617036"}],"container-title":["Pharmacology Research &amp; Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prp2.686","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/prp2.686","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prp2.686","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T12:47:16Z","timestamp":1693658836000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/prp2.686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,17]]},"references-count":132,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/prp2.686"],"URL":"https:\/\/doi.org\/10.1002\/prp2.686","archive":["Portico"],"relation":{},"ISSN":["2052-1707","2052-1707"],"issn-type":[{"value":"2052-1707","type":"print"},{"value":"2052-1707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,17]]},"assertion":[{"value":"2020-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00686"}}