{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:50:24Z","timestamp":1792518624951,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:00Z","timestamp":1727827200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019345","name":"King Salman Center for Disability Research","doi-asserted-by":"publisher","award":["KSRG\u20102023\u2010109"],"award-info":[{"award-number":["KSRG\u20102023\u2010109"]}],"id":[{"id":"10.13039\/501100019345","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nephrotoxicity occurs when the body is exposed to certain drugs or toxins. When kidney damage occurs, the kidney fails to eliminate excess urine and waste. Solanesol (C45H74O) is a tri\u2010sesquiterpenoid alcohol first isolated from tobacco, and it is widely distributed in plants of the Solanaceae family. Solanesol (SNL) is an intermediate in the synthesis of coenzyme Q10 (CoQ10), an antioxidant which protects nerve cells. This study investigated the protective effect of SNL at doses of 30 and 60\u2009mg\/kg in gentamicin\u2010induced nephrotoxicity in Wistar albino rats. Animals were distributed into six groups and administered 100\u2009mg\/kg gentamicin\u2010intraperitoneal injection for 14\u2009days. Biochemical assessments were performed on kidney homogenate, blood, and serum. Treatment with SNL was shown as lower serum levels of creatinine, blood urea nitrogen (BUN), thiobarbituric acid reactive substances (TBARS), and Tumor necrosis factor alpha)TNF\u2010\u03b1 ((<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). It also restored reduced glutathione (GSH) and mitochondrial complex enzymatic activity as protective measures against gentamicin\u2010induced nephrotoxicity. SNL were shown to reduce inflammation and oxidative stress markers (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Histological findings furtherly augmented the protective effects of SNL. Long\u2010term SNL therapy also restored mitochondrial electron transport chain complex enzymes, such as complex\u2010I (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). In conclusion, these findings suggest that SNL can represent a protective therapeutic option for drug\u2010induced nephrotoxicity, a long\u2010term adverse effect of aminoglycoside antibiotics such as gentamicin.<\/jats:p>","DOI":"10.1002\/prp2.70022","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T05:10:37Z","timestamp":1727932237000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of mitochondrial coenzyme\u2010<scp>Q10<\/scp> precursor solanesol in gentamicin\u2010induced experimental nephrotoxicity: Evidence from restoration of <scp>ETC<\/scp>\u2010complexes and histopathological alterations"],"prefix":"10.1002","volume":"12","author":[{"given":"Minakshi","family":"Sangwan","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Science PDM University  Bahadurgarh Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hema","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science PDM University  Bahadurgarh Haryana India"},{"name":"School of Medical and Allied Sciences K R Mangalam University  Gurugram India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0034-835X","authenticated-orcid":false,"given":"Sidharth","family":"Mehan","sequence":"additional","affiliation":[{"name":"Division of Neuroscience, Department of Pharmacology ISF College of Pharmacy (An Autonomous (College)  Moga Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuber","family":"Khan","sequence":"additional","affiliation":[{"name":"Division of Neuroscience, Department of Pharmacology ISF College of Pharmacy (An Autonomous (College)  Moga Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammar A.","family":"Bahauddin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology College of Pharmacy Taibah University  Medina Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bandar D.","family":"Alrehaili","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology College of Pharmacy Taibah University  Medina Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein M.","family":"Elbadawy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology College of Pharmacy Taibah University  Medina Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohannad A.","family":"Almikhlafi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology College of Pharmacy Taibah University  Medina Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Acharan S.","family":"Narula","sequence":"additional","affiliation":[{"name":"Narula Research LLC  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reni","family":"Kalfin","sequence":"additional","affiliation":[{"name":"Institute of Neurobiology Bulgarian Academy of Sciences  Sofia Bulgaria"},{"name":"Department of Healthcare South\u2010West University Blagoevgrad  Blagoevgrad Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7109-939X","authenticated-orcid":false,"given":"Hanna","family":"Wanas","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology College of Pharmacy Taibah University  Medina Kingdom of Saudi Arabia"},{"name":"Department of Medical Pharmacology, Faculty of Medicine Cairo University  Giza 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