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There is growing evidence that appetite hormones, including peptide YY (PYY), which modulates craving and satiety responses, play a role in stress and addiction processes. This study employed a quasi\u2010experimental design to examine the association between ELA and circulating PYY stress responses in smokers and nonsmokers (<jats:italic>N<\/jats:italic>\u2009=\u2009152, ages 19\u201373\u2009years) to examine the effects of nicotine addiction. Smokers initiated a quit attempt as part of the study and were classified as either abstinent smokers or relapsed smokers based on their nicotine use during the follow\u2010up period. PYY levels were measured at five timepoints during three lab sessions and compared between nonsmokers and the two smoking groups (abstainers, relapsers): while smokers were using nicotine ad\u00a0libitum, 24\u2009h after smokers initiated a quit attempt, and 4\u2009weeks after smokers initiated a quit attempt. Multivariate analyses showed the main effects of time on PYY, which decreased over time within each session. The main effects of ELA during the first (ad libitum smoking) and second (24\u2010h post\u2010cessation for smokers) sessions indicated that experiencing ELA was associated with lower PYY. No systematic effect of nicotine addiction or relapse was observed in this study. These findings suggest that adults with higher ELA may experience lower PYY. Additional research is needed to further explore the role of PYY in stress and addiction processes.<\/jats:p>","DOI":"10.1002\/prp2.70016","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T12:58:49Z","timestamp":1727182729000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Nicotine addiction and the influence of life adversity and acute stress on PYY: Prediction of early smoking relapse"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1247-6463","authenticated-orcid":false,"given":"Amanda A.","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Family Medicine and Biobehavioral Health University of Minnesota Medical School  Duluth Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3153-6372","authenticated-orcid":false,"given":"Motohiro","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Biobehavioral Health University of Minnesota Medical School  Duluth Minnesota USA"},{"name":"Eikei University of Hiroshima  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6001-8497","authenticated-orcid":false,"given":"Briana N.","family":"DeAngelis","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Biobehavioral Health University of Minnesota Medical School  Duluth Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1108-2609","authenticated-orcid":false,"given":"Dorothy K.","family":"Hatsukami","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; 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