{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:30:33Z","timestamp":1768264233740,"version":"3.49.0"},"reference-count":204,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T00:00:00Z","timestamp":1609286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Coronaviruses represent global health threat. In this century, they have already caused two epidemics and one serious pandemic. Although, at present, there are no approved drugs and therapies for the treatment and prevention of human coronaviruses, several agents, FDA\u2010approved, and preclinical, have shown in vitro and\/or in vivo antiviral activity. An in\u2010depth analysis of the current situation leads to the identification of several potential drugs that could have an impact on the fight against coronaviruses infections. In this review, we discuss the virology of human coronaviruses highlighting the main biological targets and summarize the current state\u2010of\u2010the\u2010art of possible therapeutic options to inhibit coronaviruses infections. We mostly focus on FDA\u2010approved and preclinical drugs targeting viral conserved elements.<\/jats:p>","DOI":"10.1002\/prp2.691","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T00:51:09Z","timestamp":1609375869000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Therapeutic approaches against coronaviruses acute respiratory syndrome"],"prefix":"10.1002","volume":"9","author":[{"given":"Camilla","family":"Servidio","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Health and Nutrition Sciences University of Calabria Rende Italy"},{"name":"Institute of Materials Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL) Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4635-6080","authenticated-orcid":false,"given":"Francesco","family":"Stellacci","sequence":"additional","affiliation":[{"name":"Institute of Materials Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL) Lausanne Switzerland"},{"name":"Bioengineering Institute, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL) Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-020-0695-z"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.367.6478.610"},{"key":"e_1_2_9_5_1","unstructured":"https:\/\/www.who.int\/emergencies\/diseases\/novel\u2010coronavirus\u20102019\/situation\u2010reports."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.81"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2016.03.003"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.69.4.635-664.2005"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0118-9"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.08.015"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050828"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00102-14"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117839"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1143"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2013.06.003"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(20)30004-5"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25757"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1401505"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1118391"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409608102"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0820-9"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3985"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2006.02.041"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41587-020-00003-1"},{"key":"e_1_2_9_26_1","unstructured":"Unit N. I. H. R.Biggest COVID\u201019 trial tests repurposed drugs first."},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41573-020-00016-0"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30251-8"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-81-4-853"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-26765-4_1"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2015.02.025"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02145"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2179-y"},{"issue":"7440","key":"e_1_2_9_34_1","first-page":"39","article-title":"Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus\u2010EMC","volume":"495","author":"Osterhaus DME","year":"2015","journal-title":"Coronavirus Spike\u2010Receptor Interact"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1570"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/v11030280"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-10-0045"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00786"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0868-6"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03712"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1267"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/713609354"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02062-10"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01890-13"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1407087111"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.04.022"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0505577102"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107587"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25681"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2015.37"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10280-3"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25761"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202000047"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0282-0"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aal3653"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1177\/095632020401500102"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abb5883"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1983.03330430042027"},{"key":"e_1_2_9_60_1","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.1016\/0168-8278(91)91386-U","article-title":"Ribavirin therapy for chronic type C hepatitis","volume":"13","author":"Buti M","year":"1991","journal-title":"J Hepatol"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2005.01.003"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2013.09.029"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2006.03.001"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3362"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.21.JOC30885"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030685"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0906.030264"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13364-8"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70920-X"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1086\/378304"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep43395"},{"key":"e_1_2_9_72_1","unstructured":"https:\/\/www.who.int\/ebola\/drc\u20102018\/treatments\u2010approved\u2010for\u2010compassionate\u2010use\u2010update\/en\/."},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13940-6"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2007016"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2007764"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2009.02.198"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107512"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eng.2020.03.007"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13027"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117592"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02220-08"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2013.11.040"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2014.12.015"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03011-14"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.061911-0"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2014.12.011"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.01.005"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi0504761"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-020-0148-0"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01461"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb3405"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b01828"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2008.04.011"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.11.028"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2016.05.013"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2010.09.050"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.02.002"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2018.09.019"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm060207o"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.04.118"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.08.082"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21121628"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.553123"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgt366"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41187-0"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b00299"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2223-y"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-020-0440-6"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm070295s"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13659-4"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.0c00052"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:PHAM.0000041457.64638.8d"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2020.104786"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv392"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.2003.012658"},{"issue":"6","key":"e_1_2_9_116_1","first-page":"399","article-title":"Treatment