{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T07:27:27Z","timestamp":1782458847100,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Hyperactivation of the hypothalamic\u2010pituitary\u2010adrenal (HPA) axis response can result in anxiety and other neuropsychiatric disorders and effective therapeutics are needed to mitigate this maladaptive response. Here we examined the effects of Teneurin C\u2010terminal Associated Peptide (TCAP)\u20101, a peptide known to inhibit corticotropin releasing factor (CRF)\u2010mediated stress, on the physiological expression of stress, and whether the effects of TCAP\u20101 were dependent on the route of administration. We first examined whether subcutaneous administration of TCAP\u20101 influenced tube restraint stress\u2010induced corticosterone (CORT) increases in both male mice and rats. Using a similar model, we further examined the efficacy and time course of intranasal TCAP\u20101. Results showed that subcutaneous TCAP\u20101 administration attenuated the expression of the physiological manifestation of stress in male mice and rats, and that intranasal TCAP\u20101 delivered prophylactically is effective at attenuating stress\u2010induced CORT increases in male rats. These data indicate that TCAP\u20101 delivered though non\u2010invasive routes of administration could have potential as a clinically relevant anxiolytic.<\/jats:p>","DOI":"10.1002\/prp2.70045","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T11:40:16Z","timestamp":1733744416000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Teneurin C\u2010Terminal Associated Peptide (<scp>TCAP<\/scp>)\u20101 Attenuates Restraint Stress\u2010Induced Corticosterone Increases in Male Mice and Rats"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6179-2759","authenticated-orcid":false,"given":"Lauren E.","family":"Mueller","sequence":"first","affiliation":[{"name":"Protagenic Therapeutics Inc.  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roseanne S.","family":"Wexler","sequence":"additional","affiliation":[{"name":"NeoSome Life Science  Lexington Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Lovejoy","sequence":"additional","affiliation":[{"name":"Protagenic Therapeutics Inc.  New York New York USA"},{"name":"Department of Cell and Systems Biology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Stein","sequence":"additional","affiliation":[{"name":"Protagenic Therapeutics Inc.  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Slee","sequence":"additional","affiliation":[{"name":"Protagenic Therapeutics Inc.  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