{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:12:07Z","timestamp":1791483127935,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T00:00:00Z","timestamp":1608336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Some patients in the community receive a high burden of antibiotics. We aimed at describing the characteristics of these patients, antibiotics used, and conditions for which they received antibiotics. We carried out a cross\u2010sectional study. Setting: Thirty Health Primary Care Areas from 12 regions in Spain, covering 5,960,191 inhabitants. Patients having at least 30 packages of antibacterials for systemic use dispensed in 2017 were considered. Main outcome measures: Prevalence of antibiotic use, conditions for which antibiotics were prescribed, clinical characteristics of patients, comorbidities, concomitant treatments, and microbiological isolates. Patient\u2019s average age was 70 years; 52% were men; 60% smokers\/ex\u2010smokers; 54% obese. Overall, 93% of patients had, at least, one chronic condition, and four comorbidities on average. Most common comorbidities were cardiovascular and\/or hypertension (67%), respiratory diseases (62%), neurological\/mental conditions (32%), diabetes (23%), and urological diseases (21%); 29% were immunosuppressed, 10% were dead at the time of data collection. Patients received three antibiotic treatments per year, mainly fluoroquinolones (28%), macrolides (21%), penicillins (19%), or cephalosporins (12%). Most frequently treated conditions were lower respiratory tract (infections or prophylaxis) (48%), urinary (27%), and skin\/soft tissue infections (11%). Thirty\u2010five percent have been guided by a microbiological diagnosis, being <jats:italic>Pseudomonas aeruginosa<\/jats:italic> (30%) <jats:italic>and Escherichia coli<\/jats:italic> (16%) the most frequent isolates. In conclusion, high antibiotic consumers in the community were basically elder, with multimorbidity and polymedication. They frequently received broad\u2010spectrum antibiotics for long periods of time. The approach to infections in high consumers should be differentiated from healthy patients receiving antibiotics occasionally.<\/jats:p>","DOI":"10.1002\/prp2.692","type":"journal-article","created":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T12:00:51Z","timestamp":1608379251000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Patients receiving a high burden of antibiotics in the community in Spain: a cross\u2010sectional study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6261-6869","authenticated-orcid":false,"given":"Roc\u00edo","family":"Fern\u00e1ndez\u2010Urrusuno","sequence":"first","affiliation":[{"name":"Clinical Unit Primary Care Pharmacy Sevilla Aljarafe\u2010Sevilla Norte Primary Health Area Andalusian Health Service Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Marina","family":"Meseguer Barros","sequence":"additional","affiliation":[{"name":"Service of Pharmacy Ouest Primary Health Care Area Madrid Health Service Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Anaya\u2010Ord\u00f3\u00f1ez","sequence":"additional","affiliation":[{"name":"Service of Pharmacy Granada Metropolitano Primary Health Care Area Andalusian Health Service Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Borrego Izquierdo","sequence":"additional","affiliation":[{"name":"Cantabria Primary Care Management Cantabrian Health Service Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jes\u00fas","family":"Lallana\u2010\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Service of Primary Care Pharmacy Arag\u00f3n Health Service Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Madridejos","sequence":"additional","affiliation":[{"name":"Service of Pharmacy Mutua Terrasa Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther Marco","family":"Tej\u00f3n","sequence":"additional","affiliation":[{"name":"Cuenca Primary Care Management Hospital Virgen de la Luz Castilla La Mancha Health Service Cuenca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel Prieto","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Cantabria Primary Care Management Cantabrian Health Service Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olatz","family":"P\u00e9rez Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Mallorca Primary Care Management Islas Baleares Health Service IB\u2010SALUT Palma de Mallorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Garc\u00eda Gil","sequence":"additional","affiliation":[{"name":"Service of Pharmacy Sagunto Health Care Area Comunidad Valenciana Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Escudero Vilaplana","sequence":"additional","affiliation":[{"name":"Service of Pharmacy Ouest Primary Health Care Area Madrid Health Service Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genma M. Silva","family":"Ri\u00e1digos","sequence":"additional","affiliation":[{"name":"Service of Pharmacy Ouest Primary Health Care Area Madrid Health Service Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Sagrario Pardo","family":"L\u00f3pez\u2010Fando","sequence":"additional","affiliation":[{"name":"Service of Pharmacy North Primary Health Care Area Madrid Health Service Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Olmo Quintana","sequence":"additional","affiliation":[{"name":"Service of Pharmacy Gran Canaria Primary Care Management Canarian Health Service Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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