of severe acute respiratory syndrome with lopinavir\/ritonavir: a multicentre retrospective matched cohort study","volume":"9","author":"Chan KS","year":"2003","journal-title":"Hong Kong Med J"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001282"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31042-4"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.04.083"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.3390\/v4061011"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0305-x"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aav4580"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.3390\/v8100296"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02322-09"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2016.07.011"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.09.028"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00754-20"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(20)30145-9"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16727"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00415-08"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2008.15"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03036-14"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00023-19"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.716100"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.3390\/v10060283"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-019-0132-8"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(03)00806-5"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.105938"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.3.1534"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-2-69"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.5582\/bst.2020.01047"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.105949"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.106056"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30172-7"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2012410"},{"key":"e_1_2_9_146_1","article-title":"Clinical efficacy of hydroxychloroquine in patients with covid\u201019 pneumonia who require oxygen: observational comparative study using routine care data","volume":"369","author":"Mah\u00e9vas M","year":"2020","journal-title":"BMJ"},{"key":"e_1_2_9_147_1","article-title":"Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID\u201019: a multinational registry analysis","author":"Mehra MR","year":"2020","journal-title":"Lancet"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.8630"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.04.004"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.0c02278"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2090"},{"issue":"2","key":"e_1_2_9_152_1","first-page":"152","article-title":"Convalescent plasma: new evidence for an old therapeutic tool?","volume":"14","author":"Marano G","year":"2016","journal-title":"Blood Transfus"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2004.00956.x"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-004-1271-9"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-015-1490-9"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4783"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2004168117"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102554"},{"key":"e_1_2_9_159_1","first-page":"1","article-title":"Passive antibody therapy in COVID\u201019","volume":"12","author":"Abraham J","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2005.01.033"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.10245"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16506-9"},{"key":"e_1_2_9_163_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2017.1271415"},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2020.03.007"},{"key":"e_1_2_9_165_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008140"},{"key":"e_1_2_9_166_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0701000104"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1510199112"},{"key":"e_1_2_9_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2349-y"},{"key":"e_1_2_9_169_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc7424"},{"key":"e_1_2_9_170_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19854-y"},{"key":"e_1_2_9_171_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb7269"},{"key":"e_1_2_9_172_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2380-z"},{"key":"e_1_2_9_173_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc6952"},{"key":"e_1_2_9_174_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10897-4"},{"key":"e_1_2_9_175_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2538-8"},{"key":"e_1_2_9_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-020-00789-5"},{"issue":"3","key":"e_1_2_9_177_1","first-page":"25","article-title":"Antibody\u2010dependent enhancement of SARS coronavirus infection and its role in the pathogenesis of SARS","volume":"22","author":"Yip MS","year":"2016","journal-title":"Hong Kong Med J"},{"key":"e_1_2_9_178_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit504"},{"key":"e_1_2_9_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30193-4"},{"key":"e_1_2_9_180_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.6b00006"},{"key":"e_1_2_9_181_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0577-1"},{"key":"e_1_2_9_182_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1121"},{"key":"e_1_2_9_183_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14752"},{"key":"e_1_2_9_184_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01043-16"},{"key":"e_1_2_9_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2015.01.011"},{"key":"e_1_2_9_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep22008"},{"key":"e_1_2_9_187_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03977-14"},{"key":"e_1_2_9_188_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.11.7095-7103.2005"},{"key":"e_1_2_9_189_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm0603926"},{"key":"e_1_2_9_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.03.004"},{"key":"e_1_2_9_191_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028479"},{"key":"e_1_2_9_192_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805240105"},{"key":"e_1_2_9_193_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403596101"},{"key":"e_1_2_9_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104960"},{"key":"e_1_2_9_195_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002331"},{"key":"e_1_2_9_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2016.11.011"},{"key":"e_1_2_9_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2016.04.001"},{"key":"e_1_2_9_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2020.104787"},{"key":"e_1_2_9_199_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200701021"},{"key":"e_1_2_9_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2017.12.015"},{"key":"e_1_2_9_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2012.10.053"},{"key":"e_1_2_9_202_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M807947200"},{"key":"e_1_2_9_203_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2017.02.007"},{"key":"e_1_2_9_204_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.09.014"},{"key":"e_1_2_9_205_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0809400106"}],"container-title":["Pharmacology Research &amp; Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prp2.691","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/prp2.691","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prp2.691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T00:29:48Z","timestamp":1693700988000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/prp2.691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,30]]},"references-count":204,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1002\/prp2.691"],"URL":"https:\/\/doi.org\/10.1002\/prp2.691","archive":["Portico"],"relation":{},"ISSN":["2052-1707","2052-1707"],"issn-type":[{"value":"2052-1707","type":"print"},{"value":"2052-1707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,30]]},"assertion":[{"value":"2020-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00691"}}