{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:12:35Z","timestamp":1793643155209,"version":"4.5.1"},"reference-count":101,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.829284\/2023\u201000"],"award-info":[{"award-number":["88887.829284\/2023\u201000"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sarcopenia is characterized by a decline in muscle strength, generalized loss of skeletal muscle mass, and impaired physical performance, which are common outcomes used to screen, diagnose, and determine severity of sarcopenia in older adults. These outcomes are associated with poor quality of life, increased risk of falls, hospitalization, and mortality in this population. The development of sarcopenia is underpinned by aging, but other factors can lead to sarcopenia, such as chronic diseases, physical inactivity, inadequate dietary energy intake, and reduced protein intake (nutrition\u2010related sarcopenia), leading to an imbalance between muscle protein synthesis and muscle protein breakdown. Protein digestion and absorption are also modified with age, as well as the reduced capacity of metabolizing protein, hindering older adults from achieving ideal protein consumption (i.e., 1\u20131.5\u2009g\/kg\/day). Nutritional supplement strategies, like animal (i.e., whey protein) and plant\u2010based protein, leucine, and creatine have been shown to play a significant role in improving outcomes related to sarcopenia. However, the impact of other supplements (e.g., branched\u2010chain amino acids, isolated amino acids, and omega\u20103) on sarcopenia and related outcomes remain unclear. This narrative review will discuss the evidence of the impact of these nutritional strategies on sarcopenia outcomes in older adults.<\/jats:p>","DOI":"10.1002\/prp2.70019","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T08:39:58Z","timestamp":1728895198000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Nutritional strategies for improving sarcopenia outcomes in older adults: A narrative review"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9276-8898","authenticated-orcid":false,"given":"Beatriz R.","family":"Goes\u2010Santos","sequence":"first","affiliation":[{"name":"School of Physical Education State University of Campinas (FEF\u2010UNICAMP)  Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8350-1481","authenticated-orcid":false,"given":"Brian P.","family":"Carson","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport Sciences, Faculty of Education and Health Sciences University of Limerick  Limerick Ireland"},{"name":"Health Research Institute University of Limerick  Limerick Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6477-8741","authenticated-orcid":false,"given":"Guilherme Wesley Peixoto","family":"da Fonseca","sequence":"additional","affiliation":[{"name":"School of Physical Education and Sport University of S\u00e3o Paulo (EEFE\u2010USP)  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9818-042X","authenticated-orcid":false,"given":"Stephan","family":"von Haehling","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology University of G\u00f6ttingen Medical Center  G\u00f6ttingen Germany"},{"name":"German Center for Cardiovascular Research (DZHK), partner site G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,14]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy169"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12147"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31138-9"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq034"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12545"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40200-017-0302-x"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S407917"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-041879"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2023.155533"},{"key":"e_1_2_17_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12483"},{"key":"e_1_2_17_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101200"},{"key":"e_1_2_17_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12784"},{"key":"e_1_2_17_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-017-0345-5"},{"key":"e_1_2_17_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665124002192"},{"key":"e_1_2_17_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101731"},{"key":"e_1_2_17_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000855"},{"key":"e_1_2_17_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665120008010"},{"key":"e_1_2_17_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom9110642"},{"key":"e_1_2_17_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2013.05.021"},{"key":"e_1_2_17_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8612992"},{"key":"e_1_2_17_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/bega.2001.0262"},{"key":"e_1_2_17_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000228556"},{"key":"e_1_2_17_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0210-x"},{"key":"e_1_2_17_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13103519"},{"key":"e_1_2_17_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu103"},{"key":"e_1_2_17_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140903"},{"key":"e_1_2_17_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-015-0500-5"},{"key":"e_1_2_17_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2014.04.007"},{"key":"e_1_2_17_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12922"},{"key":"e_1_2_17_31_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms\/167799"},{"key":"e_1_2_17_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15184073"},{"key":"e_1_2_17_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.01045"},{"key":"e_1_2_17_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxaa049"},{"key":"e_1_2_17_35_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.244897"},{"key":"e_1_2_17_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7125496"},{"key":"e_1_2_17_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109336"},{"key":"e_1_2_17_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2020.00025"},{"key":"e_1_2_17_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-019-1174-1"},{"key":"e_1_2_17_40_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511007422"},{"key":"e_1_2_17_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxy263"},{"key":"e_1_2_17_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10050563"},{"key":"e_1_2_17_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqaa372"},{"key":"e_1_2_17_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqz332"},{"key":"e_1_2_17_45_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114515002810"},{"key":"e_1_2_17_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020647"},{"key":"e_1_2_17_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-023-03295-6"},{"key":"e_1_2_17_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxac222"},{"key":"e_1_2_17_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2011.03776.x"},{"key":"e_1_2_17_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2021.06.024"},{"key":"e_1_2_17_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11051072"},{"key":"e_1_2_17_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12937-016-0130-8"},{"key":"e_1_2_17_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10010097"},{"key":"e_1_2_17_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12020307"},{"key":"e_1_2_17_55_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.013722"},{"key":"e_1_2_17_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.14970"},{"key":"e_1_2_17_57_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114512001717"},{"key":"e_1_2_17_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12970-019-0318-3"},{"key":"e_1_2_17_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/1550-2783-9-14"},{"key":"e_1_2_17_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/1550-2783-10-29"},{"key":"e_1_2_17_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/md19020062"},{"key":"e_1_2_17_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032001"},{"key":"e_1_2_17_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-021-01540-8"},{"key":"e_1_2_17_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-021-01434-9"},{"key":"e_1_2_17_65_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114521000635"},{"key":"e_1_2_17_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjnut.2023.11.004"},{"key":"e_1_2_17_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.7.1835S"},{"key":"e_1_2_17_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gly109"},{"key":"e_1_2_17_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.2.139"},{"key":"e_1_2_17_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.10.2413"},{"key":"e_1_2_17_71_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1992.263.5.E928"},{"key":"e_1_2_17_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-014-0152-3"},{"key":"e_1_2_17_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12040932"},{"key":"e_1_2_17_74_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S75271"},{"key":"e_1_2_17_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqx028"},{"key":"e_1_2_17_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuaa011"},{"key":"e_1_2_17_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.04.025"},{"key":"e_1_2_17_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2017.09.008"},{"key":"e_1_2_17_79_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12061816"},{"key":"e_1_2_17_80_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00488.2005"},{"key":"e_1_2_17_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt152"},{"key":"e_1_2_17_82_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13051522"},{"key":"e_1_2_17_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqz120"},{"key":"e_1_2_17_84_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103576"},{"key":"e_1_2_17_85_1","doi-asserted-by":"publisher","DOI":"10.3389\/fspor.2023.1171220"},{"key":"e_1_2_17_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-021-02710-0"},{"key":"e_1_2_17_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12970-017-0173-z"},{"key":"e_1_2_17_88_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13030745"},{"key":"e_1_2_17_89_1","doi-asserted-by":"publisher","DOI":"10.2147\/OAJSM.S123529"},{"key":"e_1_2_17_90_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2014-0498"},{"key":"e_1_2_17_91_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2019-0066"},{"key":"e_1_2_17_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2014.02.003"},{"key":"e_1_2_17_93_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000220"},{"key":"e_1_2_17_94_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17093041"},{"key":"e_1_2_17_95_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-food-111317-095850"},{"key":"e_1_2_17_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12936"},{"key":"e_1_2_17_97_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.114.105833"},{"key":"e_1_2_17_98_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14173537"},{"key":"e_1_2_17_99_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.005611"},{"key":"e_1_2_17_100_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2014-202560"},{"key":"e_1_2_17_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2021.09.729"},{"key":"e_1_2_17_102_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.16909"}],"container-title":["Pharmacology Research &amp; Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prp2.70019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T07:39:50Z","timestamp":1729150790000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/prp2.70019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":101,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/prp2.70019"],"URL":"https:\/\/doi.org\/10.1002\/prp2.70019","archive":["Portico"],"relation":{},"ISSN":["2052-1707","2052-1707"],"issn-type":[{"value":"2052-1707","type":"print"},{"value":"2052-1707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2024-02-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70019"}}